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Biomedical subjects

P Bock

Publications and source records attributed to P Bock.

25 records · Page 2Linked to original sources
PubMed1992

Effect of early onset angiotensin converting enzyme inhibition on myocardial capillaries.

We investigated the preventive effects of long-term treatment with the angiotensin converting enzyme inhibitor ramipril on myocardial left ventricular hypertrophy and capillary length density in spontaneously hypertensive rats. Rats were treated in utero and subsequently up to 20 weeks of age with a high dose (1 mg/kg per day) or with a low dose (0.01 mg/kg per day) of ramipril. Animals given a high dose of ramipril remained normotensive, whereas those given a low dose developed hypertension in parallel to vehicle-treated controls. At the end of the treatment period, converting enzyme activity in heart tissue was inhibited dose-dependently in the treated groups. Both groups revealed an increase in myocardial capillary length density together with increased myocardial glycogen and reduced citric acid concentrations. Left ventricular mass was reduced only in high dose- but not in low dose-treated animals. Our results demonstrate that early onset treatment with a converting enzyme inhibitor can induce myocardial capillary proliferation, even at doses too low to antagonize the development of hypertension or left ventricular hypertrophy. We hypothesize that potentiation of kinins is responsible for this effect, probably by augmenting myocardial blood flow, which is a well-known trigger mechanism of angiogenesis in the heart.

Administration, Oral↗
PubMed1990

Inhibition of HIV progression by dithiocarb. German DTC Study Group.

60 patients with HIV-1 infection in Walter Reed stages 2-4 were randomised to treatment with intravenous or oral dithiocarb (diethyldithiocarbamate, DTC) or placebo for 24 weeks in a paired double-blind design. 55 patients were evaluable at the end of the study: no patient who had received DTC but 6 placebo patients had AIDS, a significant difference. Significantly delayed disease progression was observed in the intravenous DTC group compared with its matching placebo. The benefit in the oral DTC group was not statistically significant. During an 18-month follow-up 3 deaths occurred in the original placebo groups, whereas no patient who had initially received DTC died. A significant delay in progression to AIDS was observed in the DTC groups.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Response of bone metastases to medical treatment: definition of evaluation criteria and classification trials].

Bone metastases are very frequent. Some are sensitive to the action of anticancer drugs. However, there is as yet an unsolved methodological problem in the evaluation of response to these drugs. The uniquely radiological UICC criteria are quite insufficient, in as much as they appear with a long delay and sometimes give erroneous results. In this work we give a brief review of biological and clinical knowledge about bone metastases, and we attempt to give an array of the possible evaluation criteria and their respective value. We propose as a working hypothesis a classification of responses taking into account the criteria: the urinary hydroxyproline to urinary creatinine ratio, the serum dosage of bone isoenzyme of alkaline phosphatase and propeptide of type III procollagen (P III NP), and as an essential element, an analysis of all available imaging techniques. A visual study of bone scintillation scans must precede that of radiographs and, when possible, it must be associated to computerized scintillation scanning. When metastasis are located to the pelvis, the vertebral column, or the sternum, a CT scan or better, a nuclear magnetic resonance study (IRM), is indispensable in order to have a direct measure of the tumor extension to soft tissues. Furthermore, in the case of isolated metastases, one of these imaging techniques allows a diagnostic biopsy. Finally an analysis of response at the bone level will always be associated with a measure of their duration and an evaluation of metastases to other sites.

Acid Phosphatase↗
PubMedDate not supplied

[Physical activity after total knee replacement].

AIM: The aim of the study is to find out to what extent patients can do sports after total knee replacement and how patients change their activities compared to the preoperative situation. METHOD: 167 patients, not older than 65 years at time of surgery, who had total knee replacement during the years 1988 to 1998 were asked about their physical activity habits before and after surgery and 112 of them were seen for follow-up examination. RESULTS: 138 (83%) patients correctly answered the questionnaire about their activities. The average age at time of surgery was 55.3 years (21 - 65 yrs), at time of follow-up examination or questioning it was 63.8 years (24 - 78 yrs). The preoperative activity rate was 80.4%. Postoperatively it sank to 75.4%. 99 of the 111 (89.2%) patients returned to some kind of activity after surgery. Walking proved to be the most popular activity (92.8%), followed by swimming (34.2%) and cycling (18.0%). Follow-up examination was done after an average of 74 months (24 - 156) postoperatively and revealed an average Knee Society Knee Score for all patients of 84/70. With a score of 83.4/55.7 the less active group lay under the more active group with a score of 85.2/72.3. CONCLUSION: A tendency towards low impact physical activities could be seen after total knee replacement. Even so, the percentage of patients participating in physical activities was not reduced in a strong way by surgery.

Activities of Daily Living↗