Biomedical subjects

P Contencin

Publications and source records attributed to P Contencin.

57 records · Page 4Linked to original sources

PubMed1982

[Treatment of carcinomas of the vallecula and epiglottis by supraglottal surgery. Indications and therapeutic results].

A study of 87 cases of carcinoma of the vallecula and the epiglottis (margin and vestibulum) with the common feature of an essentially identical surgical technique: supraglottal horizontal laryngectomy. In the case of vallecular lesions (34 cases from T1 to T4) this operation, performed from below upwards with lymph node dissection and associated with postoperative radiotherapy, gave oncological results identical to those of total laryngectomy and better than those of other protocols based upon radiotherapy. From a functional standpoint, despite two deaths due to bronchopneumonia, with careful respect paid to local and general contraindications there were no prolonged problems, even if the postoperative course was somewhat longer in lesions of the epiglottis. Carcinomas of the epiglottis (53 cases) did not receive radiotherapy where resection was adequate and lymph node histology negative. The results, better than in those cases involving the vallecula, seemed to be identical to those published in the literature. Such partial surgery, with preservation of the voice, should thus be beneficial in patients suffering from such lesions, in particular when the larynx is unaffected.

Adult↗

PubMedDate not supplied

Dual-probe pH monitoring for the assessment of gastroesophageal reflux in the course of chronic hoarseness in children.

The purpose of our study was to assess gastroesophageal reflux (GER) by dual-probe pH monitoring in children suffering from chronic hoarseness for more than six months. Seventeen children (aged between 2 and 12 years, 10 boys and 7 girls) were enrolled. All children underwent a laryngoscopy and a 24-hour dual-probe pH monitoring. At both sensor, distal and proximal esophageal, a pathological GER was defined as the presence of episodes of acid reflux with pH < 4 during a fraction of the total recording time greater than 5.2 percent. The computer considered the child was supine when asleep and upright when awake. Laryngoscopy revealed interarytenoid erythema and/or edema with vocal cord nodules or granulomas in 13 cases (76.4%), isolated vocal nodules or granulomas in three cases (17.6%) and a normal appearance in one case (5.8%). At both sensors, the majority of refluxes occurred when the child was upright, as analyzed by the percentage of time the intra-esophageal pH was below four (% time pH < 4), number of refluxes, reflux episodes/hour and longest reflux episode, p < 0.05 between upright and supine for each parameter. The median total % time pH < 4 on the proximal and distal probes was respectively 1.62 percent (95% CI 1.50-3.79) and 11.49 percent (95% CI 8.81-27.17), p < 0.0003. Among the 17 hoarse children, a pathological GER was observed in 12 (70.5%) at the distal sensor and in three (17.5%) at both sensors. Among the 16 hoarse children with abnormal findings on laryngoscopy, two (12.5%) had diagnosed pathological GER at the proximal and 11 (68.7%) at the distal sensor. The only child with normal findings on laryngoscopy exhibited a pathological GER at both sensors. Our results suggest that chronic hoarseness is associated with a pathological GER. The majority of these documented refluxes occurred when the child was awake.

Child↗

PubMedDate not supplied

[Measurement of pH of the rhinopharynx in children with gastroesophageal reflux].

The relationship between gastro-oesophageal reflux and inflammatory airway pathology is well known as regards the trachea and bronchi. It is disputed by some authors but clearly established by others as regards the pharynx and larynx (recurrent laryngitis, subglottic stenosis, laryngospasm). A number of authors have empirically observed that gastro-oesophageal reflux is associated in some cases with chronic inflammation of the rhinopharynx and middle ear. We studied the 24-hour pH of the rhinopharyngeal mucosa in 3 groups of children: 3 healthy children acting as controls, 1 child with known gastro-oesophageal reflux but without rhinopharyngeal pathology, and 2 children with both gastro-oesophageal reflux and mucosal obstruction of the nose and pharynx unascribable to the usual causes. Minimal to considerable variations of rhinopharyngeal pH were observed in children of the third group, while controls had a remarkably stable 24-hour pH (6.7 to 7.4 depending on the subject). Owing to the small number of cases studied, these results should be regarded as preliminary and devoid of significant value concerning the real impact of the acid reflux on rhinopharyngeal pathology.

Female↗