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P Cameron

Publications and source records attributed to P Cameron.

At least 73 records · Page 4Linked to original sources
PubMed1986

Antibodies of predetermined specificity to the major charged species of human interleukin 1.

The development of highly specific antisera to human interleukin 1 (IL-1) has been an elusive goal hampered mainly by the availability of only limited amounts of pure immunogen. To surmount this difficulty, three peptides of the major charged species of IL-1 (pI 6.8) were synthesized and covalently coupled to keyhole limpet hemocyanin (KLH). All three peptide-KLH conjugates raised rabbit heterologous antisera that bound intact pure IL-1 in a dose-dependent and domain-specific manner. Immunoblot analysis of crude concentrated culture supernatants with these antisera showed each of them to be highly specific for mature 18-kDa IL-1. Immunoblot analysis of monocyte lysates revealed a single 33-kDa band consistent with the size of the IL-1 precursor molecule deduced from cloned cDNA. These reagents should prove to be valuable tools in the localization and measurement of IL-1 in cells and fluids and may permit the separate study of individual IL-1 species as well as discrete domains of intact IL-1 molecules.

Animals↗
PubMed1986

Psychiatric training and the trainee: is there a fit?

This data would suggest that psychiatric training programs may not be organized according to the interest or needs of many trainees. The emphasis on fulltime research in neurobiological psychiatry is centre stage in most programs, and yet according to our survey, few residents view this as a desirable career path. Our data from 8 years of trainees at the University of Toronto indicates that a new model of training streams would best suit the needs of the trainee, the profession and the community. This report is a continuation of a study into the recruitment process. An earlier report was published in the Canadian Journal of Psychiatry Vol. 29, December 1984. Our present data is on two groups of trainees as well as from faculty.

Canada↗
PubMed1985

Amino acid sequence analysis of human interleukin 1 (IL-1). Evidence for biochemically distinct forms of IL-1.

The pI-6.8 species of normal human interleukin 1 (IL-1) has been isolated by ion-exchange and reverse-phase high-performance liquid chromatography. The isolated material had a molecular weight of 18,000, and had a specific bioactivity of 1.7 X 10(7) half-maximal U/mg in the murine thymocyte proliferation assay, values similar to those obtained for murine P388D1-derived IL-1 (12), and human IL-1 isolated by a previously published purification protocol (15). Amino-terminal sequence analysis revealed a single N-terminal, and resulted in the identification of 30 of the first 35 amino acid residues. Sequence of three CNBr cleavage fragments of purified IL-1 resulted in the identification of an additional 38 residues. All of the sequences agree exactly with those deduced from complementary DNA (cDNA) by Auron, et al. (18), demonstrating that this cloned cDNA, though considerably different from the cDNA reported for murine IL-1 (12), nevertheless codes for the pI-6.8 species of human IL-1. The evidence also shows that the precursor protein for human IL-1 is largely processed at the N-terminal end. Little or no processing occurs at the carboxy-terminal end. Sequence homology with interferon-inducing factor (26) suggests that the pI-6.8 species of human IL-1 is a member of a gene family. Although equally potent in the murine thymocyte proliferation assay, murine IL-1 and the pI-6.8 species of human IL-1 are structurally distinct. Further study will answer the interesting question as to the relationship of the other charged species of human IL-1 to these distinct IL-1 classes.

Amino Acid Sequence↗
PubMed1984

Pharmacokinetics of cimetidine in critically ill patients.

Cimetidine disposition was studied after rapid (1 min) intravenous infusion in eight critically ill patients aged between 20 years and 77 years; one patient was studied on two occasions. Cimetidine dose was 300 mg in seven patients and 400 mg in the remaining patient. Arterial plasma cimetidine concentrations at the end of the infusion were very high and ranged from approximately 15-35 mg/l. Pharmacokinetic parameters displayed wide interpatient variability (coefficients of variation of 30-50%) and significant relationships emerged between some of these parameters and certain patient characteristics. Most notable, total systemic plasma clearance of cimetidine was directly related to estimated creatinine clearance (p less than 0.01). This relationship might prove to be a useful method of individualizing cimetidine dosage in critically ill patients.

Adult↗
PubMed1984

Recruitment into psychiatry: a study of the timing and process of choosing psychiatry as a career.

This is a study of the timing and process of choosing psychiatry as a career. All the psychiatric residents in the Department of Psychiatry, University of Toronto in the academic year 1981-1982 were surveyed. Seventy-eight percent (93 residents) responded. We found that 58.1% had decided to enter psychiatry after graduation from medical school. Of the total group 27% came from family practice programs; 14% of our sample had decided on a career in psychiatry before entering medical school. In our study, 27.9% of the sample decided to choose psychiatry during medical school. The factors which appear influential in determining the choice of psychiatry as a career were interest in psychosocial problems, rejection of other specialties, discovery of prevalence of psychosocial problems in family medicine and other specialties, discovery of effectiveness of psychiatric therapies and the experience of personal psychiatric therapy (23.6%). There is a suggestion that the previous decline in recruitment has been checked and that recruitment is now increasing. The authors discuss recruitment strategies that may increase the selection of the most desirable candidates into psychiatry. If undergraduate teaching emphasized the effectiveness of therapeutic intervention, it is probable that more interested candidates would choose psychiatry earlier.

Adult↗
PubMed1982

And coffee too.

Two hundred and seventy-two persons aged 11 to 80 were interviewed regarding whether and why they had tried and/or used coffee, tobacco, liquor, and marijuana. The attracting and capturing power of tobacco and marijuana registered as lower than those associated with coffee and liquor. A guilt/shame index was derived from avowed motives. Trying tobacco and liquor was associated with greater guilt/shame than that associated with coffee and marijuana. Most tobacco users offered motives that indicated continued guilt/shame, while the majority of the other users expressed contentment with their habits.

Adolescent↗
PubMed1979

Psychopharmacology education in psychiatry.

This study has documented resident dissatisfaction with education in psychopharmacology in one large university and has proposed several solutions. These include: - increased awareness of standards of knowledge necessary for a consultant. - the establishment of a central educative office of clinical psychopharmacology to encourage dissemination of selected literature and to facilitate residents' research under supervision. - recognition that not all staff should be considered capable to provide psychopharmacology supervision and that each hospital should have a designated psychiatrist with special expertise in psychopharmacology. - developing study groups for the purpose of teaching critical evaluation of the literature. - increasing encouragement for residents' participating in clinical research - awareness of residents' difficulties in learning "emotional illness, rejection of biological therapies, and knowing what is expected or not suited to psychiatry" and appropriate actions to alter these. - increased use of audio aids, self-teaching manuals and journals to augment lectures and texts. - increased emphasis on training selected senior residents in how to teach.

Humans↗
PubMed1976

Masculinity/femininity of the generations: as self-reported and as stereotypically appraised.

Three hundred seventeen adults divided among the younger adult, middle aged, and old generations were asked (a) to judge which of the three generations was most and least masculine/feminine in overall personality style, masculine/feminine in interests and possession of gender skills, and pressured by society to do masculine/feminine sorts of things; and (b) to rate self along each of these dimensions on a Likert scale. Self-reports and beliefs about the generations did not vary as a function of membership in a generation. Young adults and middle aged were belived to be the most feminine and middle aged the most masculine in overall personality style. The middle aged were judged as possessed of the most feminine and masculine interests and the most skilled in feminine endeavors. Middle aged and young adults were judged equally possessed of masculine skills. Social pressure to do masculine and feminine activities was seen as falling equally heavily on younger adults and middle aged. The old were judged as next-most possessed of feminine skills while judged least along the other dimensions.

Adult↗
PubMed1975

Mood as an indicant of happiness: ags, sex,social class, and situational differences.

Does mood vary as a function of age, sec, or situation? In four investigations, 6,452 persons aged 4 to 99 were interrupted at leisure, at home, at school, and at work and asked to assess their mood as being happy, neutral, or unhappy. Moods of happiness and neutrality were each reported about 45% and unhappiness about 10% of the time. Females more frequently reported moods of happiness or unhappiness than males, while mood did not vary as a function of age. Persons at leisure reported more affectively pleasant moods than those at work, at home, or at school. Persons of higher socioeconomic status reported more happy moods than those of lower status. In another study, a class of 255 students was administered various personality scales and then interrupted 21 times over the course of the quarter and their mood indexed. Tested religiosity negatively correlated with frequency of pleasant moods, the Barron Ego-Strength Scale was uncorrelated with frequency of kind of mood, and the Eysenck Neuroticism Scale correlated with frequency of unpleasant moods.

Adolescent↗
PubMed1975

Nutrition in the Australian aborginines--effects of the fortification of white flour.

The nutritional status of 66 part Aborginines was re-examined in 1974--with particular reference to blood levels of haemoglobin and vitamins--after white bread fortified with iron and the vitamins B1 and PP (niacin) had been available for six and half months to the population of Bourke, New South Wales. The results found in 1971 and 1974 are compared. A significant improvement from deficient to acceptable blood levels of vitamins B1 and B6 was found in 44% and 52% of the subjects respectively. This attributed to the comsumption of fortified bread since the levels of the other vitamins had remained either unchanged or worsened. The biochemical improvement in vitamin B6 is attributed to the sparing effect of vitamin PP on vitamin B6 requirement because the conversion of tryptophan to niacin is impaired in vitamin B6 deficiency. Iron deficiency anaemia in children had decreased by 50% but this could have been due to many other factors besides the iron which had been added to the bread. Clinically there was a marked decrease in angular stomatitis and skin xerosis which could be related to the biochemical improvement of the two B-vitamins and a decrease in active trachoma and suppurative otitis media probably due to intensive treatment received since 1971. The results of this study and the extent of biochemical vitamin B1 and B6 deficiency found in other groups, indicate that fortification of bread may be of benefit to the community as a whole.

Adolescent↗