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PubMed1986

Relationship between the solubility parameter and the binding of drugs by plasma proteins.

An equation, based on regular solution theory, was used to relate the solubility parameter to the binding of drugs by plasma proteins. The equation was tested on a homologous series and a good correlation was found. Sulfonamides showed maximum binding when their solubility parameters were similar to the solubility parameters of the amino acids situated in a sequence with one tryptophan residue. This observation supports the assumption that this sequence is the primary binding site for the sulfonamides. Binding peaks were also found at solubility parameters in other drug series corresponding to the solubility parameters of human serum albumin (HSA) or bovine serum albumin (BSA) amino acids. It is suggested that the solubility parameter could be used to predict the binding of drugs to plasma proteins.

Amino Acids↗

PubMedDate not supplied

[Epidemiologic profile of induced abortion].

OBJECTIVE: To identify sociodemographic characteristics associated with induced abortion of the first pregnancy and quantify the strength of association between them. MATERIAL AND METHODS: Data were gathered from a survey conducted in the district of Diez de Octubre, Havana, Cuba throughout 1991 and the beginning of 1992. The study population was divided into two comparable groups: one group of women whose first pregnancy terminated in induced abortion and a second group of women whose pregnancy terminated in childbirth. For the variables with statistically significant differences, both the crude and adjusted odds ratio were obtained for the one potentially confounding factor:age. Multivariate logistic regression analysis was employed in the final stage. RESULTS: The sociodemographic characteristic identified as risk factor for induced abortion during the first pregnancy is being younger than 24 years of age, a risk which increased with women who were less than 20 years old, whether single or in union. CONCLUSIONS: Recurrence risk of induced abortion during the first pregnancy is higher in younger women who have not achieved their professional, working or marrying expectations. This situation seem to be incompatible with maternity in the studied group.

Abortion, Induced↗