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P Buchanan

Publications and source records attributed to P Buchanan.

40 records · Page 3Linked to original sources

Crew health status and monitoring summary: the second manned Skylab mission.

We have attempted to show that objective data used to assess crew health comes to the responsible physicians from the laboratories of the experimenters in sporadic and overwhelming amounts, but rarely in the real-time or near real-time frame which is preferred. The crew surgeon generates little hard data by his own efforts. Because of these factors, whenever an over-all clinical assessment of a particular crewman's fitness to continue a mission is an immediate necessity, it must too often be given on what the clinician would consider less than adequate data. Beginning on MD 28, weekly conferences were held with senior NASA management to make a "Go" or "No-Go" recommendation to continue or terminate the mission. In the absence of absolute indications of an unacceptable declining crew health, a clinical judgment was required. To tighten the criteria for decision-making, the authors selected factors that seemed indicative of overall health and plotted them both as real-time and percentage changes from preflight means. Other plots of the most readily available real-time and near real-time data were also developed for this purpose. The major success of this effort was the initiation of a method which indicated interesting and worthwhile possibilities if continued, refined, and computerized for more rapid availability. Correlation of actual post-flight findings with results anticipated from this method was gratifying but not statistically defensible. Whether or not this method would have forewarned of a serious decrement in crewmen's health cannot be known because, in fact, they were healthy and remain healthy.

Adult↗

Dominant inheritance of hemophilia A in three generations of women.

A bleeding diathesis is described which is phenotypically indistinguishable from hemophilia A and which has been transmitted as a dominant trait in three generations of women in a North Carolina kindred. The abnormal phenotype is characterized by clinical mildness and slightly abnormal clotting time, prothrombin consumption, and partial thromboplastin time. Bleeding time, platelet count, clot retraction, tourniquet test, and prothrombin time are normal. Concentration of factors I, II, V, VII, IX, X, and XII are normal, while factor VIII activity is reduced to 2%-5% of control values. De novo synthesis of factor VIII does not occur after transfusion; factor VIII-related antigen is normal; patients' plasmas aggregate platelets normally in the presence of ristocetin, and a typical protein pattern is seen when a chymotryptic digest of cryoprecipitate of the proband is examined by SDS-polyacrylamide gel electrophoresis. Six possible genetic explanations are entertained. Balanced X-autosomal translocation of hemophilia A heterozygotes has been excluded by cytogenetic analysis of metaphase chromosomes. Classes von Willebrand's disease (vWd) is probably excluded on the basis of the laboratory data, and extreme lyonization of hemophilia A heterozygotes on probabilistic grounds. The genetic possibilities which cannot be excluded include a previously unrecognized variant mutation at the vWd locus, a dominant mutation at the hemophilia A locus on the X chromosome, and dominant mutation at a hypothetical fourth locus involved in factor VIII synthesis and control.

Animals↗

Dermatology.

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Education, Nursing, Continuing↗