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Biomedical subjects

P Clark

Publications and source records attributed to P Clark.

At least 271 records · Page 15Linked to original sources
PubMed1977

Compliance and resistance in autistic children.

The study was designed to explore factors related to negativism in autistic children, where negativism was defined as the consistent avoidance of a correct response in a multiple choice discrimination task. A design employed in an earlier study of autistic children (Cowan, Hodinott, & Wright, 1965) was modified to allow a more detailed examination of patterning of the child's responses. A positive relationship was found between use of spoken language and successful performance of the task. However, no child was negativistic. Of the 27 children tested, 18 had a near perfect performance and 9 scored at chance level. A subsequent exact replication of the Cowan et al. method still failed to produce any negativism. A further study using a more difficult discrimination task produced a higher rate of errors but still no negativism. Possible reasons for the failure to replicate are discussed.

Adolescent↗
PubMed1977

Subcapsular orchidectomy for carcinoma of the prostate.

Our results suggest that subcapsular orchidectomy is at least as effective as oestrogen therapy in producing long-lasting suppression of plasma testosterone. It has many advantages over oestrogen therapy, so that, like Huggins, we believe it to be the hormonal treatment of choice for patients who develop symptoms from carcinoma of the prostate.

Castration↗
PubMed1976

Re-implantation of the ureter.

For 10 years a modified Politano-Leadbetter technique with extravesical as well as intravesical exposure has been used for re-implantation of the ureter. The results suggest that the passive mechanism of prevention of reflux is more important than any active mechanism and that it is unnecessary to excise the lower end of the ureter.

Adolescent↗
PubMed1976

Isozymes of glyceraldehyde-3-phosphate dehydrogenase in man and other mammals.

Multiple electrophoretically distinct forms of glyceraldehyde-3-phosphate dehydrogenase have been observed in human and other mammalian tissues. The human isozymes appear to have essentially the same structural and kinetic properties. An apparent correlation between red-cell age and the relative intensities of the isozymes supports the idea that the isozymes arise as a result of post-translational modification of the polypeptide chain. The possibility that a second locus is involved in the determination of these isozymes is discussed.

Adult↗
PubMed1975

HL-A antigens in congenital rubella and the role of antigens 1 and 8 in the epidemiology of natural rubella.

Study of 87 patients (53 adults, 23 males; 34 children, 18 males) with congenital rubella revealed an increased incidence of several HL-A antigens, including HL-A5, HL-A1, HL-A3 and HL-A8, the frequency of HL-A1 being raised because of the statistically significant increase of this antigen in the adult female subjects compared with normal controls. Correlation of the level of seropositivity to rubella virus in 29 normal adult populations, according to racial origin and geographic location, with the frequency of various HL-A antigens revealed the most significant association with HL-A1 (r equals 0.71). It is suggested that the presence on the cell surface of HL-A1 or the combination of HL-A1 and 8 may fovour rubella virus infection.

Adult↗
PubMed1975

Nephroscopy.

Nephroscopy is a simple and valuable procedure, which may be used to differentiate between stones within the calyces of the kidney and calcification in the pyramids and to locate stones and stone fragments. The ordinary ifnant panendoscope is a suitable instrument to use.

Endoscopes↗
PubMed1975

Effects of task difficulty on subsequent preference for visual complexity.

Ss rated on a 1 to 13 Likert scale their preference for four environmental scenes which differed in complexity. Ss were then given 30 sec. to solve each of 10 3-, 5-, or 7-letter single-solution anagrams. Finally the Ss rated four new slides which were of the same complexity level as the slides seen during the first session. Change scores were calculated by subtracting the preference ratings at each complexity level during the first session from the rating at the corresponding complexity level during the second session. The Anagram Complexity X Slide Complexity interaction was significant: the complexity of the slides showing the most positive change scores was inversely related to the complexity of the anagrams attempted. The results were discussed in terms of optimal level of stimulation theories.

Arousal↗