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Biomedical subjects

P Camner

Publications and source records attributed to P Camner.

At least 145 records · Page 8Linked to original sources
PubMed1976

Tracheobronchial clearance and beta-adrenoceptor stimulation in patients with chronic bronchitis.

The effect of a beta-adrenoceptor stimulating agent, terbutaline, on mucociliary transport in the lungs was studied in 10 patients with chronic bronchitis. Mucociliary transport was studied by having the patients inhale 6mum teflon particles tagged with 99mTc and by external measurement of the radioactivity in the lungs in the supine position. Terbutaline 0.25 mg and vehicle respectively were given subcutaneously in a cross-over double-blind study. On the average, clearance was slow in the examinations where the patients were given vehicle. Terbutaline produced a marked increase in mucociliary transport in four patients, a smaller increase in one and no effect in the others. Three out of the four patients who showed a marked inrease in clearance had less ventilatory impairment than the other seven patients. This may indicate that the mucociliary transport mechanism is less severely damaged in relatively early stages of the disease than in later stages. On the average FEV1.0 deteriorated significantly during the clearance measurements when vehicle was given, but did not change significantly when terbutaline was given.

Adult↗
PubMed1976

Tracheobronchial clearance in bronchial asthma: response to beta-adrenoceptor stimulation.

Tracheobronchial clearance was studied in 12 patients with bronchial asthma. They inhaled a test aerosol of 6 mum teflon particles tagged with 99mTc, after which external measurement of the radioactivity in the lungs was made for 2 h in the supine position. Clearance was determined after subcutaneous administration of 0.25 mg of the beta-adrenoceptor stimulating compound terbutaline and vehicle, respectively, in a crossover, double-blind study. The average clearance in the asthmatics did not differ significantly from that of healthy non-smokers. Terbutaline significantly enhanced clearance in the asthmatics, though considerably less than reported for healthy subjects. Alternative explanations for this weak effect of terbutaline in the asthmatics might be that the mucociliary transport system was affected by the asthma disease, or that earlier treatment with beta-adrenoceptor stimulating compounds or other drugs had produced increased tolerance and/or carry-over effects. Ventilatory function measured as FEV1.0 deteriorated significantly during the clearance measurement when vehicle was given, but not when terbutaline was given. Terbutaline thus counteracted the unfavourable effect of the supine position on ventilation.

Adult↗
PubMed1975

Evidence of congenitally nonfunctioning cilia in the tracheobronchial tract in two subjects.

Mucociliary transport in the tracheobronchial tract was studies in 2 subjects by having them inhale a radioactively tagged test aerosol and by taking external measurements of the radioacitivity in the lungs for 2 hours. Both subjects had living, yet immotile seprmatozoa; the sperm tails lacked normal dynein arms, which are essential for the bending movements of sperm tails as well as of other cilia. The subjects were classified as suffering from Kartagener's syndrome (situs inversus, chronic sinusitis, and bronchiectasis) and were shown to have an extremely slow, probably absent transport. The results of the study were in agreement with a recent hypothesis explaining Kartagener's syndrome as due to a genetic lack of dynein arms. An estimate of the importance of mucociliary transport as a protective mechanism of the lung may be possible by examining patients suffering from Kartagener's syndrome.

Adult↗
PubMed1975

The influence of a carbachol aersol on the tracheobronchial deposition of 99mTc tagged particles.

The tracheobronchial deposition of inhaled 99mTc tagged teflon particles of 6 mum (specific density 2g/cm3) was determined in rabbits by comparing the particle content in free dissected parts of the tracheobronchial tree with that in the whole lung. There was a singificantly larger deposition of particles in the proximal parts of the airways in rabbits exposed to an aerosol of the bronchoconstrictor compound carbachol than in control rabbits exposed to distilled water alone. The resistance to insufflation of a constant volume of air increased during the exposure to the carbachol aerosol, indicating bronchoconstriction. There was reproducible interindividual differences in bronchoconstrictor response to the carbachol aerosol. They were attributed to interindividual differences either in deposition of carbachol or in bronchial muscle sensitivity to carbachol. It is concluded that bronchoconstriction might serve as a defensive measure in causing a more proximal deposition of inhaled particles.

Aerosols↗