Search PubMed⌕ Search

Biomedical subjects

P Collins

Publications and source records attributed to P Collins.

At least 397 records · Page 22Linked to original sources
PubMed1966

Importance of carbon dioxide in the isolation of pneumococci.

Austrian, Robert (The University of Pennsylvania School of Medicine, Philadelphia), and Patricia Collins. Importance of carbon dioxide in the isolation of pneumococci. J. Bacteriol. 92:1281-1284. 1966.-Of the strains of pneumococci isolated from man, 8% manifest a requirement for CO(2) if detectable growth is to occur on the surface of solid media. The pneumococci most frequently manifesting this requirement are types I, III, XVI, XXVIII, and XXXIII. These strains will grow in the presence or absence of oxygen provided the atmosphere in which they are incubated contains CO(2). Review of published data provides no unequivocal evidence for the existence of anaerobic pneumococci.

Carbon Dioxide↗
PubMedDate not supplied

Comparison of diets high in monounsaturated versus polyunsaturated fatty acid on postprandial lipoproteins in diabetes.

BACKGROUND: Postprandial hypertriglyceridaemia is common in diabetes. Fatty acids are regulators of gene expression and may play an important role in regulatingthe postprandial lipoprotein cascade. AIM: To examine postprandial lipoprotein differences between diabetic and control subjects on polyunsaturated (linoleic) and monounsaturated (oleic) fat diets. METHODS: A randomised, crossover study. RESULTS: LDL was greater and HDL less (p < 0.05) in diabetic patients compared to controls on the linoleic acid diet. Apo E per particle was significantly lower in the diabetic patients compared to control subjects on both linoleic (p < 0.05) and oleic acid diets (p < 0.01). HDL apo E was also significantly lower in the diabetic patients compared to controls on the linoleic acid diet (p < 0.02). CONCLUSION: A change from linoleic to oleic acid diet resulted in an improvement in LDL and HDL in the diabetic patients. We suggest that the reduced apo E/particle in the diabetic patients may be an explanation for the delayed lipoprotein clearance.

Case-Control Studies↗
PubMedDate not supplied

Oral chemotherapy of fatal B virus (herpesvirus simiae) infection.

Acyclovir and ganciclovir, which were only about 10-fold less effective against B virus than herpes simplex virus type 1 in VERO cells, were tested in vivo in B virus-infected rabbits. Untreated control rabbits became paralysed from 8 days and died from 10 days. Oral acyclovir at a dose rate of 500 mg/kg/day for 21 days prevented death; acyclovir prevented disease at 700 mg/kg/day. In B virus-infected humans such a high dose of acyclovir could not be given by mouth. Nevertheless, high dose oral acyclovir is suggested for immediate prophylaxis when monkey handlers have been exposed to potentially fatal B virus infection. Should signs or symptoms of disease occur then high dose intravenous acyclovir has been recommended. Since ganciclovir was found to be more effective than acyclovir, intravenous ganciclovir might be preferred for the treatment of established infection.

Administration, Oral↗
PubMedDate not supplied

Effect of fat and carbohydrate consumption on endothelial function.

Consumption of a meal high in monounsaturated fat was associated with acute impairment of endothelial function when compared with a carbohydrate-rich meal. Such a divergent response in endothelial function may be important in the modulation of vascular function in health and disease.

Adult↗