Community psychiatric services.
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Biomedical subjects
Publications and source records attributed to P Calloway.
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The distribution of scores in the Mini Mental State Examination (MMSE) of women aged 70-79 years from a rural area of Cambridgeshire is reported. Increasing age, lower socioeconomic group and less education were all found to be associated with lower scores on MMSE. Of these, only increasing age was significantly related to an increase in the diagnosis of dementia.
It has been suggested that serum creatine kinase levels might be useful in the investigation of dementia. In this study serum creatine kinase BB (CKBB) isoenzyme levels were investigated in a community population of elderly women aged 70 to 80 years. Normative data for this group were compared with the findings in younger age groups. No relationship was found between levels of CKBB and level of dementia, or with the specific clinical diagnosis of senile dementia of the Alzheimer type, although a weakly positive relationship was found between CKBB and 3 cognitive scales.
A study of 365 women aged 70-79 in a rural community was carried out using the Cambridge Examination of Mental Disorders in the Elderly (CAMDEX). Prevalence rates of dementia are reported by severity for the 70-74 and 75-79 age groups. Differential diagnosis was made according to CAMDEX guidelines. Senile dementia of Alzheimer type accounted for half the dementia cases. The prevalence rates overall did not differ from those reported in other recent studies, but the rates for levels greater than mild/moderate were lower, despite the inclusion of subjects in institutions.
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There is little evidence to support the view that senile dementia of the Alzheimer's type (SDAT) is distinct from the normal ageing process. The changes in brain function found in normal ageing, benign senescent forgetfulness, and SDAT can be seen as a continuum, which may reflect a single underlying process. The failure to account for this possibility in research design may explain why few risk factors for SDAT have been identified.
Autonomic arousal, measured by skin conductance level and response, was examined in 36 female patients with eating disorders (anorexia nervosa and bulimia nervosa) and 32 control subjects. No differences were found between the control group and anorexics who lost weight solely through dieting (restricting anorexics). Patients with a diagnosis of bulimia nervosa and anorexics with bulimic features, however, showed fewer spontaneous skin conductance responses and were faster to habituate to 85 dB tones than either controls or restricting anorexic patients. The pattern of findings supports recent views concerning the clinical subdivision of anorexia nervosa.