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Biomedical subjects

P Burckhardt

Publications and source records attributed to P Burckhardt.

At least 163 records · Page 9Linked to original sources
PubMed1981

[Combined treatment of Paget's disease of bone with calcitonin and the diphosphonate EHDP].

To avoid the inhibitory effect of EHDP on bone mineralization, a variety of diphosphonates (Cl2MDP, APD) and a combination of EHDP with calcitonin have been used in the treatment of Paget's disease. In the present study, 13 patients received combined treatment with synthetic human calcitonin (HCT 0.5 mg s.c./day, 5--7 days per week) and EHDP (7.5 mg/kg, day, p.o.) for a mean duration of 6.1 months until disappearance of the symptoms. Results were compared with those obtained in a group of 10 patients treated with HCT alone. The clinical and biochemical effects were similar in both groups, although patients on the combined treatment were treated for a shorter period of time (6.1 vs 11.5 months, p less than 0.01). The desired clinical benefit was obtained within the first few months (4.9 +/- 0.9) in the group on the combined treatment, and within 8.7 +/- 2.4 months (p = 0.05) in the HCT group. Although the incidence of biochemical and scintigraphic relapse was higher than reported in the literature, no clinical recurrence has been observed up to 15 months after interruption of the combined treatment. This positive result casts doubt on the relevance of prolonged treatment of Paget's disease with HCT alone or in combination with EHDP, especially in elderly patients.

Adult↗
PubMed1981

[Renal osteodystrophy in patients on maintenance hemodialysis: statistical study of clinical, radiological and biochemical features].

Sixty radiological, clinical and biochemical features were simultaneously recorded in a population of 46 patients on maintenance hemodialysis. Radiological signs of bone reabsorption (hands, acromio-clavicular and sacro-iliac joints) were demonstrated in 65% and were quantified as a radiological index of hyperparathyroidism. The index was correlated with the levels of parathormone and of alkaline phosphatase (p less than 0.01) and with the duration of renal failure (p less than 0.01), and inversely related to bone densitometry (p less than 0.05). Discriminant analysis confirmed the redundant value of parathormone and alkaline phosphatases in predicting bone lesions. Factorial analysis showed the existence of 12 classes of patients statistically close to one another. These results demonstrate the heterogeneity of renal osteodystrophy.

Bone and Bones↗
PubMed1981

Secondary hyperparathyroidism in idiopathic renal hypercalciuria: fact or theory?

Secondary hyperparathyroidism (HP) has been reported to be characteristic of idiopathic hypercalciuria (IHC) of the renal type. Out of the 155 patients with urinary stone disease and a normal plasma calcium level, only 1 had a distinctively increased plasma parathyroid hormone (PTH) level; however, he was found to be hypercalcemic in a second control study. In 33 patients with renal IHC, none had an elevated PTH level measured under normal, low, and high calcium intake. The mean basal PTH level of these patients was identical to that of 86 normal controls; it was significantly lower than that of the patients with primary or secondary HP who had normal PTH levels. During EDTA infusion, seven of eight patients with primary HP and a normal basal PTH level showed PTH responses greater than those observed in six patients with renal IHC, all of the latter responses being in the normal range. Chlorthalidone, given to seven patients with renal IHC during 4 weeks (100 mg/day), did not decrease the PTH levels. Measurement of nephrogenous cAMP performed in only a few patients revealed a slightly increased value in one of them who had an exceptionally severe hypercalciuria. Beside this latter result, no evidence for secondary HP could be found. Although secondary HP is tempting pathophysiological explanation for many characteristics of renal IHC, it seems to be quite rare.

Adult↗
PubMed1980

[Double suprasellar and pineal germinoma with potomania].

A case is reported of suprasellar and pineal germinoma in a 16-year-old male initially presenting with potomania without diabetes insipidus. The role of stimulation of the hypothalamus in producing pathological thirst is discussed.

Adolescent↗
PubMed1980

Treatment of hirsutism, acne and alopecia with cyproterone acetate.

Cyproterone acetate, combined with ethinyl estradiol, was administered to 60 women (mean age: 25 years) suffering from hirsutism, acne and alopecia for 3--39 months. The rate of success was 94% for acne, 85% for hirsutism and 55% for alopecia. These results are comparable to those already reported. No correlation was found between the degree of the disease or plasma levels of testosterone, androstenedione, respectively urinary 17-cetosteroids, and the effectiveness of the treatment. Side effects were rare and identical in frequency and nature to those encountered during treatment with estrogen-containing contraceptives.

17-Ketosteroids↗
PubMed1980

Parathyroid response to EDTA in hypoparathyroidism and in tetany.

The parathyroid response to an EDTA infusion was measured in 11 patients with hypoparathyroidism and 22 patients with normocalcaemic tetany, and compared to that of normal controls and of 23 patients with primary hyperparathyroidism. Despite comparable basal PTH values, the patients with hypoparathyroidism and the normocalcaemic patients, with tetany following thyroid surgery, responded less than normals to EDTA, while normocalcaemic patients with tetany due to psychogenic hyperventilation responded more than normals. In hypoparathyroidism, mainly three types of results were observed: no response (total hypoparathyroidism), diminished or delayed response (partial hypoparathyroidism), and discrepant results using different antisera in cases of idiopathic hypoparathyroidism, suggesting the secretion of immunologically abnormal PTH. In tetany due to psychogenic hyperventilation, parathyroid hyperreactivity might be explained by repeated stimulation through respiratory alkalosis. Although the EDTA test rarely improved the diagnostic accuracy of basal PTH measurements in primary hyperparathyroidism, it was useful for differentiating between latent hypoparathyroidism and tetany due to psychogenic hyperventilation, both presenting with normal plasma calcium.

Calcium↗
PubMed1978

[Determination of plasma parathyroid hormone in the differential diagnosis of hypercalcemias associated with malignant tumors].

In 44 patients, all suffering from a malignant disease with hypercalcaemia, plasma parathormone was measured by a radioimmunoassay measuring the intact PTH molecule. The results as a function of plasma calcium were compared with those in 38 patients suffering from proven primary hyperparathyroidism and with those in 9 cases of hypercalcaemia of other origin. PTH was indetectable in 14 cases of malignant disease and normal in 25 cases. In 5 patients only could PTH and plasma calcium not be separated from primary hyperparathyroidism. 3 patients had an increased PTH level when plasma calcium was lowered by treatment of the underlying disease. In patients with malignant disease hypercalcaemia is rarely caused by increased secretion of PTH. In these cases either primary hyperparathyroidism or ectopic secretion of PTH may be the cause of hypercalcaemia.

Diagnosis, Differential↗