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Biomedical subjects

P Buri

Publications and source records attributed to P Buri.

At least 37 records · Page 2Linked to original sources
PubMed1989

[The transnasal route of drug administration. Aspects of nasal anatomy and physiology].

The use of transnasal administration of drugs has gained interest with the synthesis of new polypeptidic biologically active substances. Since few years an increasing number of therapeutical hormones delivered through the nose are now available to treat disorders that only used to require parenteral injections to be effective. In its first part the present review describes the anatomy and physiology of the nose in order to gain insight in this site of delivery. The second part deals more specifically with models used to study transnasal absorption and describes parameters that modify drug absorption in relation with the model chosen.

Administration, Intranasal↗
PubMed1987

Determination of pilocarpine by HPLC in presence of isopilocarpine a pH-sensitive polymer in ophthalmic dispersions.

Quantification of pilocarpine in the presence of the epimer isopilocarpine in polymeric dispersions is reported. The method describes a technique using reversed-phase HPLC and UV detection of pilocarpine in the presence of a pH-sensitive polymer. As this method does not require prior sample preparation it will be of special interest for process control and development.

Journal Article↗
PubMed1983

Mechanisms of potassium chloride release from compressed, hydrophilic, polymeric matrices: effect of entrapped air.

The release of potassium chloride from hydroxypropyl methylcellulose matrices was investigated for tablets prepared with several different compression forces. It was determined that the release kinetics for these systems deviates significantly from the classical t1/2 dependence. This behavior was attributed to air entrapped in the matrix during preparation. Removal of the air prior to release restored the traditional t1/2 behavior.

Air↗
PubMed1983

[Not Available].

The main purpose of this presentation is to define the different situations in which dissolution tests are used. The criteria for choosing a method and the establishment of the experimental procedure depend on the research goal. Information concerning the dissolution medium (surfactants, enzymes, volume, de-aeration) confirms, disproves, or completes the classical recommendations.

English Abstract↗
PubMed1981

Comparative in vitro evaluation of six commercial vincamine prolonged-release dosage forms.

This study consisted of a comparison of the release rates of six commercial brands of prolonged-release vincamine. The pH of the dissolution medium was found to be highly significant. Due to the low solubility of vincamine in media close to the neutral point, all of the preparations tested, with the exception of one, showed highly variable release curves under the three pH conditions chosen.

Delayed-Action Preparations↗