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Biomedical subjects

P Biassoni

Publications and source records attributed to P Biassoni.

At least 37 records · Page 2Linked to original sources
PubMed1983

T lymphocyte subpopulations in Graves' disease: relationship with clinical conditions.

T lymphocytes were fractionated according to their receptors for IgG (TG) or IgM (TM) and scored in 37 patients with Graves' disease (17 hyperthyroid and untreated. 10 euthyroid on antithyroid drugs, 10 in long-term remission after radioiodine therapy). TG percentages were very low both in untreated and in drug-treated patients. By contrast, normal TG levels were observed in patients in long-term remission. These data are consistent with the hypothesis of a defective suppressor cell activity in Graves' disease.

Aged↗
PubMed1980

[Methodological problems concerning the assay of sex hormone binding globulin with DEAE-cellulose].

Since 1966 a carrier protein for the sex hormones, testosterone and estradiol, has been identified. Mickelson and Petra measured SHBG concentration by adsorption method in 1974. The SHBG contained in serum is incubated with DHT-3H and adsorbed to a cellulose filter. In this study we have reviewed this method. The method showed good reproducibility with a coefficient of variation of 8,1% for low concentration of SHBG and 11,6% for high concentration. No effects of serum dilution was observed. Normal values, expressed as micrograms DHT bound in 100 ml serum, resulted: females, 0,88 +/- 0,08 (ES); males, 0,58 +/- 0,04; pregnancy, 2,94 +/- 0,4. The mean value for males was significantly lower than the mean value for normal females (P < 0,005); pregnancy had a mean value statistically different from the normal females (P < 0,001).

DEAE-Cellulose↗
PubMed1978

[Unusual clinical aspects of hyperthyroidism. Apathic hyperthryroidism].

The principal data in the literature regarding apathic hyperthyroidism are summarised and commented on 3 personal cases are then reported. The nosography of these forms is discussed and emphasis laid on pathogenetic hypotheses and diagnostic and therapeutic aspects. Diagnosis should be precise and early so as to prevent the extremely serious course which is a characteristic of this rare, but not exceptional variant of hyperthyroidism.

Aged↗
PubMedDate not supplied

Twenty-four hour profile of integrated TSH concentration in puberty.

The 24-h pattern of integrated serum TSH concentrations has been investigated in 12 healthy adult males and 14 pubertal boys by means of continuous blood flow sampling. For every subject the integrated values and the mean concentrations, corresponding to the entire 24 hours, to the daytime (08:00-20:00) and to the nighttime (20:00-08:00) were calculated. A circadian rhythmicity has been shown in boys, as well as in adults. The mean TSH concentrations were significantly higher in boys with respect to adults. The nyctohemeral maximum was mostly recorded in pubertal boys after sleep and in adults before the onset of sleep. Mean and integrated concentrations corresponding to the nighttime period were significantly higher than those corresponding to the daytime in both groups. In conclusion, the 24-h TSH secretion seems different in boys with respect to adults both in the increased concentrations and in the time (generally after the onset of sleep) of the maximum.

Adolescent↗