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Biomedical subjects

P D Lester

Publications and source records attributed to P D Lester.

At least 37 records · Page 2Linked to original sources

Congenital macular colobomas and short-limb skeletal dysplasia.

We report a previously undescribed association of severe short-limbed dwarfism and macular colobomas with histological changes of cartilage resembling to some extent those of diastrophic dysplasia. Chance occurrence of two rare disorders due to different causes is considered unlikely and the patient is presumed to have a syndrome of, as yet, unknown cause.

Bone and Bones↗

CT demonstration of cortical nephrocalcinosis in congenital oxalosis.

The clinical, pathologic and roentgenographic features of a case of congenital oxalosis are discussed and contrasted to the more common forms of primary oxalosis. The ease of demonstration of the cortical deposition of calcium oxalate crystals on the CT scanner is reported.

Amino Acid Metabolism, Inborn Errors↗

Fibrous dysplasia and precocious puberty (McCune-Albright syndrome).

A patient with fibrous dysplasia and precocious puberty, with pneumogynographic demonstration of an enlarged uterus and ovaries at age 16 months has been followed up to age 14 years. The pneumogynographic findings and the chemistries implicate central nervous system stimulation as the cause of the precocious puberty.

Air↗

Asymmetric ovarian enlargement in idiopathic precocious puberty.

A patient with precocious puberty is presented in whom the pneumogynogram showed only one enlarged ovary. Because tumor could not be excluded, the patient had exploratory operation six weeks later. Both ovaries and the uterus were enlarged, compatible with the central stimulation seen in idiopathic precocious puberty. Care should be used in interpreting pneumogynograms as evidence of possible ovarian tumor in young girls with precocious puberty who have only modest unilateral ovarian enlargement.

Child↗

Gastric emphysema in infants with hypertrophic pyloric stenosis.

Gastric emphysema in unusual in infants and children. Air in the wall of the stomach can rarely occur in children with gastric outlet obstruction due to hypertrophic pyloric stenosis. The clinical features and radiographic appearance of this association are described in three infants, and the value of the lateral radiograph is illustrated. The differential diagnostic considerations, importance of correct radiologic diagnosis and results of proper therapy are discussed.

Emphysema↗

Pneumopelvigraphy in childhood.

Pelvic pneumography was performed in 150 children, including those with precocious puberty, suspected pelvic masses, abdominal pain, virilization, ambiguous genitalia, gonadal dysgenesis, Stein-Leventhal syndrome, amenorrhea, and contralateral inguinal hernia detection. Pneumography proved safe, accurate, and easy to perform. However, advances in sonography have limited the use of pneumography primarily to the investigation of infant intersex problems and confirmation of idiopathic precocious puberty in the infant or very young girl.

Adolescent↗

Post-traumatic pneumatocele in the inferior pulmonary ligament.

Pneumatocele localized to the inferior pulmonary ligament is an uncommon sequel of blunt chest trauma. Three such cases are reported and the characteristic location and appearance of the pneumatocele, as well as its benign course, are discussed. A similar radiographic appearance has been produced in cadavers by injecting air into the inferior pulmonary ligament.

Adolescent↗

The abdominal angiographic spectrum of tuberous sclerosis.

Tuberous sclerosis can present with a variety of clinical, roentgenographic and pathological manifestations. Although we are not advocating abdominal angiography in every patient with tuberous sclerosis, the clinical diagnosis may be difficult in certain cases, particularly in the young patient, and abdominal visceral angiography may lead to the correct diagnosis. In two of our patients, infants ten months of age, the diagnosis of tuberous sclerosis was not made until abdominal angiography had been performed. The most common changes are seen in the kidney where angiographic demonstration of hamartomas, arterial aneurysms, and multiple small cysts in the renal parenchyma are noted. Renal microcysts have not been previously described angiographically although they have been noted in pathological specimens and represent an important feature of the disorder spectrum. In addition, vascular hamartomatous lesions may be demonstrated angiographically in other abdominal organs such as the adrenal gland and liver.

Abdomen↗

Osteoid osteoma.

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Bone Neoplasms↗