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Biomedical subjects

P Da Re

Publications and source records attributed to P Da Re.

At least 37 records · Page 2Linked to original sources
PubMed1982

Azidofibrate. Synthesis and evaluation of its effects on fat cell lipolysis in vitro.

Synthesis and biological properties of a new ethyl alpha-(p-chlorophenoxy)-isobutyrate (clofibrate) analogue are described. Replacement of the chlorine atom of the parent drug by an azido group has been attempted in order to avoid the proliferative action on liver peroxysomes. The new compound showed a good degree of inhibition of rat fat cell lipolysis and its action, qualitatively different from that of clofibrate, bears some analogy with that of nicotinic acid.

Animals↗
PubMed1982

Xanthone analogues of clofibrate / Synthesis and biological evaluation as antagonists of lipolysis in vitro.

By appropriate superimposing of fenofibrate and fenofibric acid molecules, two xanthone derivatives (closed models) may be obtained. These compounds as well as their four chlorine-free isomers were prepared and tested on adrenaline- and theophylline-induced lipolysis in rat fat cells in comparison with ethyl 2-(4-chlorophenoxy)-2-methylpropionate (clofibrate). Some of these new derivatives besides being good inhibitors of adrenaline effect, as clofibrate is, were also very active in reducing theophylline-induced lipolysis. Very promising for further studies is the chlorine-free 3-isomer (3e). The possible difference in the action mechanism of these compounds as compared with clofibrate and the structure-activity relationships are briefly discussed.

Adipose Tissue↗