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Biomedical subjects

P Bertolani

Publications and source records attributed to P Bertolani.

21 records · Page 2Linked to original sources

[Intestinal flora in children with celiac disease].

The variations of duodeno-jejunal bacterial flora are evaluated. 26 celiac children aged 2 to 7 years were divided in three groups. First group: 8 children in active phase of disease on a free diet; Second group: 10 children kept since one year on a gluten-free diet; Third group: 8 children challenged with gluten for some months. As the same time of the jejunal biopsy, a sample of duodenal juice was obtained for bacteriological examination; for this purpose were used the following culture media: Fluid thioglycollate medium (FTM), Blood-agar, Bile Esculin Azide Agar (BEAA), SF, selective for enterococcus, and MacConkey Agar. The results are: The number of bacterias in the first and third group is significantly higher (p less than 0.001 and p less than 0.05 respectively) than the second group with normal intestinal mucosa. Particular variations in bacteriological species in the three groups are not demonstrated. The excessive growth of bacterias in active phase of celiac disease could worse the absorption of lipids, vitamins, iron, and others substances and it could facilitate the local inflammatory processes in the small intestine.

Celiac Disease↗

[Continuous intraesophageal pH monitoring in the study of gastroesophageal reflux (GER) in children. Influence of age on the considered parameters].

Gastroesophageal reflux is a very common event in children; it is studied using 24-hour intraesophageal pH-monitoring, which has a large sensitivity and specificity, but in the literature is not clear if the age of the children could have influence on the parameters considered in the pH-monitoring. The aim of our study is to assess if the age of our small patients could modify the results of pH-monitoring. During 3-year period from 1991-1993 continuous intraesophageal pH-monitoring of 45 children (29 males and 16 females), divided in three groups on the bases of age, homogeneous for number, sex and clinical symptoms, with pathologic reflux time (> 4% of 24 hours) has been evaluated. In our cases the pathologic total reflux time in 24 hours doesn't seem change with age. It has been noted that under two years of age the pH-monitoring measures are homogeneous with a tendency of reflux longer than children over two years. This older group has more after lunch refluxes; that is the number of total refluxes is larger in older children but the number of refluxes with length higher than five minutes is more in younger. These data are discussed in relation to the anatomical and functional gastroesophageal characteristics of the different age of the child.

Adolescent↗