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Biomedical subjects

P C Bhattacharyya

Publications and source records attributed to P C Bhattacharyya.

9 recordsLinked to original sources
PubMed2006

Emergency in malaria.

Malaria is still the most prevalent and devastating parasitic disease worldwide. In recent years drug resistance Plasmodium falciparum malaria has returned to most of the tropical countries of the globe with a vengeance. Due to various atypical manifestations the diagnosis has become confusing and hence the treatment delayed leading to various complications and increased mortality and morbidity. Patient presents with features of severe complicated malaria with multiorgan involvement in the form of malarial crisis needs emergency management in ICU. All fever cases with possible malaria should be investigated and to be treated with intravenous quinine/artimisinine pending confirmation of diagnosis. Any emergency situation that develops during treatment should be treated aggressively as medical emergency.

Adult↗
PubMed2005

A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India.

BACKGROUND: Azithromycin has demonstrated in vitro and in vivo activity against Plasmodium falciparum, but small treatment studies have given mixed results. METHODS: Participants with fever and with both a blood smear and a rapid diagnostic test positive for falciparum malaria were randomly assigned to groups that were treated with either azithromycin or chloroquine or to matched groups receiving a placebo. After an interim analysis, open-label combination therapy with both drugs was initiated. RESULTS: At day 28, 5 (33%) of 15 participants in the azithromycin-treated group had remained free of fever, compared with 4 (27%) of 15 in the chloroquine-treated group. All subsequently enrolled participants then received combination therapy with azithromycin and chloroquine. In 61 (97%) of 67 participants, resolution of fever and parasitemia had occurred by day 7, and, through day 28, no clinical or parasitologic relapse had occurred in them. CONCLUSIONS: Resolution of parasitemia was inadequate with monotherapy with either azithromycin or chloroquine, but combination therapy provided substantially improved clinical and parasitologic outcomes. The combination of azithromycin and chloroquine may be an effective alternative treatment for falciparum malaria and deserves further study.

Adolescent↗
PubMed2003

Transmission of malaria and its control in the northeastern region of India.

Let alone the eradication, malaria control itself has amounted to be a challenge, and is detrimental to the all round development of the northeastern region of India. Focal outbreaks are frequent taking heavy tool on human lives. Plasmodium falciparum is the predominant parasite species and is solely responsible for increased morbidity and mortality. The region contributes bulk of P. falciparum cases for the rest of India, and its proportions are increasing. Efficient vectors like Anopheles minimus, Anopheles fluviatilis and Anopheles dirus persistently support transmission of malaria. The present review gives a comprehensive account of the factors responsible for transmission of the disease with focus on vector bionomics, its prevention and control.

Animals↗
PubMed2003

Primary orbital lymphoma.

Primary orbital lymphoma is a rare condition involving primarily the lacrimal glands. We present the second Indian case of right-sided primary orbital lymphoma in an elderly male who presented with the typical features and showed a good response to chemotherapy.

Diagnosis, Differential↗
PubMed1993

Clinical evaluation of halofantrine in acute malaria.

Fifty patients suffering from acute malaria were treated with 'Halofantrine Hydrochloride'. They were observed for 4 weeks. Clinical, haematological and biochemical parameters were assessed for evaluation of halofantrine in acute malaria, with special reference to its effectiveness, tolerability and side effects.

Acute Disease↗
PubMed1993

Ramsay Hunt syndrome with aseptic meningitis.

A case of Ramsay Hunt Syndrome with characteristic vesicles on the lateral aspect of the left pinna, evidence of infranuclear palsy of the left 7th cranial nerve, associated with same sided loss of taste sensation in the presulcal area of the tongue and perceptive deafness without vestibular disturbances is reported here. The patient had evidence of aseptic meningitis.

Adult↗
PubMed1985

Behr disease.

Explore the source record for details and available documents.

Adolescent↗