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Biomedical subjects

P Blanquet

Publications and source records attributed to P Blanquet.

At least 19 recordsLinked to original sources
PubMed1985

Visualisation of a thyroglossal duct.

After ablation of an autonomously functioning thyroid nodule resulting from an adenoma, a previously suppressed scintigraphic image of a thyroglossal duct was visualised.

Adenoma↗
PubMed1984

Routine studies of swallowed radionuclide transit in paediatrics: experience with 400 patients.

Scintigraphic studies of swallowed 99m Tc-sulphur colloid mixed with a few millilitres of liquid, performed on 400 paediatric patients of all ages, allowed visualisation of foregut function and measurement of oesophageal transit time and gastric emptying proportions. This non-invasive and physiological procedure requires a standard gamma camera with computing facilities and was performed as an outpatient routine. It proved very effective for the detection of gastro-oesophageal reflux and aspiration of refluxed liquid in patients of all ages but especially in neonates. The relevance of these scintigraphic results to oesophagitis, repeated respiratory problems, cyanotic and apnoeic spells and alternative methods of investigation is described.

Apnea↗
PubMed1984

Biliary atresia and neonatal hepatobiliary scintigraphy.

Hepatobiliary scintigraphy using Tc-99m diethyl IDA was performed on 14 jaundiced neonates. It aided greatly the differential diagnosis between neonatal hepatitis and biliary atresia. Limitations in the interpretation of the results are described, as neonatal hepatitis may be accompanied by biliary excretion ranging from zero to normal. Also both biliary atresia (intra- and extrahepatic) and neonatal hepatitis may show no biliary excretion within 24 hours.

Bile Ducts↗
PubMed1983

Deconvolution analysis of radionuclide angiocardiography curves: problems arising from fragmented bolus injections.

Deconvolution analysis of radionuclide angiocardiography time-activity curves (TAC) in the cases of fragmented bolus injections was studied by using a new deconvolution technique based on the maximum a posteriori estimator. This method was first tested by simulation studies which showed its capability for accurate handling of deconvolution both for single and double peak input functions. These simulations have proved this technique to have advantages over a Fourier transform division method used with a low-pass filter. In patient studies, deconvolution of pulmonary TAC by superior vena caval TAC produced poor results in double peak (fragmented) bolus injections, compared with single peak bolus injections (SPBI). This discrepancy seems to be due to the fact that the postulates of linearity and invariance, on which deconvolution analysis is based, do not hold for the 'cardiopulmonary system' which extends from the superior vena cava to the lung. The differences between the model and the real system appear unimportant for SPBI. However, differences become apparent for fragmented bolus injections. Deconvolution analysis should be avoided with this type of input function in this cardiopulmonary system.

Aged↗
PubMed1983

Pediatric esophageal scintigraphy. Results of 200 studies.

Esophageal transit of a small volume of watery liquid has been observed scintigraphically in 200 studies performed on patients aged between 6 days and 16 years. Qualitative information concerning esophageal morphology and function in the various phases of deglutition, and scintigraphic features of achalasia, stenosis, and other pathologies are described. Measured esophageal transit time and its normal variation, its relevance to the diagnosis of esophagitis, and the monitoring of treatment are discussed. This technique observing distinct deglutitions has proven a useful diagnostic tool. Its advantages and limitations are discussed in comparison with other methods.

Adolescent↗
PubMed1983

In-vivo hypocalcaemic, hypophosphataemic and hyperlipaemic activities in the common peptide sequence of adrenocorticotrophin, melanocyte-stimulating hormone and lipotrophin.

A heptapeptide solution in acetate buffer (pH = 4, 150 micrograms/kg) of the amino acid sequence common to ACTH, alpha- and beta-MSH and lipotrophin, when injected intravenously into rabbits produced an increase in total lipids, cholesterol and free fatty acids after 1 h and a decrease in plasma calcium and phosphate after 2 h. No significant modification in the amount of creatinine, uric acid, urea, total proteins, CO2, Cl-, K+ or Na+ was observed.

Adrenocorticotropic Hormone↗
PubMed1982

[Radioisotopic study of bone growth and maturation. 160 cases].

Increases in blood supply, and certain metabolic and physical processes, are of special significance in epiphyseal growth centers. Such events are evidenced by the uptake of 99mTc methylene diphosphonate (MDP). Bone scans in children and young adults show increased radionuclide uptake in epiphyseal growth plates. Age-related changes in 99mTc MDP epiphyseal uptake can be used for determining a functional bone age. Radiation exposure is within the range of other routine diagnostic procedures. Scanning was done with a gamma scintillation camera, which supplies rapid, high resolution, studies. In the first five years of life, nearly all the main epiphyseal growth plates were visible symmetrically on routine scans. In six cases, growth plates were visible before the corresponding epiphyseal ossification foci became apparent on roentgenograms. Little bones (hands, wrists, feet, and ankles) were not assessed because of the poor resolution of the parallel collimator-camera system. A slow decrease in epiphyseal growth plate activity was demonstrated in subjects over sixteen years of age. In some instances, this decrease occurred only after epiphyseal closure became visible on roentgenograms. Data described here are not usually employed for clinical purposes, except when viability of a growth plate is doubtful. Functional analysis with 99mTc MDP is a useful complement to roentgenologic investigation of skeletal growth and maturation.

Adolescent↗
PubMed1982

Proteoglycan synthesis in chondrocyte cultures from osteoarthrotic and normal human articular cartilage.

Chondrocytes derived by outgrowth from normal and osteoarthrotic human femoral head cartilage were grown in high density cultures for five passages. Cultures were analysed for their sulfated macromolecular components in medium, layer-matrix and intracellular compartments. Two fractions were obtained: typical proteoglycans and glycosaminoglycan-peptides (Mr approx. 60 000) which might result from an enzymatic degradation of proteoglycans. Proteoglycans from normal and osteoarthrotic cultures exhibited similar biochemical properties (size, protein:uronic acid ratio, glycosaminoglycan composition). Slightly less proteoglycans were aggregated with hyaluronic acid in osteoarthrotic than in normal cultures. Three populations of proteoglycan subunit were obtained under dissociative conditions (Sepharose CL-2B) in both normal and osteoarthrotic cultures: proteoglycan 1 (Kav=0.04), proteoglycan 2 (Kav=0.26) which were aggregated with hyaluronic acid in associative conditions, and proteoglycan 4 (Kav=0.48). A fourth population, proteoglycan 3 (Kav=0.33, Sepharose 2B and CL-2B) was intracellular in osteoarthrotic cultures. After a 4 day incubation period, about 60% more proteoglycans were found in osteoarthrotic than in normal cultures (medium+52%, layer-matrix + 44% and 17 times the normal value inside the cells). Proteoglycan distribution kinetics in the three compartments showed a higher net accumulation of proteoglycans in osteoarthrotic-derived cultures.

Carbohydrates↗