Search PubMed⌕ Search

Biomedical subjects

P Cugini

Publications and source records attributed to P Cugini.

At least 109 records · Page 6Linked to original sources
PubMed1990

Common migraine as a weekly and seasonal headache.

The aim of this study was to demonstrate that a possible recurrence may pertain to migraine attacks (MAs). The study was carried out by checking the personal diaries of 30 migraine sufferers ("migraineurs") who carefully annotated the date of their MA over twelve consecutive months. The group was composed of 15 males and 15 females, ranging in age from 17 to 37 years. The individual MAs were summarized in order to obtain the time-qualified frequency per each time period of recurrence. The periodicity in time data series was analysed by means of the Single Cosinor method. The rhythmometric analysis was found to be highly statistically significant; the circaseptan (P = 0.007) and circadian (P = 0.004) recurrence of MA showing critical incidence on Sunday and in January, respectively. No circatrigintan periodicity was validated in relation to the solar and lunar months or menstrual cycle. These findings suggest to us a possible linkage of MA to environmental factors which entrain the routine of our lives. Because of the circaseptan and circannual repetitivities, common migraine syndrome was defined as a "weekly and seasonal headache".

Adolescent↗
PubMed1990

[Overall biostatistical approach to the 24-h behavior of arterial blood pressure in chronic uremic normotensive patients].

The present study discusses the 24-h patterns of blood pressure in chronic uremic patients classified as normotensives by means of casual sphygmomanometric measurements. Data obtained enabled us to affirm that the blood pressure of normotensive chronic uremic patients is not normal due to a wider distribution, the occurrence of supraphysiologic values during day-night time and the absence of a circadian rhythm. The lack of a nocturnal decrease in blood pressure causes a hyperbaric impact on the arterial wall for "normotensive" chronic uremic patients.

Adolescent↗
PubMed1989

Usefulness of twenty-four-hour blood pressure patterns and response to short-term sodium restriction in normotensive subjects in detecting a predisposition to systemic arterial hypertension.

Twenty clinically healthy subjects were studied to identify normotensive adults with a predisposition to arterial hypertension by monitoring blood pressure (BP) and restricting dietary sodium intake. Short-term restriction in sodium intake resulted in a decrease of the mean level for the circadian rhythm of BP. The phenomenon is visible in subjects without familial hypertension but not in individuals with a positive history for high BP. The response of the 24-hour BP patterns to abrupt sodium deprivation seems to be an indicator for discovering normotensive subjects at risk of developing arterial hypertension.

Adult↗
PubMed1989

The circadian rhythm of serum angiotensin-converting enzyme is disrupted in ascitic liver cirrhosis.

An increase in morning fasting levels of plasma (P) renin activity (RA), aldosterone (A) and serum (S) angiotensin-converting enzyme (ACE) activity has been demonstrated in ascitic cirrhotic patients (ACP). Since both PRA and PA change biorhythmically in their time structure, the relationship of SACE activity with the components of the renin-angiotensin-aldosterone system (RAAS) was investigated in clinically healthy subjects (CHS) and ACP. Time-qualified data were chronobiologically analysed by means of the cosinor procedure to resolve and quantify the circadian rhythm (CR). The 24-hour mean levels of PRA, PA and SACE activity were found to be elevated in ACP as compared to CHS. The temporal variability of these analytes was found to be of periodic type along the 24-hour span in CHS, but not in ACP. The well-organized cyclicity in CHS is of relevant interest. PRA and PA cycles were found to phase in a clear antiparallelism with the SACE activity CR. The phase opposition may be, speculatively, related to the physiologic nature of ACE, whose activity is devoted to generate angiotensin II. The disappearance of SACE activity CR in ACP is in accordance with the abolition of PRA and PA cyclicity and suggests a role of liver in regulating the periodic time function of the RAAS and related components.

Adult↗
PubMed1989

Chronobiological evidence for an uncoupling of the Na,K-ATPase to aldosterone in normal renin hypertension.

The Na,K-ATPase activity of erythrocyte membranes is markedly increased in normal-renin essential hypertensives. A temporal shift of the chronobiology of the erythrocyte-membrane-bound Na,K-ATPase in these patients is described. The disorder causes a loss of synchronism between the circadian rhythms of aldosterone and Na,K-ATPase. Such uncoupling phenomenon may explain the inversion of the day/night sodium excretion ratio and other disturbances of sodium metabolism found in essential hypertensives.

Adolescent↗
PubMed1989

Preventive distinction of patients with primary or secondary hypertension by discriminant analysis of chronobiologic parameters estimated on 24-hour blood pressure patterns.

This investigation deals with a statistical probatory that patients with primary (PH) or secondary (SH) hypertension may be correctly diagnosed by a discriminant analysis of the chronobiologic characteristics computed on the 24-hour blood pressure (BP) patterns. The methodology concerning non-invasive 24-h BP monitoring, chronobiologic analysis and the discrimination process is detailed. Substantial dissimilarities were found in the statistical distribution for systolic and diastolic BP rhythmometric parameters (mesor, amplitude and acrophase) by a retrospective assessment of two groups, consisting of 54 patients with PH and 16 patients with SH. The group-related distribution for rhythmometric parameters was found to be significantly different to generate a statistically significant intergroup discriminatory boundary. The discriminant analysis correctly diagnosed patients with PH and SH in a percentage of about 91% and 63%, respectively. The high incidence of success is convincing that the combination of 24-h BP monitoring/chronobiologic analysis/discrimination process cna be a practical tool for confidently selecting patients with a presumable PH or SH.

Adolescent↗
PubMed1989

"GIANT" macronodular adrenal hyperplasia causing Cushing's syndrome: case report and review of the literature on a clinical distinction of adrenocortical nodular pathology associated with hypercortisolism.

Cushing's syndrome (CS) may be sustained by a nodular adrenocortical pathology (NAP) in addition to hyperplastic or neoplastic lesions of adrenal glands. NAP, in turn, may be represented by macronodular (MACRO) or micronodular (MICRO) manifestations. There is debate as to whether the MACRO-NAP and MICRO-NAP represent an expression of the same disorder or relate to distinguishable anatomo-clinical entities. A case of CS sustained by a "giant" MACRO-NAP forced use to review the literature and to analyze the morpho-clinical findings from a statistical viewpoint. Testing procedures were able to significantly dissect some clinical, pathological and hormonal characteristics. The statistical probation clearly indicated that MACRO-NAP and MICRO-NAP causing CS are nosologic entities that can be clinically differentiated via their phenotypic symptomatology.

Adrenal Cortex↗
PubMed1989

[24-hour behavior of T-lymphocyte subpopulations in patients with stable heart transplants receiving cyclosporin therapy].

In 10 heart transplanted subjects (HTS) undergoing conventional immunosuppressive cyclosporine therapy, in comparison with 10 normal subjects, the 24 hour patterns of T lymphocyte subpopulations, namely, OKT3 (total T lymphocytes), OKT4 (helper lymphocytes) and OKT8 (cytotoxic or suppressor) in relation to the circadian rhythms for plasma cortisol (marker rhythm) and to circulating levels of cyclosporine were studied. From the collected data, it can be deduced that the OKT3, OKT4, OKT8 subpopulations and the plasma cortisol level show 24-hour non-periodic variations. The lymphocyte subpopulations show a negative correlation with circulating levels of cyclosporine. The negative correlation is "selective" and "delayed" in that it is detectable at particular and non-coinciding hours. Plasma cortisol is also negatively correlated to plasma cyclosporine. Assessing the meaning of the lack of a circadian rhythm of the lymphocyte subpopulation in HTS undergoing conventional cyclosporine therapy, and taking into account the pharmacological time-stage dependency, we can emphasize the idea that the optimization of anti-rejection therapy with cyclosporine may and should be performed as a time-modulated treatment.

Adult↗