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Biomedical subjects

P C Cavadas

Publications and source records attributed to P C Cavadas.

34 records · Page 2Linked to original sources
PubMed1996

In vivo vascular freezing in clinical microvascular transfer.

Free flap transfer to the lower limb in chronic post-traumatic conditions is known to have a higher complication rate, with flap loss in up to 10% of cases, due mainly to the recipient vessels (Godina: Plast Reconstruct Surg 78:285-291, 1986]). The dissection of these vessels often leads to refractory spasm, due to the so-called perivascular post-traumatic disease (PVPTD) (Khouri [Clin Plast Surg 19:773-785, 1992]). A case is presented of the use of a fairly new spasmolytic maneuver, i.e., in vivo vascular freezing, in a patient who developed intractable spasm of the recipient artery.

Adult↗
PubMed1996

Experimental free tissue transfer over perivascular-injured vessels: effect of in vivo freezing.

Vascular spasm of recipient vessels can increase failure rates in free tissue transfer, especially in post-traumatic perivascular-injured vessels. To investigate the effect of freezing-induced spasmolysis of recipient vessels, an experimental model of perivascular injury was developed in the rat through previous dissection of the femoral artery and epigastric vein (6 weeks before). The contralateral epigastric flap was free-transferred to healthy recipient vessels in group I, to the previously dissected vessels in group II, and to frozen-dilated perivascular-injured vessels in group III. The injured artery showed the same degree of spasm as normal arteries, while the vein showed greater spasm. Ethyl chloride reverted spasm in the injured artery and vein to the same degree as in normal vessels. Flap viability rates were 73.3% in group I, 60% in group II, and 66.7% in group III. The differences were not statistically significant. In conclusion, although further research is needed to improve the experimental model, in vivo freezing with ethyl chloride does not seem to impair free flap viability when used to treat spasm in recipient vessels.

Anastomosis, Surgical↗
PubMed1996

Primary intracranial malignant tumour mistaken for a postburn scalp Marjolin's ulcer.

This report presents an apparent squamous cell carcinoma over a burn scar in the scalp (Marjolin's ulcer) that was resected and soft tissue expanders inserted in the hair-bearing scalp. In the postoperative period the patient developed neurological impairment with a CT scan showing a parasagittal brain tumour infiltrating the skin. The tumour was resected and the resultant skin and cranial defect were covered with an expanded scalp flap. Histological examination showed malignant angioblastic meningioma. The tumour recurred aggressively, leading to the death of the patient. The case is considered very unusual, as a brain tumour does not seem to be a reasonable suspect in the differential diagnosis of a chronic ulcer over a burn-induced scalp scar.

Adult↗
PubMed1996

Prefabrication of a free flap for tracheal reconstruction: an experimental study. Preliminary report.

The development of a prefabricated free flap that could have potential for tracheal reconstruction has been investigated in the goat model. Through a staged procedure, a composite cutaneous-chondromucosal premolded, prevascularized flap was obtained by prefabrication techniques. The procedure comprised three surgical stages. In the first stage, on day 0, the cartilaginous frame-work was constructed, along with the vascular pedicle (implantation of an arteriovenous fistula as a vascular carrier). In the second stage, on day 50, the inner surface of the neotrachea was lined with nasal mucosa. In the third stage, on day 60, the flap was elevated and free transferred to reconstruct a 15-cm circumferential defect in the cervical trachea. Ten animals were operated on, and the results were one infection, three early deaths, one free-flap failure with early tracheal stenosis, and five long-term survivors without significant stenosis. The structure of the neotracheal flap closely resembled that of the native trachea: internal respiratory epithelial lining, cartilage rings, and fibrovascular tissue. Fiberoptic bronchoscopy was done to all the animals at 10 and 60 days, revealing no significant stenosis in the long-term survivors.

Animals↗
PubMed1994

Prefabrication of a vascularized nerve graft by vessel implantation: preliminary report of an experimental model.

Regeneration through vascularized nerve grafts (VNG) seems to be better than nonvascularized nerve grafts (NVNG), especially in hostile beds. We report on an experimental technique of prefabrication of VNG by direct vessel implantation. An arteriovenous fistula was created in the groin region with autologous vein grafts in the Wistar rat model, and implanted into the sciatic nerve. Five weeks later the sciatic VNG was elevated on the prefabricated pedicle. The flap was free-transferred orthotopically over a silicone sheet to impede plasmatic imbibition. Flap viability at 3 days was complete. India ink injection of the AV fistula resulted in capillary ink filling within the nerve and surrounding tissues. Histologic sections of the flap were examined, revealing its neovascularity. In an ongoing study, the regeneration through this prefabricated VNG is being compared to native VNG.

Abdominal Muscles↗