[Ultrastructure at the initial onset of trachoma].
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Biomedical subjects
Publications and source records attributed to P Comte.
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A 32-year-old female with alcoholic cirrhosis attempted to drown herself in a pond. She remained in a coma for 57 days. After a stormy course she developed multiple brain abscesses due to Scedosporium (Monosporium) apiospermum. Despite intravenous and intrathecal amphotericin B (total dose 870 mg) the patient died 71 days after the near drowning.
The authors report a case of intracranial fungal aneurysm and brain abscesses. The compromised host was a young drowned woman. Scedosporium Apiospermum was isolated in fungal culture from abscess. Radiological and clinical pictures are typical of the hyphal form.
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A multicontact macroelectrode for brain recordings is described. Its hollow-core structure and slightly recessed contacts allow the electrode to be guided with a central stylet for minimal tissue trauma. The helical design of the electrode is characterized by high fatigue resistance and high flexibility allowing movement with the brain and preventing slicing through tissue. Clinical results have been obtained on epileptic patients.
A new technique for deep-brain electrode implantation is described. A very flexible nontraumatic electrode guided by a central stylet and a new electrode head-fixation screw are the two unique features of this system. Electrodes can be guided precisely and their watertight fixation to the bone by means of the special screw is reliable and totally reversible. The system has been designed to fit most of the stereotaxic frames currently in use.
Regression of Urrets-Zavalia's syndrome was obtained in one case after treatment administered according to a strict sequence following keratoplasty for keratoconus: sympatholytic drops (guanethidine 5%-Ismelin) every 4 hours for 24 hours, followed the next day, when mydriasis had been slightly reduced, by parasympathomimetic drops (pilocarpine 2%). Marked myosis was observed and treatment discontinued. This resulted in recurrence of the mydriasis, but this was successfully treated by repeating therapy. Pilocarpine drops were progressively diminished, followed by a slow reduction of guanethidine drops over 8 weeks, resulting in only slight residual anisocoria. This treatment is based on the physiopathological concept of sympathetic spasm with parasympathetic inhibition, and it is suggested that reduction of spasm should be obtained before administration of therapy to stimulate the sphincter. Pharmacological data on the compounds employed are discussed.
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