Flexible learning options for the degree MMedVet (Chir).
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Animals↗
Biomedical subjects
P Bland-van den Berg
Publications and source records attributed to P Bland-van den Berg.
Serum digoxin concentrations in canine congestive heart failure.
Digoxin was administered to dogs (n = 10) in congestive heart failure, at an oral dosage rate of 0.01 mg kg-1 lean body mass twice daily. Lean body mass was determined by reducing gross mass by the estimated degree of ascites and body fat. The dose was further adjusted for factors such as renal and hepatic function, the bioavailability of different formulations, and the size of the patient. Trough and peak serum digoxin concentrations were determined after 10 days of digitalisation, or when signs of toxicity became apparent. Serum digoxin concentrations in 6 of the 10 dogs were found to be partially or completely in the toxic or subtherapeutic range. This indicates that an oral digoxin dosage rate of 0.01 mg kg-1 lean body mass administered twice daily, even when adjusted appropriately for factors that affect digoxin pharmacokinetics, provides no more than a rough approximation of the precise dose required to provide serum digoxin concentrations within the therapeutic range. The observations also lend support to a recent recommendation that the digoxin dosage rate should be based on body surface area, although even when administered on this basis, serum digoxin concentrations outside of the therapeutic range could be anticipated.
Animals↗
A pulmonary giant cell carcinoma in a dog.
A case of a large cell anaplastic carcinoma of the giant cell type in the lungs of a 5 year-old crossbred male Labrador is discussed. The dog was weak, depressed, febrile and markedly dyspnoeic. An intermittent moist cough and auscultable crackling rales were evident. Radiographic examination was indicative of pneumonia and pulmonic neoplasia. The dog died 36 hours after admission despite antibiotic and supportive therapy. At autopsy, the neoplasm appeared as numerous firm greyish-white nodules of varying size throughout all the lung lobes whilst in the right intermediate and diaphragmatic lobes the neoplasm was completely confluent. The microscopic features included: intra-alveolar composites of cells exhibiting considerable nuclear and cytoplasmic pleomorphism; the presence of numerous giant cells scattered throughout the tumour; the occurrence of tumour emboli within both venous and lymphatic vessels; and, metastatic foci in the bronchial and mediastinal lymph nodes. These features were considered to reflect a high degree of malignancy. Comparative and aetiological aspects of bronchogenic carcinomas in man and the dog are discussed.
Animals↗
Oestrogen-induced bone marrow aplasia in a dog.
A case of oestrogen toxicity in the dog is described. The bone marrow was primarily affected with resultant non-regenerative anaemia, leukocytosis followed by leukopaenia, and thrombocytopaenia. Endometritis, toxaemia and disseminate intravascular coagulation were complicating factors. The case terminated fatally intensive therapy.
Anemia, Aplastic↗
Common canine dermatoses.
Refractory canine skin disorders from a large percentage of the cases referred to the Department of Medicine, Faculty of Veterinary Science, University of Pretoria. Included in these conditions are allergic skin diseases, primary pyoderma, generalised pustular demodicosis, endocrine alopecia, dermatomycosis, seborrhoea, acral pruritic nodule and nasal solar dermatitis. These conditions are discussed with emphasis on aetiology, pathogenesis, diagnosis and treatment. Thirteen colour plates illustrate the classical appearance of the dermatoses described.
Animals↗