[Left catheterization. Experience with 200 examinations].
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Biomedical subjects
Publications and source records attributed to P Bopp.
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A diastolic gradient across the mitral valve is generally indicative of mitral valve stenosis. In the present study, echocardiography was used to demonstrate two less common causes of left ventricular inflow obstruction: one patient had a fibromuscular membrane beneath the valve, the other a large vegetation attached to the posterior leaflet of the mitral valve. Echocardiography proved to be the optimal imaging technique in each case.
The acute hemodynamic effects of intravenous amiodarone (Cordarone injectable; Labaz) were studied during cardiac catheterization in 16 male patients with coronary artery disease (age range, 38-64 years; mean, 53 years). Amiodarone was administered as a bolus at a dosage of 5 mg/kg bodyweight over a 1-min period. Measurements were made 5, 10, and 15 min thereafter. The drug had little effect on heart rate, aortic pressure, cardiac index, and vascular resistances. There were small and nonsignificant increases in left ventricular end-diastolic pressure and end-diastolic volume. The ejection fraction decreased slightly and not significantly. In addition to some increases in pulmonary wedge, pulmonary artery, and right atrial pressures, the significant findings were a 15% decrease in maximal dP/dt and a 12% decrease in left ventricular work. These changes point to a slight negative inotropic effect of amiodarone.
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Six hundred selective percutaneous coronary angiographies have been performed, using the Judkins technique. The procedure was well tolerated even by critically ill patients. Considering the low risk (mortality: 1.7%), the relatively infrequent complications (2.7%) and the value of the information obtained, selective coronary arteriography is a prerequisite to any meaningful surgery.
Aneurysm of the pulmonary artery is an uncommon anomaly which may be very difficult to diagnose without angiography. The present report demonstrates that the echocardiographic diagnosis of a pulmonary artery aneurysm is feasible. Correlation between chest X-ray, echocardiogram, cardiac catheterization, angiography and necropsy is presented. Several echocardiographic features of the pulmonic valve motion in pulmonary hypertension, not previously described, are discussed.
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Open heart surgery was performed in a 5 year-old boy with severe hemophilia A and large ventricular septal defect with pulmonary stenosis. High doses of Factor VIIIC superconcentrates delivered as small transfusion volumes allowed the use of extracorporeal circulation with heparin. Transfusions began 5 hours before surgery and were stopped 21 days later. No adverse reaction was observed. Thus major surgery is possible in severe hemophiliacs provided strict rules for replacement therapy are followed.
Long-term aorto-coronary venous graft patency has been examined in a consecutive series of 47 patients (average: 1.6 graft per patient) after a mean follow-up period of 5 years and 9 months (44-108 months) post surgery. Overall patency rate was 71% (52/73 grafts), with the best results for LAD grafts 85% (27/32). Seventy-seven percent of the patients experienced lasting relief from angina. Significant improvement of LV ejection fraction was observed in cases with patent grafts.