Biomedical subjects

P C Jenkinson

Publications and source records attributed to P C Jenkinson.

20 records · Page 2Linked to original sources

PubMedDate not supplied

Metaphase analysis of human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.

4CMB and BC caused mitotic inhibition in human lymphocytes at low doses (greater than 20 and greater than 10 microgram/ml respectively). At non-inhibitory concentrations, neither substance produced increases in cells with breaks or breaks per cell, although 4CMB did induce a significant increase in gaps at dose. 4CMB and BC are not chromosome mutagens in this system.

Benzyl Compounds↗

PubMedDate not supplied

Sister-chromatid exchanges in human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride.

At non-inhibitory concentrations, 4CMB and BC both induced small, but dose-related increases in SCE. The dose-response curves gave a highly significant correlation for 4CMB (r = 0.996, P less than 0.001) and a significant correlation for BC (r = 0.757, P less than 0.05) which reflects the relative activities of these substances in bacterial mutation tests.

Benzyl Compounds↗