[Study on triacetyloleandomycin in the prevention of rheumatic fever: its effects on hepatic function].
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Biomedical subjects
Publications and source records attributed to P David.
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Certain congenital malformations affecting the rightsided cavities of the heart and accompanied by a diminished pulmonary blood flow can be improved by an end-to-side anastomosis between the right pulmonary artery and the superior vena cava. Nine out of the 10 patients who underwent the operation survived. The results have been very impressive in six patients with tricuspid atresia who were critically ill. The anoxemic episodes ceased completely and cyanosis has disappeared. Three cases of Ebstein's anomaly have also been improved. This clinical study has given us the opportunity to review the physiological consequences of the anastomosis, its complications and its surgical indications. We believe that this type of shunt is especially indicated in cases of tricuspid atresia, in which only a palliative form of surgery can be performed.
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The pre- and post-operative vectorcardiograms of 55 patients with atrial septal defect (ASD) are discussed. Forty-nine were of ostium secundum type and six of ostium primum type. The criteria used to study the regression of right ventricular hypertrophy were: in the horizontal plane, the ratio of anterior-over-posterior forces, the right-over-left forces and the rotation of the body of the QRS loop; in the frontal plane, the direction of half-area vector. Using these criteria, 46 out of 49 patients with defects of the ostium secundum type had vectorcardiographic evidence of regression of right ventricular hypertrophy. Marked clinical improvement was also demonstrated in all these patients. The three patients in whom improvement was not demonstrated on the vectorcardiogram had persistence of a cardiac defect. Following surgery two children with ostium primum defects showed no change in the frontal plane, whereas in the horizontal plane a normalization of vectorial forces was observed.
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