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Biomedical subjects

P Canlorbe

Publications and source records attributed to P Canlorbe.

125 records · Page 7Linked to original sources
PubMedDate not supplied

[Responses of somatotropin to stimuli after brief administration of estradiol in short children].

Ethinyl estradiol has been administered orally, 100 micrograms per day during three days, to enhance the growth hormone (GH) response to usual pharmacological stimuli. 102 prepubertal short patients aged 2 to 17 years with height between 2 to 6 SD below the mean, were studied. Human growth hormone (hGH) treatment was given only to those patients whose GH response was still below 10 ng/ml after estradiol. Under hGH treatment, their growth rate increased twofold, as much in patients with partial GH deficiency as in those with complete GH deficiency. It is concluded that the lack of GH response after estradiol priming contributes to the assessment of the indication for treatment with hGH. However, since it has not been possible to give this treatment to very short children whose GH response became normal after priming, this study does not allow to preclude the effect of hGH in such conditions. Thus estradiol priming must not be included among the practical criteria leading to therapeutic decision in doubtful cases.

Adolescent↗
PubMedDate not supplied

[Cryptorchism].

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Adolescent↗
PubMedDate not supplied

[The progeny of women with treated congenital hypothyroidism (author's transl)].

The progeny of 11 women with treated congenital hypothyroidism was studied. They had 17 pregnancies that led to 2 spontaneous abortions, 2 children dead in the first month after birth, and 13 living children. These 13 children have a normal psychomotor development. One of them has a lingual ectopic thyroid as her mother, one has a congenital cardiac defect, one has a minor anomaly of toes. The authors add a previously reported familial case of hypothyroidism in a mother and her four children.

Congenital Hypothyroidism↗
PubMedDate not supplied

[Puberty and adult height in congenital virilizing adrenal hyperplasia (author's transl)].

A study of 52 pubertal patients having been treated for virilizing adrenal hyperplasia (38 females and 14 males) leads to emphasize the importance of the precocity and accuracy of treatment. In patients with delayed treatment, mainly when they are girls, an advanced or true precocious puberty will increase the advance of bone age and reduce adult height. But, whatever be the time of onset of treatment and of pubertal achievement, no important or sustained sexual improvement was found in patients receiving a well-controlled treatment.

Adolescent↗
PubMedDate not supplied

[Final results of treatment with human growth hormone].

The authors report the results of treatment with human growth hormone (hGH) (for 3 1/2 years to 11 3/4 years, mean: 5 years 4 months) in 34 children presenting with complete growth hormone deficiency and an average growth failure reaching 3.9 standard deviations (SD). Treatment was discontinued, after spontaneous or induced puberty, when bone age reached or was beyond 15 years in boys, and 13 years in girls. A partial correction was obtained in almost all cases. However, average height remained at -2.4 SD with respect to age and -1.75 with respect to bone age, reaching normal limits in only half of the patients. School and professional performances were not appreciably different from those which are observed in normal adolescents. Although the acceptance of the diagnosis and therapy was not always good, the medical support associated with the supervision of the treatment seems to have had a favourable psychological effect.

Adolescent↗