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Biomedical subjects

P Burger

Publications and source records attributed to P Burger.

At least 55 records · Page 3Linked to original sources
PubMed1986

Parkinson plus syndrome: diagnosis using high field MR imaging of brain iron.

The distribution of iron in the brain was analyzed using high field strength (1.5 T) magnetic resonance (MR) imaging in 14 healthy control individuals and six patients with Parkinson plus syndromes (multisystem atrophy and progressive supranuclear palsy) who were unresponsive to antiparkinsonian therapy. The normal topographic distribution of iron in the brain as indicated by high field MR images coincided precisely with the distribution of iron in the brain as determined by Perls staining for ferric iron. In Parkinson plus syndromes, there were abnormally increased concentrations of iron (decreased T2 relaxation times) in the putamen, and less prominent increases in the caudate nucleus and lateral pars compacta of the substantia nigra. In high field strength MR images of normal patients, the decreased signal intensity in the globus pallidus is more prominent than that of the putamen. In MR images of patients with Parkinson plus syndromes, the decreased signal intensity of the putamen is more prominent than that of the globus pallidus.

Adult↗
PubMed1986

MRI of brain iron.

A prominently decreased signal intensity in the globus pallidum, reticular substantia nigra, red nucleus, and dentate nucleus was routinely noted in 150 consecutive individuals on T2-weighted images (SE 2000/100) using a high field strength (1.5 T)MR system. This MR finding correlated closely with the decreased estimated T2 relaxation times and the sites of preferential accumulation of ferric iron using the Perls staining method on normal postmortem brains. The decreased signal intensity on T2-weighted images thus provides an accurate in vivo map of the normal distribution of brain iron. Perls stain and MR studies in normal brain also confirm an intermediate level of iron distribution in the striatum, and still lower levels in the cerebral gray and white matter. In the white matter, iron concentration is (a) absent in the most posterior portion of the internal capsule and optic radiations, (b) higher in the frontal than occipital regions, and (c) prominent in the subcortical "U" fibers, particularly in the temporal lobe. There is no iron in the brain at birth; it increases progressively with aging. Knowledge of the distribution of brain iron should assist in elucidating normal anatomic structures and in understanding neurodegenerative, demyelinating, and cerebrovascular disorders.

Adolescent↗
PubMed1986

Production and characterization of antibodies to rat pancreatic acinar cells.

The contribution of immunologic noxae to the damage of the cells and the induction of autodigestion in the course of acute pancreatitis in rats should be regarded. The isolation of intact acinar cells from rat pancreas offers a new approach to a more specific antiserum being directed against antigens at the outside of the cell membrane. Proof of circulating antibodies was performed using the indirect immunofluorescence reaction method (IFAR). A defined membrane fluorescence was observed at the surface of the acinar cells in vitro and a fluorescence at the septa of lobules marking the borders of acini in vivo.

Acute Disease↗
PubMed1986

[Therapy of pediatric anorectal prolapse].

No generally valid and accepted views, applicable to all severities, have so far existed regarding aetiopathogenesis and therapeutic strategies for surgical approach to anorectal prolapse in childhood. More ground has been assumed in recent years by sclerosing therapy. The injections therapy has proved to be highly suitable for severity stages One and Two and for Type I according to Reifferscheid and Altemeier. It should be used before more invasive surgical interventions are decided. This conclusion has been drawn by the authors of this paper from their own therapeutic results obtained from 37 cases of anorectal prolapse in childhood, with therapeutic sclerosing being used in 23 instances.

Child, Preschool↗
PubMed1985

[Determination of the blood pressure index with Doppler sonography--a method for the ambulatory control of late results following vascular reconstruction].

Due to arterial obstructive disease of the lower extremity of aortoiliacal type the p.o. late results (3-9 years) after implantation of bifurcation prostheses are controlled. The establishment of a blood pressure index with the help of the Doppler sonography is in this case in supplementing the clinical findings after Fontaine a valuable method for objectivation in the ambulatory sector. The result of 88% of good and very good p.o. arterial blood supply of the extremities of the patients examined is to be regarded as satisfying.

Aneurysm↗
PubMed1985

[Hemorrhagic complications following vascular reconstructions in arterial occlusive disease of the lower extremity].

In comparison with the results of international literature the authors present their experiences gained from 515 arterial reconstructions for chronic arterial vascular occlusion of lower limb with respect to early and late hemorrhage. In this connection hemorrhage following infections of angioplasty using artificial material is of special significance. Despite of its rare occurrence the aorto-enteric fistula should also be known.

Aorta, Abdominal↗
PubMed1981

[Diagnosis of brain abscesses by angiography and nuclear medicine methods].

In most cases, abscesses are formed otogenically or rhinogenically. The clinical symptoms may be uncharacteristic. The diagnosis is made by employing nuclear-medical and angiographic procedures. In 40 patients suspected of having a cerebral abscess, transfemoral cerebral angiography and in 14 cases gammaencephalography or cerebral scintigraphy was carried out. Angiographically, cerebral abscesses mostly appear as avascular growths while nuclear-medical or localised increase in the activity concentration suggests a pathological finding. The symptoms are uncharacteristic and can only be attributed to an abscess process in connection with clinical and paraclinical findings.

Adolescent↗
PubMed1977

Neuropathology of tissues from patients treated by the Brain Tumor Study Group.

The histopathologic diagnoses in 718 brain tumor patients entered in the Brain Tumor Study Group were reviewed, as well as those for 53 of these patients who were reviewed, as well as those for 53 of these patients who were autopsied later. This review documented instances of progression of histologic analplasia. Of particular interest in the autopsied cases were several instances of extensive necrosis in white matter distant from persisting glioma following chemotherapy and radiotherapy. This observation suggested the presence of a structural and/or metabolic alteration in the diseased hemisphere that perhaps makes it more susceptible to further alterations secondary to the adjunctive therapy.

Adult↗