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Biomedical subjects

P Brugger

Publications and source records attributed to P Brugger.

66 records · Page 4Linked to original sources
PubMed1987

[Effectiveness of alpha-methyldopa in complex ventricular extrasystole by inhibition of central sympathetic activity].

Twelve patients (11 men, 1 woman) suffering from coronary heart disease, with a mean age of 59 +/- 9 years, were examined before and after 2 weeks of treatment with alpha-methyldopa by means of a 24-hour ECG. Statistical evaluation of the 24-hour analysis of ventricular arrhythmias revealed a decrease of the ventricular extrasystoles from 1605 +/- 2088 to 385 +/- 291 (p less than 0.01). A similar result was also found for couplets, which decreased significantly from 25 +/- 46 to 1.0 +/- 1.5 after treatment with alpha-methyldopa. Statistical evaluation of the maximal grade of arrhythmias according to Lown's classification showed a significant improvement in the Lown grades from 4.2 to 3.2 in all patients (p less than 0.001). Ventricular tachycardia, present in 5 of 12 patients, were prevented in all cases by alpha-methyldopa.

Cardiac Complexes, Premature↗
PubMed1986

Plasma concentrations of high-density lipoprotein (HDL)-2 and HDL-3 in myocardial infarction survivors and in control subjects.

The serum concentration of several lipids, including high-density lipoprotein-cholesterol (HDL-C) and the HDL subfractions, HDL-2-C and HDL-3-C, were measured in 44 male and 26 female survivors of myocardial infarction and compared with those of a control group matched for age, sex, and body weight. Serum concentrations of total cholesterol (TC) and low-density lipoprotein (LDL-C) were significantly increased in patients as compared to control individuals. The total HDL-C concentration was lower in patients than in controls. By differential quantitation of HDL subfractions with a new precipitation method using polyethylene glycol, it was found that HDL-3-C was not significantly different between female patients and controls. The reduction of HDL-3-C in male patients was only of borderline significance. HDL-2-C in contrast was highly significantly reduced in both male and female patients. The greatest difference between patients and controls was found in the HDL-2/HDL-3-C ratio. It is therefore concluded that HDL-2-C quantitation is a valuable risk indicator for myocardial infarction yielding a better discrimination of patients from controls than total HDL-C quantitation.

Adult↗
PubMed1986

[Nuclear medical determination of left ventricular diastolic function in coronary heart disease].

In 191 patients with confirmed coronary disease we determined the left ventricular diastolic function with the Nuclear Stethoscope by the aid of the Peak Filling Rate (PFR) and the Time to Peak Filling Rate (TPFR). Moreover we investigated the ejection fraction (EF). 123 patients had already suffered a myocardial infarction, of these 59 an anterior wall infarction and 64 an inferior wall infarction. The remaining 68 patients had a CAD without a history of myocardial infarction. The PFR was 2.20 +/- 0.64 EDV/sec in the 59 patients after anterior wall infarction and 2.64 +/- 0.82 EDV/sec in the 64 patients after inferior wall infarction and 2.83 +/- 0.84 EDV/sec in 68 patients with coronary artery disease without a history of myocardial infarction. The TPFR was 178 +/- 36.7 msec after anterior and 157 +/- 49.2 msec after inferior wall infarction and 156 +/- 47 msec in the patients with CAD without previous infarction. The left ventricular diastolic function (PFR and/or TPFR) was abnormal in 87% after anterior wall infarction and in 81% after inferior wall infarction. In comparison with this the ejection fraction was reduced in 66% in anterior and in 61% after inferior wall infarction at rest. These results indicate that the resting diastolic function appears to be more informative for evaluation of a left ventricular dysfunction than the systolic function at rest.

Adult↗
PubMed1985

[Non-invasive nuclear medical evaluation of left ventricular function in patients with coronary heart disease. Comparative study with the floating catheter].

In this paper there has been analysed the diagnostic value of the parameters of the diastolic function (Peak Filling Rate, PFR and Time to Peak Filling Rate, TPFR) which are not to be covered by invasive methods. To this examination we applied a recently discovered nuclear medical method: we used the Nuclear Stethoscope and with it were able to investigate not only the systolic function (Ejection Fraction) but also the diastolic function (PFR, TPFR). In addition to this we undertook a floating catheter during exercise for the critical examination of the left ventricle. The examined patients consisted of 28 patients, suffering from Coronary Heart Disease, the majority of them after myocardial infarction. In patients suffering from CHD there may be found relations between the nuclear medical parameters of the diastolic function and the pulmonary capillary wedge pressure as far as in all patients who showed a functional disturbance with the aids of invasive methods this could also be proved non-invasively.

Blood Pressure↗
PubMed1985

[Left ventricular diastolic function and ventricular arrhythmias in coronary heart disease].

In 70 patients suffering from coronary heart disease, to a large extent after myocardial infarction, left ventricular diastolic function was examined with a nuclear stethoscope using Peak Filling Rate (PFR) and Time to Peak Filling Rate (TPFR). Ventricular arrhythmias were recorded by 24-hour ECG and the arrhythmias were analyzed according to the Lown classification. The parameters severing the ventricular arrhythmias were correlated with the previously mentioned parameters of diastolic left ventricular function. A correlation was found between PFR and TPFR and the severity of ventricular arrhythmias, whereby the difference in the PFR between Lown classes 0 and III and also between 0 and IVa was statistically significant. For TPFR a statistically significant distribution could be found only between Lown 0 and III.

Adult↗
PubMed1984

[Lipoprotein Lp(a) as a risk factor for heart infarct--a family study].

Lp(a) concentrations, apolipoprotein A-I and B, and various lipid parameters were measured from members of 3 families in which myocardial infarction frequently occurred. No correlation could be found between Lp(a) concentration and other lipoprotein parameters. It has been demonstrated that myocardial infarction and atherosclerotic diseases occur only in patients with Lp(a) concentrations higher than 70 mg/dl. An unfavourable Apo B/Apo A-I relation or LDL/HDL relation, associated with high Lp(a) concentration seems to play a decisive role in the development of atherosclerosis or myocardial infarction. The study suggests that subjects with Lp(a) values higher than 100 mg/dl could suffer from a special form of hyperlipoproteinemia ("Hyper-Lp(a)").

Adolescent↗
PubMed1983

[A new, non-invasive study method for the determination of left-ventricular function in patients with coronary disease].

With the new development of the Nuclear Stethoscope-a microprocessor based cardiac scintillation probe-it is possible to determine the contractile parameters and the diastolic filling measurement of the left ventricle, after the application of Technetium 99m. Due to the high sensitivity and specificity a functional diagnosis of the left ventricle is possible to approximately 90%. The report describes our first attempts to determine the ejection fraction (EF) at rest and during exercise in 24 patients with diagnosed coronary heart disease. Of the 24 patients, 18 (75%) were already found to have abnormal, in that they did not have the expected increase in the EF. The comparison of the results from the non-invasive probe with those of the coronary angiographic findings demonstrate a good correlation Correlation coefficient r = 0.960). The determination of the EF of coronary patients at rest and especially during exercise, from the point of view of rehabilitation, is of great practical relevance, allowing the residual function of the myocardium after infarction and harmful overloading to be better defined.

Adult↗
PubMedDate not supplied

Lateralized direct and indirect semantic priming effects in subjects with paranormal experiences and beliefs.

The present investigation tested the hypothesis that, as an aspect of schizotypal thinking, the formation of paranormal beliefs was related to spreading activation characteristics within semantic networks. From a larger student population (n = 117) prescreened for paranormal belief, 12 strong believers and 12 strong disbelievers (all women) were invited for a lateralized semantic priming task with directly and indirectly related prime-target pairs. Believers showed stronger indirect (but not direct) semantic priming effects than disbelievers after left (but not right) visual field stimulation, indicating faster appreciation of distant semantic relations specifically by the right hemisphere, reportedly specialized in coarse rather than focused semantic processing. These results are discussed in the light of recent findings in schizophrenic patients with thought disorders. They suggest that a disinhibition with semantic networks may underlie the formation of paranormal belief. The potential usefulness of work with healthy subjects for neuropsychiatric research is stressed.

Adult↗
PubMedDate not supplied

[Studies on the differentiation of chondrocytes in connection with poly ADP ribose synthesis].

Cell differentiation and the behaviour of poly-(ADP-ribose)-synthesis after treatment with methoxybenzamide and procaine was examined in chondrocytes of cell cultures from albino rats. In this study an increase in cell differentiation was connected with a higher level of poly(ADP-ribose)-synthesis. On the basis of an increase in poly(ADP-ribose)-synthesis in chondrocytes an improved scheme of treatment of some rheumatic diseases could be developed.

Animals↗
PubMedDate not supplied

[Myositis ossificans progressiva].

The case of a 19-year-old female patient with myositis ossificans progressiva is reported. This disease is a rare hereditary disorder with a dominant autosomal genotype. The patient had typical ossifications of the humeral and dorsal muscles, as well as of those of the left thigh and upper arm, and also an ankylosis of the left hip. There were typical deformations of the cervical vertebrae and of the skeleton of the hands and feet. Laboratory tests showed alkaline phosphatase to be greatly increased. ECG revealed a bifascicular bundle-branch block, and a high-grade restrictive ventilation disorder was shown up by pulmonary function test. When the stability of the genetic material was investigated, DNA synthesis was found to be normal, DNA repair was slightly accelerated, and the sister chromatid exchange rate following stimulation with mitomycin C was higher than in controls.

Adult↗