Biomedical subjects

P Brandner

Publications and source records attributed to P Brandner.

At least 19 recordsLinked to original sources

PubMed2000

The oestrogen receptor (ER) in normal and abnormal uterine tissue.

Glandular epithelium and stroma of the endometrium show typical behavioural patterns in the expression of oestrogen receptors (ERs) due to both endogenous and exogenous hormonal influence. Thus, the ER is increasingly expelled under the influence of oestrogen during the first half of the cycle. Under the influence of progesterone, the ER disappears during the luteal phase and is not even detectable after day 21. During menopause, the atrophic endometrium typically shows very little, if any, ER expression. In cases of oestrogen-induced hyperplasias, the receptor can again be demonstrated. The ER only disappears when nuclear irregularities occur in cases of adenomatous hyperplasia. In cases of invasive carcinoma, a heterogenous picture is seen which closely correlates with the degree of differentiation.

Endometrium↗

PubMed2000

[Room air as the etiology of gas embolism in diagnostic CO2 hysteroscopy].

During a diagnostic CO2-hysteroscopy in general anesthesia, a manifest gas embolism with a resulting drop of the endexpiratory CO2 partial pressure occurred upon insertion of the instrument. By ending the procedure and through appropriate anesthesiological measures, the occurrence was brought under control and the embolism had no clinical consequences. The incidence encouraged us to reconsider the CO2-hysteroscopy examination technique. As a result, we describe an up to now neglected mechanism which may lead to air embolism in gas hysteroscopy: Similar to hysteroscopy with fluid distension, the whole system has to be purged from air by insufflating CO2 prior to examination. If this step is neglected, up to 40 cm3 of room air may be insufflated into the patient, considering a connective tubing of 200 cm length and 0.5 cm lumen. The scientific organisations as well as the endoscopic training centers and the manufacturers of hysteroflators are challenged to deal with this newly described potential cause of complications.

Adult↗

PubMed1999

The etiology, frequency, and prevention of gas embolism during CO(2) hysteroscopy.

STUDY OBJECTIVES: To assess the frequency of clinically apparent and undetected cardiopulmonary emboli during diagnostic CO(2) hysteroscopy, to determine the causes of these events, and to define a risk profile. DESIGN: Retrospective and prospective case study (Canadian Task Force classification II-2). SETTING: Obstetric-gynecologic clinic of an academic teaching hospital. PATIENTS: Five thousand one hundred ninety-three women. INTERVENTION: Diagnostic CO(2) hysteroscopy performed between September 1990 and December 1998. MEASUREMENTS AND MAIN RESULTS: From September 1990 to December 1996, 1 (0.03%) severe but nonfatal embolism occurred in 3932 diagnostic CO(2) hysteroscopies. Undetected emboli were present in 20 patients (0.51%). Starting in January 1997 the gas supply tube (volume 40 ml) was deaerated before the procedures, and no emboli occurred in the next 1261 examinations up to December 1998. The decrease in frequency was statistically significant (p = 0.009). No pathologic flow sounds were found in any of 50 hysteroscopies monitored by Doppler stethoscope. CONCLUSION: A manifest gas embolism is rare in diagnostic CO(2) hysteroscopy. The 10% to 50% frequency of undetected gas emboli cited by other authors could not be confirmed. If the supply tube system that holds room air is purged with CO(2) before the procedure, the already low risk drops to zero or almost zero, confirming the theory that emboli that occur during CO(2) hysteroscopy are caused by room air.

Adult↗

PubMed1995

[The significance of laparoscopically-assisted vaginal hysterectomy--LAVH].

The truly minimal invasive surgeon should always act to the benefit of the patient. Since most of the operative steps of hysterectomy can be performed faster and often better via the vaginal approach than through trocars, minimal invasive surgery does not necessarily mean the employment of endoscopic techniques. Simple vaginal hysterectomy continues to be the least invasive method and 60% of all uteri can be removed this way. If vaginal hysterectomy is not feasible, LAVH should be applied since of all variations of endoscopic hysterectomy. LAVH is the one with the least complications, it is not time-consuming and it is easy to learn. The most effective strategy during the laparoscopic part of LAVH is: As much as necessary--as little as possible. This means, if endoscopic operative steps do not prove to be inevitable during diagnostic laparoscopy, they should be renounced in favour of vaginal hysterectomy (LAVH type I). LAVH type I is the method of choice for about 10% of all uteri. 70% of all uteri can be removed by exclusively vaginal operation if vaginal hysterectomy and LAVH type I are taken together. If operative laparoscopy is unavoidable, is should be limited to those steps which can not be accomplished transvaginally. Another 20% of all uteri can be removed without laparotomy if LAVH type II--LAVH with operative laparoscopy--is employed. If this concept is pursued consequently, only less than 10% of all benign hysterectomies have to be performed via laparotomy.

Adult↗

PubMed1995

[Goals of the Endoscopy Project Group of the German Society of Gynecology and Obstetrics].

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Curriculum↗

PubMed1994

The Influence of Operative Laparoscopy on the General Operative Concept in Gynecology

At Caritas-Klinik St. Theresia, Saarbrucken, Germany, 1663 patients underwent gynecologic surgery between 1990 and 1993. In the same period therapy via laparotomy was replaced stepwise by operative laparoscopy. While operative laparoscopy amounted to 70% (n=316) of all operations in 1990, it was 87% (n=515) in 1993. Additionally, the positive experience with minimally invasive surgery permitted us to enlarge the spectrum of indications for operative laparoscopy considerably, so that extensive adhesiolysis within the entire abdominal cavity (n=78 in 1993), adnexal surgery in pre- and postmenopausal women (n=254 in 1993), and laparoscopic hysterectomy (n=71 in 1993) have become routine today. Morbidity of patients after operative laparoscopy was significantly lower than after laparotomy. Our experiences support the view that operative laparoscopy is not only a benefit to selected subgroups of patients but may be applied successfully to the majority of women requiring gynecologic surgery.

Journal Article↗

PubMed1994

[Tumor cell seeding caused by hysteroscopy?].

154 patients suffering from endometrial carcinoma who underwent CO2-hysteroscopy pretherapeutically, were examined as to whether hysteroscopy lead to tumour cell spread to the peritoneal cavity and worsened the prognosis of the patients. For that purpose, both fallopian tubes of 118 women were investigated thoroughly by histology for intratubarian spread of tumourous cells. Only in one of the 118 patients a single tumour cell complex was detected inside the ampullar part of a fallopian tube. Comparing the investigated patients with data from the literature in terms of five-year survival rates and frequency of relapses, our collective showed the same outcome as those from the literature. These results prove, that the prognosis of endometrial carcinoma is not worsened by CO2-hysteroscopy.

Adenocarcinoma↗

PubMed1994

Use of an implantable catheter system for intraperitoneal chemotherapy in ovarian cancer.

To check the efficiency of intraperitoneal chemotherapy of ovarian carcinomas, 15 patients were treated with instillations of mitoxantrone or cisplatinum. An implantable catheter system was used to access the abdominal cavity. Local therapy proved to be without any effect when large tumor masses were treated. Patients with small tumor residues after surgery did not benefit either, partly because of extraperitoneal progress of the disease. Patients without evidence of disease proved to be stable. Side effects of the therapy were usually mild compared with those of systemic chemotherapy. Access to the peritoneal cavity with the implantable catheter proved to be safe and reliable.

Catheters, Indwelling↗

PubMed1993

[Differential, individualized therapy of uterine myoma].

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Combined Modality Therapy↗

PubMed1991

[Value of vaginal ultrasonography in noninvasive assessment of the endometrium of the postmenopausal uterus].

The endometrial carcinoma shows an increasing incidence and represents today the most frequent malignoma of the female pelvis. Until now all techniques of detection of this carcinoma or its precursors are invasive and thus are not suitable for screening investigations. Vaginosonography, as the first non-invasive diagnostic method, now supplies knowledge about the state of the endometrium. At the Gynaecological Department of the University of Homburg/Saar, West Germany, 221 patients had been preoperatively subjected to vaginosonography before they underwent surgery. Sonographical and histological findings corresponded in atrophic endometrium in 82%, in regular, perimenopausal endometrium in 91%, in endometrial polyps and hyperplasia of the endometrium in 56%, and in endometrial carcinoma in 79%. With regard to the detection of endometrial cancer, a specificity of 96%, a sensitivity of 93%, a positive predictive value of 79% and an accuracy of 96% were established. Thus, according to our experience, vaginosonography represents a valid, non-invasive diagnostical method as a suitable instrument for screening the endometrium.

Adult↗

PubMed1991

[Slit drainage versus Redon drainage in a clinical comparison--initial experiences with a new kind of wound drainage system].

In a prospective, randomised study we compared the clinical properties of the established Redon drain with a new type of drain called "slit drain". Both types of drains were examined regarding the amount of drained fluid, the time elapsing until removal of the drain, the frequency of occlusion of the lumen as well as the patient's pain and the required force at extraction of the drain. The statistical analysis showed both drains to have equal abilities in draining of fluid if they were used under vacuum conditions. If used as nonsuction drains, the new device was able to drain more fluid than the established type of drain (p less than 0.05). Statistically relevant advantages of the slit drain were seen in a lower rate of obstruction of the lumen, a higher amount of drained fluid (as non-suction device) as well as an easier and less painful extraction.

Breast Neoplasms↗

PubMed1989

[Marshall-Marchetti-Krantz operation with fibrin gluing. Results after 2 years].

Since broad experience concerning the stability of fibrin sealing is needed, it has become part of the routine program in orthopaedics and in traumatology. Because of these experiences, we decided to modify the standard Marshall-Marchetti-Krantz-Operation replacing all sutures on both sides of the urethra and the bladder neck by fibrin sealing. So far, 76 patients have been operated using to this new method. All patients had a urinary stress incontinence grade II-III, urodynamically verified and a pronounced urethro-cystocele. To judge the results of the operation the following check-ups were instituted: 1. Urodynamic control, 2. lateral cyst-urethrogram, 3. gynecological examination (anatomical control), 4. subjective, individual evaluation of the patient concerning the involuntary loss of urine. Our study shows that we achieved good surgical and functional results as can be demonstrated both clinically and by urodynamic check-up. The advantage of this method of operation using fibrin sealing is to be seen in the broad lifting up of the anterior vaginal wall without unphysiological fixation and at the same time avoiding all risks of sutures.

Aprotinin↗

PubMed1989

Detrusor and compliance changes of the bladder after radical hysterectomy.

Disturbances of bladder function after radical hysterectomy are caused by the damage done to the pelvic nerves. Reduced radicality in cases of carcinoma cannot be discussed. In a prospective urodynamic study we checked bladder changes in patients with radical hysterectomy and compared them to those with incontinence operations. Shortly after operation compliance and detrusor function are severely reduced. After 6 months compliance is normalized, detrusor is still reduced, yet residual urine normal. The patient has learned to use abdominal pressure, thus providing a functional normality.

Female↗

PubMed1977