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Biomedical subjects

P Davis

Publications and source records attributed to P Davis.

At least 451 records · Page 25Linked to original sources
PubMed1973

Immunological studies on the mechanism of gold hypersensitivity reactions.

Immunological studies were performed on 12 patients with rheumatoid arthritis who developed reactions to gold. IgE levels were found to be raised in 10 of 11 patients tested at the time of the gold reaction, returning to normal on stopping therapy. Two of 12 patients with gold reactions had positive in-vitro lymphocyte transformation responses to gold.It is suggested that dermatological side effects in particular are mediated by a type I hypersensitivity response.

Arthritis, Rheumatoid↗
PubMed1973

Criteria for classification of S.L.E.

Of 38 patients with systemic lupus erythematosus (S.L.E.) followed in this clinic during the past two years raised levels of anti-DNA antibodies were found in 36. The recently proposed criteria for the classification of S.L.E. were met in 33 of these 36 patients. Three patients with raised DNA antibody titres and some of the features of S.L.E. did not meet the criteria for a classification of S.L.E.

Adolescent↗
PubMed1973

Tryptophol formation by Zygosaccharomyces priorianus.

Zygosaccharomyces priorianus converted L-tryptophan to tryptophol and to small quantities of indole-3-acetic acid. Neither tryptophol nor indole-3-acetic acid was metabolized when added separately to growing cultures. The possible intermediacy of indole-3-pyruvic acid, indole-3-acetaldehyde, and tryptamine in the degradation of L-tryptophan was tested by feeding these compounds to Z. priorianus and Saccharomyces cerevisiae. Indole-3-pyruvic acid and indole-3-acetaldehyde were converted to tryptophol and indole-3-acetic acid, with the latter accumulating only in small amounts. Tryptamine was converted to its N-acetyl derivative by these organisms. A qualitative study was made on the metabolism of L-phenylalanine, L-tyrosine, and L-5-hydroxytryptophan by these organisms. Like L-tryptophan, these amino acids were metabolized to their respective alcohol and acid derivatives. Of a large number of organisms tested, the yeasts possessed the highest capacity for degrading L-tryptophan to tryptophol.

5-Hydroxytryptophan↗
PubMed1973

Jaundice after multiple halothane anaesthetics administered during the treatment of carcinoma of the uterus.

Halothane is thought to cause hepatitis after multiple exposures in certain susceptible patients. Patients undergoing repeated anaesthetics for insertion of radioactive implants for gynaecological neoplasia appear to be particularly at risk. We are reporting three cases in which hepatitis has followed multiple halothane anaesthetics, and discuss them with reference to our present knowledge of this complication.

Aged↗
PubMed1971

Infections of Scribner and Brescia arteriovenous shunts.

The incidence of infections of Scribner shunts and Brescia fistulae in patients receiving intermittent haemodialysis was compared. In both groups infection was most commonly due to Staphylococcus aureus and was associated especially with carriage of this organism on the skin of the limb where the shunt or fistula was sited. The incidence of local infection was much less with the Brescia fistula but this was accompanied by a relatively higher incidence of septicaemia.

Arteriovenous Shunt, Surgical↗