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Biomedical subjects

P Cortina

Publications and source records attributed to P Cortina.

At least 37 records · Page 2Linked to original sources
PubMed1992

[Mortality from childhood and adolescent leukemia in Spain (1951-1985)].

PURPOSE: To study the mortality due to leukaemia during childhood and youth in Spain in the period 1951-1985. MATERIAL AND METHODS: The mortality for all types of leukaemia in that period was studied in three aspects: (a) By reviewing the rates of specific mortality for ages under 20 years, at quinquennial intervals and per millions of inhabitants of those ages. (b) Studying the mortality per cohorts of births at five-year intervals from 1951-1955 to 1981-1985. (c) Attaining the statistical value, "observed deceased" of leukaemia in people under 15 years of age for the period studied and on each year of that period, and comparing such value with the number of "expected deceased", with regard to the reference year, 1965. RESULTS: A decreasing trend was observed along the whole period. As for ages, there seems to be some tendency to stabilisation of the mortality in the last five-year period, 1981-1985 (there is a decrease only in the 15-18 age-group). These data were confirmed when assessing the mortality per "birth cohorts" or generations, and after plotting the figures of "observed" and "expected" mortality in accordance with the previous evolution. CONCLUSION: It was inferred that regard to the mortality of childhood and youth leukaemia, in Spain the situation has improved markedly, doubtless as a result of better therapeutical approach. This evolution closely resembles the patterns of the most developed countries from a sanitary standpoint.

Adolescent↗
PubMed1991

[Comparison of RAST with an immunoenzyme method in simultaneous determination of IgE specific for numerous air allergens].

Recently, a new immunoenzymatic test (Allergy Screen Profile, ASP) has been proposed for the simultaneous determination of IgE specific for five inhaled allergens (Dermatophagoides, animal dander, trees, grass pollen and Parietaria). For evaluation of this test we compared the results obtained in twenty-seven patients suffering from respiratory allergy with RAST with those obtained using the new test. In 84.3% of cases there was positive concordance between the two tests. The specificity of ASP ranged from 71.4% to 100% and the sensitivity from 76.9% to 95.2% for the different allergens examined. A good correlation between ASP and RAST was particularly evident for Dermatophagoides, animal dander and trees. Therefore, ASP appears to be a suitable test for the simultaneous determination of IgE specific for different allergens.

Adult↗
PubMed1991

Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance.

Twenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double-blind cross-over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross-over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry-over effect in the active-placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food intolerance.

Administration, Oral↗
PubMed1990

'Flagellate' erythema from bleomycin. With histopathological findings suggestive of inflammatory oncotaxis.

A case of erythema in a 'flagellate' pattern due to administration of bleomycin in a patient with Hodgkin's disease is described. Emphasis is placed on the low dose of bleomycin administered--15 mg parenterally--and the short time interval between drug administration and beginning of symptoms: 24 h. The histopathological findings were consistent with a mechanism of inflammatory oncotaxis: the attraction of tumor cells by the skin perhaps due to the bleomycin accumulated and the trauma caused by scratching subsequent to pruritus.

Adult↗
PubMed1989

Is the Melkersson-Rosenthal syndrome related to the exposure to food additives? A case report.

We present a case of Melkersson-Rosenthal syndrome that occurred in an adult patient who experienced intolerance to the food additives sodium benzoate and tartrazine. The main symptoms were the facial swelling, hypertrophy of the gums, and a typical infiltration of lymphocytes and plasma cells around the small vessels observed in the biopsy of the gums. No involvement of facial nerves was present, and other disorders of granulomatosis have been excluded. All clinical manifestations went into remission once the food additives were excluded from the usual diet.

Adult↗
PubMed1989

[Cancer of the testis: risk factors and evolution of mortality in Spain (1951-1983)].

Herein we report the results of a study on the mortality trends of testicular cancer in Spain from 1951-1983. The study showed that following a long period of increased mortality, overall mortality rates for all age groups have dropped in recent years. However, the mortality rate has increased for the young and middle-aged males and has dropped for the older age groups. A similar finding has been observed for other countries such as the United States. We have attempted to interpret these changes based on the risk factors for this type of cancer.

Age Factors↗
PubMed1989

[Treatment of Behçet's syndrome with colchicine].

The aim of the present study was to investigate the usefulness of colchicine in the treatment of Behçet's syndrome. Ten patients suffering from Behçet's syndrome were selected for this purpose. The patients were treated with 1 mg/day of colchicine associated with 1 mg of betametasone during the initial florid phase of the disease. After the acute phase, betametasone was withdrawn. The patients were observed for a period ranging from 5 to 23 months. Biochemical and immunological parameters were measured at time 0 and every month in order to monitor the disease and the possible side effects of colchicine. All patients had a satisfactory control of the disease without showing any toxic effect.

Adult↗
PubMed1989

[Migraine and food].

The frequency of migraine has been studied in adult patients with suspected adverse reaction to foods. Migraine was present in 41 out of 300 patients (13.6%). 38 of these 41 subjects have been treated with elimination diet; 25 (65.7%) obtained a significant improvement of migraine and subsequently, performed challenge test. 24 patients were affected by food intolerance and only one by food allergy. The remaining 13 non-responder subjects suffering from migraine have been subsequently submitted to pharmacological treatment.

Adult↗
PubMed1987

Psychiatric morbidity in an Italian general practice.

A two-stage screening strategy was applied in a single-handed general practice in northern Italy. The study was designed so that all the second-stage psychiatric interviews were conducted during the first phase of the study (group A patients), while self-report questionnaire (GHQ) and GP assessments only were collected during the second phase (group B patients). The estimated true case rate of psychiatric disorder (36%) did not differ between the two phases of the study, but there were marked differences in the general practitioner's diagnostic behaviour. During the first phase (when psychiatric interviews were being conducted in the practice), her behaviour was heavily biased towards diagnosing psychiatric disorder; 61% of the patients were regarded by her as psychiatric cases and the hidden psychiatric morbidity rate was only 9%. During the second phase of the study (no psychiatric interviews in the practice), only 37% of the patients were regarded as psychiatric cases by the GP, and the hidden morbidity rate was 59%. The results are interpreted as demonstrating that the presence of a psychiatrist conducting a two-stage screening survey in the practice had a profound effect on the diagnostic threshold. They also provide support for the use of the GHQ as a case-finding instrument in general practice.

Adult↗