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Biomedical subjects

P Cugini

Publications and source records attributed to P Cugini.

At least 181 records · Page 10Linked to original sources
PubMed1980

Renal-portal shunt to restore normal reninism and blood pressure in experimental renovascular hypertension in dogs.

The role of the liver in the metabolism of renin was evaluated in dogs with high plasma renin and hypertension due to experimental bilateral renal artery stenosis. Ten adult dogs were studied in three consecutive phases: (1) basal conditions, (2) with bilateral ischemic kidneys, and (3) after derivation of renal vein blood into the portal system. Secretion, total clearance, hepatic clearance, and hapatic extraction of renin were estimated in each phase by measuring plasma renin activity (PRA) in blood collected simultaneously from arteries, inferior vena cava, vena porta, hepatic and renal veins, and by determining renal and hepatic blood flow. Blood pressure was measured by intra-arterial catheterization. The results demonstrated an increase in the hepatic metabolism of renin when the hyper-reninemic patterns of renal blood directly perfused the liver. Under these conditions, hepatic and circulating renin fell to basal values and blood pressure returned to normal.

Animals↗
PubMed1980

Beta-adrenergic regulation of circadian rhythmicity of the renin-angiotensin-aldosterone system in five subtypes of essential hypertension.

The possible implication of the beta-sympathoadrenergic system in regulating the rhythmicity of the renin-angiotensin-aldosterone system (RAAS) was studied in ten normotensive volunteers and in thirty-nine essential hypertensive patients. The study was carried out by simultaneous radioimmunological measurements of diurnal levels of plasma renin and aldosterone before and during acute oral medication of beta-adrenoceptors with propranolol. Acute beta-blockade was seen to blunt the circadian periodicity of plasma renin and aldosterone in normotensives and in hypertensives with normal or high renin patterns. Conversely propranolol was seen to be ineffective in low-renin patients. The disappearance of the circadian rhythms under beta-adrenoceptor blockade tends to suggest the existence of a beta-adrenergic control of RAAS cyclicity in normal condition, as well as in normal or high renin essential hypertension. The inefficacy of propranolol in hyporeninemic hypertensives is consistent with the hypothesis that low-renin essemtoa; juertemsopm os a state in which the sympatho beta-adrenergic mechanism controlling the function of RAAS has no biologic time structure.

Adolescent↗
PubMed1979

[Temporal aspects of the function of the renin-angiotensin-aldosterone system. Contribution to the methodological standardization of explorative test (author's transl)].

The purpose of this study is to throw further light on the problem of the methodological standardization in the study of the renin-angiotensin-aldosterone system (RAAS). Thus, in 10 normal volunteers and 33 patients with moderate, recent and uncomplicated essential hypertension, divided into the subtypes with normal, high and low renin, it has been performed a timing analysis of the behaviour of plasma renin (PRA) and aldosterone (PA). PRA and PA were measured by radioimmunological methods in blood samples simultaneously collected in steady state conditions (study of circadian rhythmicity) and during the course of manipulative tests (orthostatism, dietary sodium restriction, orthostatism associated with sodium restriction, furosemide administration). The study revealed that each category of the present series of healthy and hypertensive individuals has an own temporal organization in the entire function of RAAS. This finding allowed to standardize the RIA reference indices as chronocorrelated intervals of normality and to establish the optimal criteria for the assessment of biochemical data and methodological study of hypertensive patients.

Adolescent↗