Search PubMed⌕ Search

Biomedical subjects

P C O'Brien

Publications and source records attributed to P C O'Brien.

366 records · Page 21Linked to original sources
PubMedDate not supplied

Use of beef ultralente for basal insulin delivery: plasma insulin concentrations after chronic ultralente administration in patients with IDDM.

Ultralente has been used as the basal component of intensive insulin therapy programs. To determine the degree to which a single daily subcutaneous injection of beef ultralente provides stable basal insulin concentrations, plasma free insulin concentrations were measured in six insulin-dependent diabetic patients over a 40-h period. All short-acting insulin was withheld during this interval. Each patient had been maintained on a chronic ultralente based program before study. Little if any evidence of a temporal peak in plasma insulin concentrations was observed. Although considerable variation in plasma insulin concentrations was observed in one individual, beef ultralente provided relatively stable plasma insulin concentrations in the group as a whole. Beef ultralente appears to be a reasonable insulin preparation to use as the basal component in an intensive insulin therapy program.

Adult↗
PubMedDate not supplied

Correlations of plasma concentrations of B-cell polypeptides with pathologic features of insulinomas.

OBJECTIVE: To assess the correlations between plasma concentrations of b-cell polypeptides (insulin, C peptide) and size, multiplicity, and malignancy of insulinomas. METHODS: We retrospectively reviewed the medical records of 55 consecutively treated patients at our institution with surgically confirmed insulinoma. The 29 female and 26 male patients ranged from 13 to 77 years of age (median, 46). Plasma insulin, C peptide, proinsulin, and glucose concentrations were analyzed statistically in patients with benign and those with malignant insulinomas. RESULTS: Significant correlations were observed between plasma insulin and tumor size (r = 0.45; P = 0.001) and tumor volume (r = 0.41; P = 0.007) and between plasma C peptide and tumor size (r = 0.38; P = 0.004) and tumor volume (r = 0.33; P = 0.025). No differences between benign and malignant tumors were noted for plasma insulin, C peptide, glucose, nor tumor size or volume. No correlations were found between plasma insulin, C peptide, or glucose and number of tumors. CONCLUSION: The plasma levels of insulin and C peptide provide qualitative indications about the size of insulinomas.

Journal Article↗
PubMedDate not supplied

Ureaplasma urealyticum in semen for artificial insemination: its effect on conception and semen analysis parameters.

Semen specimens from 24 donors in an artificial insemination program--selected for women whose infertile status was determined to be male factor-related and for whom no female factor could be determined--were cultured for the presence of Ureaplasma urealyticum. A life table statistical analysis indicated that conception did not occur sooner in the U. urealyticum-negative group (n = 14) compared with those women inseminated with the U. urealyticum-containing semen (n = 10). In addition, no significant differences were detected in semen analysis count, grade, or motility between semen with or without U. urealyticum. We found no differences in the occurrence of fetal morbidity or mortality in ten conceptions between the women impregnated with Ureaplasma-positive (n = 14) and Ureaplasma-negative (n = 6) semen. Thus, our study does not support the role of U. urealyticum as a cause of male factor-related infertility or early pregnancy loss.

Actuarial Analysis↗
PubMedDate not supplied

Computer assisted sensory examination to detect and quantitate sensory deficit in diabetic neuropathy.

In this report we describe computer assisted systems to evaluate cutaneous sensation to detect raised thresholds of cutaneous sensation. Normative data has been obtained so that thresholds are known for face, hand and foot. Results show that thresholds vary with site, age, and sex. Among more than 100 diabetic patients whose vibratory, touch-pressure and thermal cooling thresholds were evaluated a raised threshold was demonstrated in 49%, 37% and 33%, respectively. This provides helpful knowledge for protocol trials of diabetic neuropathy. Because these approaches provide sensitive and reliable evaluation of deficits of cutaneous sensation not possible with rapid and inexpensive approaches, we suggest that they might find a place in neurotoxin surveillance.

Age Factors↗