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Biomedical subjects

P Cozette

Publications and source records attributed to P Cozette.

At least 19 recordsLinked to original sources
PubMed2005

[Application of McAbs against rabies nucleocapsid in diagnosis of rabies street virus].

OBJECTIVE: McAbs against rabies nucleocapsid were used to detect rabies street viruses in animal brain specimens with indirect immunofluorescent assay to evaluate the sensitivity and specificity of this assay. METHODS: 62 specimen from rabid animal brains including genotype 1 to 7 and 271 specimens from different normal animal brains collected in Pasteur Institute in 2003 were tested and compared, using indirect immunofluorescent assay. All these specimens were identified and compared using rapid rabies enzyme immunodiagnosis, fluorescent antibody test and rabies virus isolation assay in neuroblastoma cell culture which were all provided by Pasteur Institute. RESULTS: Both sensitivity and the specificity of the indirect immunofluorescent assay were 100%. CONCLUSION: The results showed a positive of rabies virus detection with these methods.

Animals↗
PubMed1994

[Renal involvement in POEMS syndrome].

We described a patient with a POEMS syndrome (Polyneuropathy, Organomegaly, Endocrinopathy, Monoclonal grammapathy and Skin changes) who was found to have renal involvement with peculiar renal pathological findings. Hitherto, 17 other cases, most of them from Japan, of POEMS syndrome with renal involvement, have been published. Clinical features are variable: acute renal failure with anasarca or moderate chronic renal insufficiency with mild proteinuria. This latter presentation often passes unnoticed. There is no severe HTA, no microangiopathic hemolytic anemia. Renal biopsy shows prominent glomerular changes which are unusual and distinct from membranoproliferative glomerulonephritis (MPGN) and from glomerular thrombotic microangiopathy (TMA). Mesangial proliferation and thickening of the capillary wall with double contour evoke by light microscopy a MPGN. By immunofluorescent microscopy, no immunoglobulins or complement deposits are found. The finding of mesangiolytic lesions has led to the term of "mesangiolytic glomerulonephritis". The presence, on electron microscopy, of lucent subendothelial space could evoke TMA. But there is neither thrombi, nor arteriolar changes. We are inclined to presume that microangiopathic lesions are due to chronic injury of glomerular endothelial cells, exacerbated at outbreaks of the disease. An increased production of IL-6 could support the efficacity of corticosteroid therapy, particularly in acute clinical situations.

Adult↗
PubMed1986

[Technics and results of autografts in surgery of pterygium. Study based on 34 grafts].

The first procedure consists of corneal autograft sampled at noon or six o'clock on the pterygium's excision bed, combined to a conjunctival flaps translation. The second technique consists of a monoblock corneoconjunctival graft with a limbic hinge. The operative difficulties, post-surgical complications and results are discussed. The results seem very promising: one recurring case out of 34 grafts performed. The recurring risk, more acute in tropical environment where it is frequently impossible to obtain corneal homografts is greatly reduced by autografts.

Adult↗
PubMed1979

[Rheological effects of normovolemic hemodilution].

Blood viscosity depends essentially on two factors: shearing rate, since the blood is not a Newtonian liquid and the hematocrit, any fall in which tends to cause the blood to become closer in its behaviour to a Newtonian liquid. Furthermore, these two factors are interdependent. When the hematocrit falls, blood viscosity decreases in greater proportions at lower shearing rates than at high shearing rates. Whilst in vitro, in hemodilution, results vary in relation to the type of replacement solution, in vivo this factor would appear to be of little importance by virtue of the adapted variations in the deformability of the red cells. However, hemodilution results in the greatest relative decreases in blood viscosity at the highest hematocrits. Below a hematocrit of approximately 30 p. cent, the gain in terms of viscosity is very low. This figure would appear to be the ideal hematocrit level from a rheological standpoint. An additional rheological advantage is provided by hemodilution the instability of red cell rouleaux, which are in fact created more readily in areas where shearing rate is low. All of these rheological changes explain the hemodynamic consequences.

Blood Viscosity↗
PubMed1977

[Stress ulcer].

Explore the source record for details and available documents.

Adolescent↗
PubMed1977

[Pulmonary mechanics and alveolar exchanges in the elderly with apparently healthy lungs. Preliminary study].

A group of ten elderly subjects who were apparently normal from the cardiac and pulmonary points of view, were selected on criteria of history, clinical findings, radiological and E.C.G. findings, with a view to a study of respiratory function based on two aspects: alveolar exchanges were assessed by measurement of the ductance of carbon monoxide and the elastic properties of the lung together with bronchial permeability. Although alveolar exchanges are little modified, one may note some pulmonary distension, especially in the smokers, together with a reduction in elasticity. The changes in bronchial permeability which affect the peripheral and central airways, are mainly found in smokers. One may determine the respective roles of extrinsic and intrinsic bronchial obstruction in these abnormalities. One may thus consider that, from the pulmonary point of view, the elderly patient faced with a surgical operation should be considered a high risk for respiratory decompensation, especially if he is, or has been, a smoker.

Aged↗
PubMed1977

[Fat overload during intake of lipids].

A review of the recent literature indicates that fat overload during the infusion of lipid emulsions remains rare, at least clinically. Nevertheless, two pictures may be seen, the physiopathology of which is discussed:--overload syndrome, with an association essentially of general and digestive signs, related to the accumulation of lipids in a certain number of parenchymatous tissues;--fat embolism. Problem may be seen at any time after administration of the solution is begun. Youth seems to predominate amongst the favourising factors. Prevention is possible if rules of caution concerning dose and the rate of administration are respected, combined with biological surveillance involving at laboratory studies at least once a week.

Acute Disease↗
PubMed1976

[Prevention of stress ulcer by vitamin A. Experimental study in rats].

71 male rats (Whitstar strain) are submitted to restraint. 37 of them were receiving twice an injection of 10 000 I.U. of vitamin A in order to protect them against the occurence of stress ulcer. Untreated animals are used as controls. Incidence of obtained ulcer is compared with the variation of vitamin A serum concentration, classicaly decreased in stress. Analysis of individual results shows that, if parenteral administration was followed either by restitution of the initial serum concentration, or by its increase, the treatment was efficient in 64 p. 100 of the cases.

Animals↗
PubMed1975

[A case of leiomyoma of the iris].

A case of leiomyoma of the iris confirned to the nasal quadrant in a 64 year old man is presented. The clinical and histopathological characteristics of this observation confirms the classical data about this rare tumor : clinical silence, discovery through a complication, difficult diagnosis, therapeutical value of the surgical biopsy and good prognosis.

Eye Neoplasms↗
PubMedDate not supplied

[Electro-clinical features of short-term anaesthesia (author's transl)].

Short-term anaesthesia is defined in terms of duration (allowing brief but what might be painful surgery), rapid recovery, metabolism and mode of administration. After a brief review of barbiturate narcoses, the authors study the electro-clinical features of anaesthesia under Althesin, Epontol and ketamine. For the first two, although there are some clinical differences, the E.E.G. effects are fairly similar with rapid onset of burst suppression. Recovery is rapid and its study (clinically, with psychomotor tests and E.E.G.) indicates that these drugs can safely be used with out-patients. Ketamine causes very specific alterations, both clinical (dissociative anaesthesia) and E.E.G. (diffuse and continuous theta). This drug is used particularly in painful operations; its use with out-patients would seem awkward.

Adolescent↗
PubMedDate not supplied

[Artificial lenses at the Institute of Tropical Ophthalmology of Africa].

The authors present a report on the first set of twenty-three intra-ocular lenses fitting on subjects from Mali, performed at the "Tropical African Ophthalmology Institute" (I.O.T.A.) from december 1983 up to december 1984. This report deals mainly about the implants of the inner aqueous chamber of the eye after the intracapsular extraction. The mechanical complications and inflammatory corneal and retinal consequences which occurred after the surgical operation are being tested. None of these complications has questioned the visual and functional prognosis. So, the results seem quite good. Nevertheless, the mass-surgery concerning the cataract with the fixing of an intra-ocular lens will be able to be considered when the cost of the implants is materially reduced.

Adult↗