Biomedical subjects
Publications and source records attributed to P Biagi.
Two distinct constitutional bone diseases, Crouzon's and Pyle's disease, transmitted in autosomal dominant manner trough maternal and paternal lines, were observed joined together in a young patient of 17. The roentgenographic pattern of this never (to our knowledge) before reported associated and the mode of inheritance are presented.
A case of febrile hepatic granulomatosis was examined and the many aetiologies to be considered in the differential diagnosis of the condition evaluated. This is not a separate disease but a specific histological peculiarity of the liver. The case in question was diagnosed as hepatic granulomatosis originating in sarcoidosis. This diagnosis requires, it is though, the presence of characteristic granulomas in the liver biopsy sample but more important in the Kweim reaction or preferably in more specific tissue biopsies (spleen, lymph nodes, mesentery). In the present case the histologically revealed initial cirrhosis may be purely concomitant though certain authorities believe that sarcoidotic hepatic granulomas may develop into cirrhosis.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
The authors describes a case of tertiary hyperparathyroidism (HPTH) in a uremic patient on intermittent dialysis treatment: the term refers to an adenoma with ensuing uncontrolled parathormone (PTH) secretion rate arising on the ground of hyperstimulated hypertrophied parathyroid glands. The syndrome was heralded clinically by bone pain, psychiatric disorder and biochemically by increased levels of calcium and alkaline phosphatase (AP), while parathormone (PTH), did not change from basal very high levels as commonly found in uraemic patients. As hypercalcemia in the hemodialyzed is an infrequent finding the only alternative explanation could have been hypercalcemic secondary HPTH related to hyperplastic autonomous parathyroids. For no clinical and laboratory findings as well as US findings and double scintigraphy (99mTc and 201mTl) may suggest differential diagnosis the patient underwent total parathyroidectomy which actually revealed an adenoma of the left superior parathyroid gland. Bone pain and psychiatric disturbances disappeared and now get well on chronic dialysis treatment and 1.25-OH Vit D3 supplement.