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Biomedical subjects

P Bondil

Publications and source records attributed to P Bondil.

33 records · Page 2Linked to original sources
PubMed1988

[Prolonged drug-induced erection. Treatment and prevention].

The efficiency of intracavernous injection (ICI) of drugs for impotence is unfortunately counteracted by a real morbidity. The main danger lies in the persistence of this artificial erection. This pharmacologically induced prolonged erection (PIPE) appears like a real no-ischemic priapism. The risk of ischemic transformation must orientate the treatment of this frequent iatrogenic priapism. A decompressive puncture is often adequate. When ineffective, ICI of anti-erectogenic drugs will be indicated. But, this new treatment of priapism is not always effective, and most importantly, it can be dangerous, requiring considerable prudence for both indications and technics (risks of cavernous necrosis and of severe hypertensive crisis). The morbidity of this new pharmacological method is the major handicap to its wide use. Prevention now seems possible by carefully selection of indications for ICI and of the choice of both drugs and dosage, especially for high risk PIPE groups (neurologic and psychogenic impotence).

Erectile Dysfunction↗
PubMed1988

[Old theories and present-day hypotheses for the mechanisms of erection].

On the basis of old theories and recent observations, the authors discuss the real nature of the activity of the erectile tissue of the corpora cavernosa and spongiosa. Is erection simply produced by passive injection of spongy tissue? Or is erectile tissue like a real live "sponge" which is capable, on its own, of producing and eliminating erection? If this is the case, where is the intra-tissue motor apparatus located? A new hypothesis is proposed.

Humans↗
PubMed1987

[Intracavernous injections of vasoactive drugs. Contribution to the study of their value in erectile impotence].

The obtention of an artificial erection with a single intracavernous injection (ICI) of vasoactive drugs, has upset our conceptions about erection and the approach for erectile failure. If this pharmacologic stimulation increases the reliability of some erection tests, their diagnosis value is still questioned. The complexity of both erection and vasomotricity pharmacology, make difficult the understanding of the mechanisms of these ICI. Their therapeutic value is reduced to the method by self injections, new treatment for impotence, even if it concerns only few impotent patients. Finally, the experimental feature and the unquestionable morbidity of these ICI, mainly priapism, impede their large diffusion. However, in spite of these doubts, this intracavernous pharmacology is a real progress for erection and its troubles.

Adult↗
PubMed1987

[Intracavernosa injections of drugs in erection disorders. Their clinical value apropos of 100 cases].

Several centers of interest have been stimulated by the true progress represented by the use of intracavernous injections (ICI) for disorders of erection. First, we have become conscious of our uncertainties concerning the physiology of erection. Second, they serve to orientate the etiologic diagnosis and prognosis when positive responses are obtained in cases of impotence. Third, they are of therapeutic interest as auto-injections in impotence with, however, the risk of secondary cavernous fibrosis. Lastly, they represent a new treatment for priapism. However, these ICI procedures are still in the experimental stage, and should be used with some caution because of their potential morbidity and unknown long-term effects.

Erectile Dysfunction↗
PubMed1984

[Treatment of idiopathic retroperitoneal fibrosis: ureterolysis of corticoid therapy?].

Steroid therapy has been used as a treatment for idiopathic retroperitoneal fibrosis for the past ten years and more. In 14 out of a series of 19 patients, this treatment was well-tolerated and successful. It acts quickly. The results of medical treatment compare favorably with those of surgical ureterolysis. In the authors' view, steroid therapy is therefore the treatment of choice for this complaint, and surgical management should be confined to the relatively rare setbacks of medical treatment, and to patients who do not tolerate steroids.

Adrenal Cortex Hormones↗
PubMedDate not supplied

[The combination of oral trazodone-moxisylyte: diagnostic and therapeutic value in impotence. Report of 110 cases].

An oral drug treatment was prescribed systematically for one month in 110 unselected patients suffering from impotence: Tradozone (75 mg/day)+Moxisylite (180 mg/day) daily, or at higher doses if possible, and Trazodone (25 mg/day)+Moxisylite (60 mg/day) one hour before any sexual intercourse. Adverse effects were uncommon (6.3%). Satisfactory sexual activity was restored in 28% of cases and an improvement in spontaneous erections was obtained in 42% of cases. No improvement was observed in 30% of cases. This oral drug test therefore presents 3 advantages: a) it facilitates the diagnosis and treatment of impotence by eliminating moderate forms of psychogenic impotence, b) it reduces both the morbidity and cost of investigation of impotence by reducing the number of tests performed, c) it emphasizes the role of oral treatment in impotence. In conclusion, this oral drug test should be used because of its simplicity, safety and real efficacy. The current objectives of this test are to improve the efficacy of oral treatment as a result of pharmacological progress.

Administration, Oral↗
PubMedDate not supplied

[Parathyroid risk in thyroid surgery. Reality and prevention. 502 bilateral thyroidectomies].

Prospective study of parathyroid risk in a bulk of 502 consecutive bilateral thyroidectomies. Early post-operative hypocalcemia has been documented in 8,8% of the patients, but persisted in only 1,6% one year later. Late parathyroid risk of total thyroidectomy is 3,3% but increases twofold if neck dissection is simultaneously performed. Methods of this study probably misdiagnose a number of mild hypoparathyroidism. Lack of early hyperphosphoremia seems to be an optimizing criteria for aftermath. In Grave's disease, early post-operative hypocalcemia is more common (6,9%) but often subsides (definitive risk: 0,4%). This acceptable morbidity is compared to the data of literature. To prevent post-operative hypoparathyroidism a painstaking dissection of parathyroid blood supply seems more promising and effective than routine autotransplantation of the glands.

Graves Disease↗