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Biomedical subjects

P Bevan

Publications and source records attributed to P Bevan.

At least 37 records · Page 2Linked to original sources
PubMed1982

Visual sensitivity to two-dimensional spatial phase.

We investigate some limits to phase processing in the human visual system with two-dimensional textured images. Results indicate that, although phase sensitivity increases with contrast and energy components of the image, observers cannot discriminate between images and their 45 degrees phase-quantized versions under brief exposure and lower- (less than or equal to 30%) contrast conditions. These results seem to be frequency independent although modulated by different energy levels at each two-dimensional frequency band. Finally, we have analyzed some past texture-discrimination results that occur under identical amplitude-spectra conditions. Here also phase-quantization differences seem to constitute an adequate explanation of discrimination performance.

Humans↗
PubMed1979

The action of microelectrophoretically applied (3,4-dihydroxy-phenylamino)-2-imidazoline (DPI) on single cortical neurones.

1. The technique of microelectrophoresis was used in order to compare the actions of the imidazoline derivative, (3,4-dihydroxy-phenylamino)-2-imidazoline (DPI), with those of dopamine and phenylephrine on single neurones in the cerebral cortex of the rat anaesthetized with halothane. 2. DPI and phenylephrine were almost exclusively excitatory, whereas dopamine could evoke both excitatory and depressant responses. 3. In the case of excitatory responses, DPI appeared to be more potent than dopamine, and was approximately equipotent with phenylephrine. 4. The dopamine antagonist, haloperidol, could discriminate between excitatory responses to DPI and dopamine: responses to dopamine were abolished, whereas responses to DPI, and to a control agonist, acetylcholine, were unaffected. 5. The alpha-adrenoceptor antagonist, phenoxybenzamine, antagonized equally excitatory responses to DPI and phenylephrine. Responses to acetylcholine were not affected. 6. It is concluded that DPI does not stimulate dopamine receptors on cortical neurones; the excitatory responses of these cells to DPI may be mediated by alpha-adrenoceptors.

Animals↗
PubMed1979

The effect of punishment on free-operant choice behavior in humans.

During Phase I, three female human subjects pressed a button for monetary reinforcement in five variable-interval schedules specifying different frequencies of reinforcement. On alternate days, responding was also punished (by subtracting money) according to a variable-ratio 34 schedule. In the absence of punishment, response rates conformed to Herrnstein's equation for single variable-interval schedules. Punishment suppressed responding at all frequencies of reinforcement. This was reflected in a change in the values of both constants in Herrnstein's equation: the value of the theoretical maximum response-rate parameter was reduced, and the parameter describing the reinforcement frequency corresponding to the half-maximal response rate was elevated. During Phase II, the same five schedules (A) were in operation (without punishment), but in addition, a concurrent variable-interval schedule (B) of standard reinforcement frequency was introduced. On alternate days, responding in Component B was punished according to a variable-ratio 34 schedule. In the absence of punishment, absolute response rates conformed to equations proposed by Herrnstein to describe performance in concurrent schedules; the ratios of the response rates in the two components and the ratios of the times spent in the two components conformed to the Matching Law. When responding in Component B was punished, response rates in Component B were reduced and those in Component A were elevated, these changes being reflected in distortions of the matching relationship.

Journal Article↗
PubMed1979

The effect of signaled reinforcement availability on concurrent performances in humans.

During Phase I, three female human subjects pressed a button for monetary reinforcement in two-component concurrent variable-interval schedules. Five different reinforcement frequencies were used in component A, whereas the reinforcement frequency in component B was held constant. Absolute rates of responding conformed to equations proposed by Herrnstein to describe concurent performances, and the ratios of the response rates and the times spent in the two components conformed to the matching law. During Phase II, the availability of reinforcement in component A was signaled by the illumination of a lamp. This resulted in suppression of response rates in component A and elevation of response rates in component B, these changes being reflected in a distortion of the matching relationship which took the form of a bias in favor of component B.

Journal Article↗
PubMed1978

Comparison of the responses of single cortical neurones to tyramine and noradrenaline: effects of desipramine.

1 The technique of microelectrophoresis was used in order to compare the actions of tyramine and noradrenaline on single neurones in the cerebral cortex of the rat.2 Tyramine could both excite and depress cortical neurones. Each tyramine-sensitive cell was also sensitive to noradrenaline. There was a high correlation between the directions of responses to tyramine and noradrenaline, most cells excited by tyramine being excited by noradrenaline, and most cells depressed by tyramine being depressed by noradrenaline.3 In the case of both excitatory and depressant responses, tyramine appeared to be less potent than noradrenaline.4 Tyramine evoked ;slower' responses than noradrenaline, both the latencies to onset and the recovery times being longer for responses to tyramine than for responses to noradrenaline.5 When the rates of release of tyramine and noradrenaline from micropipettes were measured in vitro, no significant difference could be observed between the transport numbers of the two drugs. Thus the difference in potency between the two drugs, and the difference in the time courses of responses to the two drugs, are presumably of biological origin.6 Desipramine could discriminate between neuronal responses to tyramine and noradrenaline: responses to tyramine were antagonized, while responses to noradrenaline were either potentiated or unaffected. Responses to DL-homocysteic acid were not affected by desipramine.7 The results are consistent with the hypothesis that tyramine is an indirectly acting sympathomimetic amine in the brain, and desipramine acts by blocking the uptake of both tyramine and noradrenaline into presynaptic noradrenergic nerve terminals.

Animals↗
PubMed1978

Effect of variable-interval punishment on the behavior of humans in variable-interval schedules of monetary reinforcement.

One male and three female human subjects pressed a button for monetary reinforcement under a range of variable-interval schedules specifying different frequencies of reinforcement. On alternate days, responding was also punished (by subtraction of money) according to a variable-interval 170-second schedule. In the absence of punishment, the rate of responding was an increasing negatively accelerated function of reinforcement frequency, as predicted by Herrnstein's equation. The effect of the punishment schedule was to suppress responding under lower frequencies of reinforcement; responding under higher reinforcement frequencies was much less affected. This was reflected in an increase in the value of K(H) (the constant expressing the reinforcement frequency corresponding to the half-maximal response rate), whereas there was no significant change in the value of R(max) (the constant expressing the maximum response rate). Previous results had shown that variable-ratio punishment resulted in a change in the values of both constants (Bradshaw, Szabadi, and Bevan, 1977). The results of the present study were consistent with the concept that the suppressive effects of punishment on responding depend on the nature of the punishment schedule.

Journal Article↗
PubMed1978

Relationship between response rate and reinforcement frequency in variable-interval schedules: the effect of the concentration of sucrose reinforcement.

Four rats were exposed to variable-interval schedules specifying a range of different reinforcement frequencies, using sucrose of two different concentrations and distilled water as the reinforcer. With sucrose, the rates of responding of all four rats were increasing negatively accelerated functions of reinforcement frequency, the data conforming closely to Herrnstein's equation; this was also true of the data from three of the four rats when distilled water was used as the reinforcer. The values of both constants in Herrnstein's equation were related to the sucrose concentration: the asymptotic response rate decreased, and the reinforcement frequency corresponding to the half-maximal response rate increased, with decreasing sucrose concentration.

Journal Article↗
PubMed1977

The pharmacology of adrenergic neuronal responses in the cerebral cortex: evidence for excitatory alpha- and inhibitory beta-receptors.

1. The technique of microelectrophoresis was used to compare the actions of a range of adrenoceptor agonists on single cortical neurones in the rat anaesthetized with halothane. 2. Phenylephrine and methoxamine were exclusively excitatory, whereas salbutamol was entirely depressant. Noradrenaline and isoprenaline could evoke both excitatory and depressant responses. Lower doses of isoprenaline usually evoked depressions, whereas higher doses, on the same cell, evoked excitatory responses. 3. The alpha-adrenoceptor blocking agents, phentolamine and phenoxybenzamine, reversibly antagonized excitatory responses to adrenoceptor agonists, without affecting depressant responses to adrenoceptor agonists or excitatory responses to acetylcholine. 4. The beta-adrenoceptor blocking agents, propranolol and sotalol, reversibly antagonized both depressant and excitatory responses to adrenoceptor agonists, without affecting responses to acetylcholine. When the effect of sotalol on excitatory and depressant responses to adrenoceptor agonists was compared on the same cell, the depressant responses could be selectively antagonized, without affecting the excitatory responses. 5. It is concluded that (a) responses of cortical neurones to adrenoceptor agonists are mediated by both alpha- and beta-receptors; (b) these alpha- and beta-receptors give rise to opposite effects: the alpha-receptors being excitatory and the beta-receptors being inhibitory; and (c) responses of many neurones reflect the presence of both types of receptor.

Adrenergic alpha-Agonists↗