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Biomedical subjects

P Brodal

Publications and source records attributed to P Brodal.

At least 19 recordsLinked to original sources
PubMed1999

[Practical procedures in Oslo '96].

In connection with the planning of a new problem-based curriculum, it was decided to develop a detailed plan for the learning of practical clinical procedures. The process involved faculty members from all clinical disciplines and students. For each procedure, level of proficiency, learning methods, time of learning, and control routines were defined. Specific lists like those presented here may help to assure high and even quality of procedural skills acquired during medical pre-graduate training. Furthermore, they may be necessary to achieve optimal co-ordination between pre-graduate and postgraduate training. We recommend that other medical schools initiate processes similar to the one described in this article. However, emphasis of procedural-skills learning should not lead to less attention being paid to the learning of the many complex, non-technical skills of medical practice that cannot be adequately described in operational terms.

Clinical Competence↗
PubMed1997

[Medical education in Norway. One common education, four different models].

There are four medical schools in Norway- in Oslo, Bergen, Trondheim and Tromsø. The curriculum at each faculty has undergone many changes during the last decade. The four curricula vary in both content and teaching methods. Two of the faculties base their curricula on problem-based learning and two have chosen other approaches. Terms with clerkships in local hospitals and in the primary health care system exist in each curriculum as periods which the students must spend on research work of their own choice. All faculties set the same standards in practical clinical skills with which the students must be familiar before graduation. We believe that having four different curricular is of benefit to the education of doctors. Only future evaluation and standard national examinations will determine whether there are any measurable differences in the practical and theoretical knowledge among graduates coming from these medical schools.

Curriculum↗
PubMed1997

Corticopontine terminal fibres form small scale clusters and large scale lamellae in the cat.

We investigated whether terminal fibres in the pontine nuclei are arranged in a lamellar pattern like that demonstrated earlier for pontocerebellar neurones. Following tracer injections in visual and parietal cortices and subsequent computer-based 3-D analysis, we found that labelled corticopontine terminal fibres form numerous sharply delimited aggregates of variable shape. Several of the aggregates are cylindroids (diameter 200-300 microns, length 1-3 mm). The aggregates are confined to a lamellar subspace, the position of which depends on the anteroposterior location of the cortical injections. These findings suggest that the cerebroponto-cerebellar system may be organized according to fairly simple, topographical rules. We discuss the implications of our results in relation to the development of corticopontine topographical organization.

Animals↗
PubMed1997

Salient anatomic features of the cortico-ponto-cerebellar pathway.

Recent studies of the primate corticopontine projection show that the neocerebellum--in addition to connections from motor and sensory areas--receives connections from various association areas of the cerebral cortex, some of which are thought to be primarily engaged in cognitive tasks. The quantities of such connections in relation to those from more clearly motor-related parts of the cortex need to be more precisely determined, however. Furthermore, the anatomic data on origin of corticopontine fibers needs to be supplemented with physiological experiments to clarify their functional properties at the single-cell level. For example, nothing is known of the functional role of the large input from the cingulate gyrus, nor is the input from the posterior parietal cortex physiologically characterized. Finally, the scarcity of corticopontine connections from the prefrontal cortex in the monkey (and probably also in man) may not seem readily compatible with a prominent role of the neocerebellum in certain cognitive tasks. We discuss data--in particular from three-dimensional reconstructions--indicating that both corticopontine projects and pontocerebellar neurons are arranged in a lamellar pattern. Corticopontine and pontocerebellar lamellae have similar shapes and orientations but appear to differ in other respects. Corticopontine terminal fields are sharply delimited, apparently without gradual overlap between projections from different sites in the cortex, whereas pontocerebellar lamellae are more fuzzy and exhibit gradual overlap of neuronal populations projecting to different targets. In spite of the sharpness of the corticopontine projection, there may be many opportunities for convergence of inputs from different parts of the cortex. Thus, the wide divergence of corticopontine projections produces many sites of overlap, and extensive interfaces between different terminal fields enabling convergence of inputs onto each neuron. We suggest that the lamellar arrangement of corticopontine terminal fields and of pontocerebellar neurons serve to create diversity of pontocerebellar neuronal properties. Thus, each small part of the cerebellar cortex would receive a specific combination of messages from many different sites in the cerebral cortex. The spatial arrangement of cerebrocerebellar connections have to be understood both in terms of fairly simple large-scale, gradual topographic relationships and an apparently highly complex pattern of divergence and convergence. Developmental studies of corticopontine and of pontocerebellar projections together with three-dimensional reconstructions in adults suggest that the highly complex adult connectional pattern may be created by simple rules operating during development.

Animals↗
PubMed1997

Cat pontocerebellar network: numerical capacity and axonal collateral branching of neurones in the pontine nuclei projecting to individual parafloccular folia.

We have studied the convergence and divergence in the pontocerebellar pathway. Two or three different fluorescent tracers were injected in separate folia of the parafloccular complex. Retrogradely labelled cells were quantitatively recorded. The estimated total number of labelled neurones in the pontine nuclei contralateral to the injection sites was 18000 (median; range 5000-46000; 14 cell populations, six animals). Using stereological principles, the total number of neurones on one side in the pontine nuclei was estimated to be 490000 (mean; n = 6). Thus, approximately 4% of the total number of neurones in the pontine nuclei would project to a single parafloccular folium. Assuming that the highest estimates of labelled cells are the most representative, the proportion would be 9%. Considering that the volume injected makes up a tiny fraction of the total cerebellar cortical volume, these figures reflect an extreme convergence. After injections in adjacent folia we observed 19-27% double labelling. The double labelling frequency dropped steeply with increasing distance between injections. The strong convergence and limited local axonal branching suggest the existence of extensive branching to widely separated cerebellar regions.

Animals↗
PubMed1994

Lamellar organization of pontocerebellar neuronal populations. A multi-tracer and 3-D computer reconstruction study in the cat.

This study deals with the three-dimensional arrangement of populations of pontocerebellar cell bodies projecting to the parafloccular complex. The fluorescent tracers rhodamine B isothiocyanate, fluoro-gold and fast blue were injected in either adjacent or separated cerebellar folia. A set of coordinates (x, y, z) was assigned to each retrogradely labelled cell and the total distribution reconstructed and displayed on a graphics workstation. At a large scale, we found that the majority of the cells of each labelled population (all projecting to the same folium) were confined to a lamella-shaped tissue volume. Each lamella extended from medial to lateral, and accordingly followed the curving of the pontine grey around the corticospinal and corticobulbar fibre tracts. At a smaller scale, i.e. within each lamellar subspace, the neurons belonging to one labelled population were distributed in aggregates of various shapes. To enable further analysis of the shapes of the intralaminar aggregates, we developed a computer program for unfolding of the lamellae, based on cubic B-spline approximation. The flattened reconstructions were three-dimensional polygonal windows, circumscribing the large majority of the labelled cell swarm (usually 70-80% of the total number of labelled cells in one population). The present findings, taken together with previous data on a gradual, rather than disjunctive, shift of pontocerebellar neuronal position in relation to a gradual shift of target region (Bjaalie et al., Anat. Rec.,231, 510-523, 1991), suggest that the cerebropontocerebellar system may be organized according to a set of fairly simple topographic rules.

Animals↗