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Biomedical subjects

P Damiani

Publications and source records attributed to P Damiani.

67 records · Page 4Linked to original sources

Antigen-induced release of histamine from passively sensitized guinea pig lung slices. I. Optimum conditions for in vitro passive sensitization and challenge with antigen.

The effect of several parameters (pH, Ca++ concentration, time, temperature, lung slice size) on in vitro antigen-induced histamine release from passively sensitized guinea pig lung slices was investigated. With respect to pH, Ca++ concentration and time, the optimal conditions for the passive sensitization step (pH 7.8, Ca++ 1.5 mM, 2 h) were distinctly different from those for the antigen challenge step (pH 8.2, Ca++ 10mM, 15 min). Maximum antigen-induced release was obtained with 3 X 0.25 X 0.25 mm lung slices at 37 degrees C using air as gas phase.

Air↗

Fluorometric determination of glycerol in wine--comparison with other known procedures.

The glycerol content of 6 wines was evaluated by using 3 different preliminary treatments and, subsequently, a variety of instrumental and chemical procedures (fluorometric, vapor phase chromatography of trimethylsilyl derivatives, volumetric, and colorimetric). The data showed that all these procedures are applicable; in particular, the fluorometric procedure, which has not been used until now, provides average recoveries of added glycerol ranging from 99.3 to 100.9%, with relative standard deviations ranging from 2.9 to 3.2%. Vapor phase chromatography provides average recoveries of added glycerol ranging from 99.8 to 100.1%, with relative standard deviations ranging from 1.0 to 2.7%. Therefore, the fluorometric procedure appears especially useful for reliable routine analyses, because it is specific for glycerol and provides results that are unaffected by preliminary treatment. Thus it allows analysis of diluted wine, when the sugar content does not exceed 5 g/L; sweet wines must undergo an ion exchange pretreatment.

Glycerol↗

Model of transition between causes of death.

This paper describes an attempt to estimate the probabilities of transition between various major causes of death during the period 1954-1962. The regression coefficients have been estimated from French département death rates for ten main or typical causes of death, assessed by sex for the age group 45-64 years.

Female↗

Blunted erythropoietin response to anemia in patients with Type 1 diabetes.

BACKGROUND: It is known that patients with renal failure have normochromic normocytic anemia due to impaired endogenous erythropoietin (EPO) synthesis. The aim of this work was to determine whether low serum erythropoietin (s-EPO) levels play a role in the pathogenesis of anemia in patients with Type 1 diabetes without overt nephropathy. METHODS: We included in the study 13 patients with Type 1 diabetes whose Hb levels were <11 g/dl. Blood cell count, s-EPO, urinary albumin excretion rate (AER), HbA(1c), glomerular filtration rate, serum iron, serum ferritin, the presence of neuropathy, retinopathy and nephropathy were determined. RESULTS: Ten out of 13 patients with anemia (77%) had a blunted EPO response to anemia. All ten patients with low EPO levels had autonomic neuropathy; five had clinical nephropathy but with serum creatinine<1.6 mg/dl. Three patients were treated with rHuEPO and showed an improvement in their anemia after treatment. CONCLUSION: The majority of patients with Type 1 diabetes who had anemia also had low EPO levels. The pathogenesis of this phenomenon is probably multifactorial. Autonomic neuropathy appears to play a role, but it is not sufficient, per se, to be the only cause. Dysautonomia might enhance the effect of renal damage.

Adult↗

[Infant mortality according to the duration of gestation].

By studying the statistics given in the civil register, mortality tables of infants dying under the age of one year have been compared with the duration of the pregnancy (7 months, 8 months, 9 months). These tables show the probability of death day by day in the first week, week by week in the first month and monthly in the first year. They show the influence of the length of gestation on mortality. Furthermore the probability of the death of a foetus of more than 6 months gestation has been calculated.

Female↗

[Riboflavin content of commercial samples of alimentary pastes (author's transl)].

By fluorometric investigation on 42 commercial samples of alimentary pastes, it was established that unlawful custom of colouring these food products with riboflavin is no more performed; in fact, the riboflavin content of the sample examined by use was rather uniform and of the same order of that naturally occurring in these products.

Edible Grain↗