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Biomedical subjects

P Courtright

Publications and source records attributed to P Courtright.

At least 55 records · Page 3Linked to original sources
PubMed1997

Excess mortality associated with blindness in leprosy patients in Korea.

Vision loss and blindness are potential complications of leprosy. There is little data available to indicate the impact of eye complications on life expectancy and quality of life. We sought to determine the relative risk of death in blind leprosy patients compared to nonblind leprosy patients. A population-based ocular survey of 510 mycobacteriologically negative leprosy patients in rural South Korea, conducted in 1988, formed the study population. After a 7-year period patients were traced to determine their status (alive, dead, lost to follow up). Blind patients showed a 4.8-fold risk of death, even after adjusting for other factors, compared to nonblind patients. Young blind leprosy patients had the highest relative risk of death. Excess mortality was not associated with any specific cause of blindness, ocular pathology, or type of disease. Findings from our study suggest that all leprosy patients with ocular disabilities (including those released from antileprosy treatment) should be targeted to receive eye care to prevent vision loss. Particular emphasis should be placed on young patients.

Aged↗
PubMed1997

Correlation between the visual field indices and Heidelberg retina tomograph parameters.

PURPOSE: We wished to determine whether a relationship exists between Heidelberg retina tomograph (HRT) parameters and the visual field indices. METHODS: One eye was randomly chosen from 59 normal patients [normal visual field and normal optic nerve head (ONH) and intraocular pressure (IOP) < 21 mm Hg], 64 ocular hypertensive patients (normal visual field and normal OHN and IOP > 22 mm Hg), 124 high-tension glaucoma patients (abnormal visual field and/or abnormal optic nerve and IOP > 22 mm Hg) and 47 low-tension glaucoma patients (abnormal visual field and or optic disc and IOP < 21 mm Hg). All the patients were examined with Humphrey Perimeter, program 30-2, and HRT. Findings were assessed by analysis of variance, Pearson's correlation coefficient, and multiple linear regression. RESULTS: Among all subjects, we noted a statistically significant correlation (Pearson's r, p < 0.001) between cup area, cup/disc area ratio, rim area, rim volume, cup shape measure, and retinal nerve fiber layer cross-section area with mean deviation and corrected pattern SD. Multiple linear regression analysis demonstrated that rim area was the most important predictor of mean deviation and corrected pattern SD. CONCLUSIONS: The presence of significant correlations between some HRT parameters, such as rim area and cup shape measure and visual field indices, suggests that these HRT parameters could be good indicators of the degree of glaucomatous ONH damage.

Glaucoma, Open-Angle↗
PubMed1996

Changing patterns of corneal disease and associated vision loss at a rural African hospital following a training programme for traditional healers.

AIMS/BACKGROUND: Use of African traditional eye medicines (TEM) is associated with the presence of corneal disease, delay in presentation, and vision loss. An interactive training programme was conducted with traditional healers in Chikwawa District, Malawi and changes in the pattern of corneal disease assessed in patients presenting to the district hospital after the training. METHODS: All patients presenting to the district hospital with corneal disease for a 15 month period before intervention and a 12 month period after intervention were enrolled in the study. Interviews and examinations were carried out by the same person using a standardised, pretested form. RESULTS: Among the 175 pre-intervention and 97 post-intervention patients, delay in presentation improved only slightly. Blindness among patients reporting the use of TEM decreased from 44% to 21%; bilateral corneal disease in patients using TEM decreased from 31% to 10%. Multivariate analysis demonstrates that poor vision in corneal disease patients continues to be associated with TEM use and distance from the district hospital. CONCLUSION: As there were no other relevant eye health programmes in the district it is believed that this collaborative eye care programme with the traditional healers was likely to have been responsible for many of the changes in the pattern of corneal disease in the district. Although the changing patterns are encouraging and are likely to improve with additional collaboration, distance to a district hospital will continue to be a barrier to timely use of Western eye care services.

Blindness↗
PubMed1995

Eye care knowledge and practices among Malawian traditional healers and the development of collaborative blindness prevention programmes.

Many African traditional healers provide treatment for eye diseases, yet there is little published information about eye care knowledge and practices among these healers; the information is necessary for the development of collaborative eye care activities with healers. Focus group discussions, in-depth interviews, and a representative sample survey of 107 randomly selected traditional healers in Chikwawa District, Malawi were conducted regarding eye care knowledge and practices. In the survey 68% of healers treated at least one of six common eye conditions. The most common eye condition treated by healers was cataract, followed by conjunctivitis/inflammatory trachoma. The size of the healer's practice, literacy, and great distance to a health facility were positively associated with the provision of eye care. Traditional healers have considerably more eye care interactions with the rural population than existing biomedical health personnel in Chikwawa District. Interviews revealed that most healers were aware of the availability of treatment for common eye conditions at biomedical health facilities and were interested in collaborating with existing biomedical eye care providers. We subsequently developed a collaborative eye care programme with healers in the district and report on early findings. Collaboration with healers in eye care programmes is advocated and recommendations are provided.

Adult↗
PubMed1995

Corneal decompensation after cataract surgery. An outbreak investigation in Asia.

PURPOSE: During 5 days in January 1994, two visiting expatriate ophthalmologists performed extracapsular cataract surgery on 111 patients at a nonprofit hospital in Asia. The authors investigated the development of postoperative corneal edema. METHODS: An epidemiologic and clinical investigation was undertaken by a review of clinical charts, interview of personnel involved, an examination and interview of patients who underwent surgery, and a laboratory simulation of the disinfection procedure used. RESULTS: Follow-up was available on 58% of the patients. The attack rate was at least 37% and likely to be approximately 64%. The attack rate was highest the first 2 days of surgery. Multivariate analysis showed that the day of surgery was the only characteristic significantly associated with the presence of corneal edema. A simulation of the disinfection technique used (soaked in 2% glutaraldehyde and rinsing) showed that significant levels of glutaraldehyde remain in instruments with small lumens after the rinse. CONCLUSION: The epidemiologic data and simulation information are compatible; the lack of adequate rinsing of small lumen instruments soaked in glutaraldehyde is the most probable cause of this incident. Recommendations for surgeons on surgical expeditions are proposed.

Asia↗
PubMed1995

The distribution of kwashiorkor in the southern region of Malawi.

Using existing nutritional survey data collected over an 11-month period during the recent drought, we sought to determine the distribution of kwashiorkor in the ten districts of the Southern Region of Malawi. Sampling and survey methods were identical and considerable efforts were made to ensure comparability. In 23 surveys, 25,824 children were weighed and measured and oedema was recorded. The district-adjusted prevalence of kwashiorkor was 18/1000. The northernmost districts of the Southern Region had rates five to ten times higher than the southernmost districts. Prevalence peaked at 18-23 months and was similar in boys and girls. Dysentery was associated with the presence of kwashiorkor while diarrhoea was not. The distinctive pattern of kwashiorkor in the region suggests that there are characteristics specific to the northern districts that place children in these areas at greater risk of kwashiorkor.

Child, Preschool↗
PubMed1995

Peripheral corneal ulcers associated with use of African traditional eye medicines.

The most common cause of monocular blindness in Africa is corneal opacification. Traditional eye medicines (TEM) are widely used in Africa and their use has been associated with corneal ulceration, however, no controlled studies of the effects of TEM on the cornea have been published. We conducted a case-control study of 39 patients with corneal ulcers matched to controls with severe conjunctivitis. Microbiological investigations were conducted on 20 cases. There was a significant association between corneal ulceration and TEM use and, in particular, peripheral corneal ulcerations were significantly associated with TEM use.

Adolescent↗
PubMed1995

Vitamin A capsule supplementation in Malawi villages: missed opportunities and possible interventions.

A population-based survey was used to assess childhood and maternal vitamin A capsule coverage in Malawi and to investigate missed opportunities for capsule distribution. Overall, 9.3% of children had received vitamin A supplementation in the previous 6 months. Missed opportunities for receiving vitamin A were high in younger children. Fifty-five percent of mothers were covered in 8 villages served by volunteers and 23% in the 58 villages without volunteers. Existing strategies need to be redesigned and new strategies defined. For instance, mothers could receive supplementation during infant BCG vaccination, and children could receive initial supplementation during measles vaccination. Village health volunteers could be used to target children over 2 years of age.

Child Nutritional Physiological Phenomena↗
PubMed1995

A population-based survey of the prevalence of refractive error in Malawi.

Refractive errors, particularly myopia, are a common problem in industrialized countries, but the impression exists that myopia may be relatively uncommon in non-industrialized societies. We conducted a population-based survey of refractive error in two groups of Malawians: a group of rural agricultural workers (n = 510) and a group of students at an urban teachers' college (n = 534). The overall prevalence of myopia was low; 2.5% (95% confidence interval 1.3%, 3.7%) of participants had an error of -0.5 D or greater. The mean refractive error (right eye) in the urban student group was +0.52 D compared to +0.62 D among the rural agricultural workers and the excess myopia was accounted for by significant myopia (> or = -0.75 D) in a few individuals, rather than an overall shift towards myopia within the urban student group. Among the rural agricultural workers, literacy predicted refractive error (right eye), with a mean of +0.59 D in the rural literate compared to +0.67 D in the rural illiterate. These findings support the notion that myopia is uncommon in non-industrialized societies and that it is associated with increased literacy but we have not identified specific risk factors within this group to predict the occurrence of significant myopia. In settings such as Malawi, refractive services should be targeted to urban centers, where more educated populations are likely to be found.

Adolescent↗
PubMed1995

Lagophthalmos in a multibacillary population under multidrug therapy in the People's Republic of China.

Lagophthalmos may be the most common potentially blinding ocular condition in leprosy. The magnitude of the problem among multibacillary patients has not been determined. We sought to ascertain the magnitude of lagophthalmos in a multibacillary leprosy patient population under multidrug therapy (MDT) (both newly diagnosed and with a prior history of dapsone monotherapy) in China and assess factors associated with its presence. In a survey of 640 multibacillary patients 3.8% of the newly diagnosed patients and 10.2% of the patients with prior dapsone monotherapy had lagophthalmos. Corneal disease and vision loss were common in both groups. Poor compliance with MDT, duration between onset and diagnosis, and duration on dapsone monotherapy were associated with the presence of lagophthalmos. Our findings suggest that there may be a threshold at which MDT must be maintained to prevent lagophthalmos. Early leprosy diagnosis and treatment would also lessen the incidence of lagophthalmos in these patients. The high proportion of lagophthalmos patients with corneal disease suggests that there has been inadequate eye care for these patients.

Adult↗
PubMed1995

Current concepts in the surgical management of lagophthalmos in leprosy.

Existing data suggest that, at a minimum, 2% of paucibacillary patients and 5% of multibacillary patients have lagophthalmos; at least 290,000 people worldwide have leprosy-related lagophthalmos. Surgical intervention is the only method for correcting lagophthalmos; effectiveness of the different procedures commonly used has not been measured. Results from a survey of eye care providers revealed that surgeons in Asia used a wide range of different techniques for the correction of lagophthalmos while almost all of the surgeons in Africa used tarsorrhaphy. There is a need to evaluate surgical outcome of these techniques and to develop guidelines to assist in increasing the number of surgeries for lagophthalmos in leprosy patients.

Corneal Diseases↗
PubMed1995

Barriers to acceptance of cataract surgery among patients presenting to district hospitals in rural Malawi.

The objective of this research was to assess the barriers to cataract surgical acceptance by blind rural Malawians recognized and referred for surgical correction at district hospitals. Cataract blind recognized and referred for surgery by the ophthalmic assistants in Chikwawa and Nsanje Districts were interviewed 9-12 months after enrolment to determine if they had undergone cataract surgery and to assess factors associated with surgical acceptance. There were significant gender-specific baseline differences between men and women presenting to the ophthalmic assistants. Patients living near the district hospital were also most likely to present to the ophthalmic assistant. Men with lower socioeconomic status were more likely to accept surgery than men with higher socioeconomic status. Men and women who either talked to someone about cataract surgery or knew another aphakic patients were more likely to accept surgery. The best approaches to improving cataract acceptance given existing resources might be to encourage patients undergoing cataract surgery to educate and motivate others to accept surgery and to train existing village level health staff in cataract recognition and referral. Economic barriers and lack of family support are likely to continue to impede improved cataract surgical acceptance, especially among women.

Cataract Extraction↗
PubMed1994

Multidrug therapy and eye disease in leprosy: a cross-sectional study in the People's Republic of China.

BACKGROUND: Factors associated with leprosy-related eye disease in a multidrug therapy (MDT) treated population in China were assessed to determine if status prior to inclusion in the MDT programme (newly diagnosed leprosy patient or leprosy patient on prior dapsone monotherapy) contributed to the prevalence of ocular pathology. METHODS: Trained leprosy paramedical workers in Sichuan Province examined 974 leprosy patients in a standardized fashion. Univariate analyses and multiple logistic regression were used to assess the contribution of demographic and clinical parameters to leprosy-related eye disease. RESULTS: In both groups (prior dapsone and new MDT) leprosy-related eye disease was associated with a longer distance to leprosy health worker or health centre. Among patients with a history of prior dapsone monotherapy, age and duration on dapsone monotherapy were also associated with leprosy-related ocular morbidity. Among newly diagnosed leprosy patients the prevalence of ocular morbidity remained between 8% and 11% regardless of when the patient started MDT. CONCLUSIONS: Our findings suggest that, even when case detection is good, ocular pathology will still occur in MDT treated leprosy patients. There remains an important role for health workers in the prevention of ocular morbidity. Our data also demonstrated that pooling of results from all patients (newly diagnosed and on prior dapsone monotherapy) in a leprosy control programme will likely give rise to inadequate estimates of risk of ocular disease due to variable clinical disease histories in these groups.

Adult↗
PubMed1994

Traditional eye medicine use among patients with corneal disease in rural Malawi.

Over a 15 month period all patients with corneal ulcers presenting at two district hospitals were interviewed regarding demographic and clinical characteristics and their use of traditional eye medicines (TEM). Of the 583 patients interviewed, 33.8% reported using TEM. There were no age or sex differences in TEM use. Patients who reported TEM use took, on average, 51 days between onset of symptoms and presentation while patients who denied TEM use took 13 days. Sixteen per cent of TEM users had a vision in the affected eye of < 3/60 on presentation compared with 5% of non-TEM users. The frequent use of TEM and the presence of numerous traditional healers in rural areas of Africa suggest that eye care programmes could benefit greatly by including traditional healers in primary eye care activities.

Adolescent↗