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Biomedical subjects

P Berner

Publications and source records attributed to P Berner.

At least 55 records · Page 3Linked to original sources
PubMed1979

Classification and bioavailability studies with WE 941 by quantitative pharmaco-EEG and clinical analyses.

Psychoactivity, pharmacodynamic properties and drug tolerance of 2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f]1,2-(4-triazolo)[4,3-a][1,4]diazepine (WE 941), a new triazolodiazepine, were studied in 10 normal subjects utilizing quantitative pharmaco-EEG and clinical evaluation methods. In the double-blind, placebo-controlled trial, the subjects received randomized at weekly intervals oral single doses of 0.1 mg, 0.3 mg and 0.5 mg WE 941, placebo, and 30 mg flurazepam as reference substance. Measurements were obtained before and at the 2nd, 4th, 6th h post drug. EEG power spectral density analysis demonstrated no changes after placebo, while WE 941 and flurazepam induced statistically significant alterations characterized by an increase in beta-activity, a decrease in alpha-activity and increase in average frequency ("anxiolytic pharmaco-EEG profile"). In addition, 0.3 mg and 0.5 mg WE 941 and 30 mg flurazepam produced a significant augmentation of delta-activity indicating hypnotic qualities. Considering spontaneous and placebo-induced alterations, evaluation of the time- and dose-effect relationship indicated that all active substances exerted a tranquilizing effect throughout 8 h, while the hypnotic properties of 0.1 mg WE 941 were minimal (up to the 4th h), those of 0.3 mg WE 941 were moderate (up to 6 h) and those of 0.5 mg WE 941 were marked (up to 8 h). The dosage equipotent to 30 mg flurazepam is 0.3 mg WE 941. Heart rate and blood pressure exhibited no relevant changes, while side effects including fatigue, drowsiness and dizziness were mostly observed after the highest dosage of WE 941.

Adult↗
PubMed1976

Effect of bromazepam on gastric acid secretion related to hypnotically induced anxiety.

The effects of bromazepam (0.1 mg/kg b.w. i.v.) and of placebo on gastric acid secretion related to hypnotically induced anxiety were evaluated in a double blind study, 22 experiments were carried out on 4 healthy volunteers. Drugs were injected after one basal hour. Hypnosis was induced immediately thereafter, and a sequence of anxiety-charged situations out of the subjects past was recalled. After one hour, posthypnotic amnesia was suggested, the subjects awakened and observation continued for another hour. Acid output was measured by means of intragastric titration and a telemetering capsule. During hypnosis and recalling of anxiety in both series, acid output decreased. In the posthypnotic hour there was a significant increase of secretion in the placebo-series, while there was virtually no change in the the bromazepam-series. The pattern of acid output in the placebo-series seems to result from an activation of the sympathetic system under anxiety and a rebound vagal activation in the posthypnotic hour. By contrast, under the sedating effect of bromazepam, no anxiety could be evoked and no rebound vagal activation and thereby no increase of acid secretion resulted.

Adult↗
PubMed1976

[Paranoid syndromes in the involution (author's transl)].

Conditions of outbreak and chronification of paranoid syndromes, including the existence of an "axial syndrome" and behaviour theories are hypothetically summarized. The individual characteristics of patients with the first paranoid symptoms during involution appear to depend mainly on three factors: the theme of the delusion seems to be connected with the age at the onset, in more than half of the male patients exogenous psychoorganic symptoms were observed, and in females however predominantly manic-depressive syndroms could be found.

Adult↗
PubMed1975

[Psychotic acts of suicide (author's transl)].

The suicide rate is higher among those who suffer from a physically based psychosis than among the average population. The proportion of endogenous psychoses in suicides is assessed at about one third, and in attempted suicide about 15 per cent. Of the endogenous psychoses, schizophrenia and depression are the principal diseases causing suicidal actions, of the physically based psychoses, all diseases which cause disturbances of this kind, cerebral vascular sclerosis and epilepsy being particularly frequently represented.

Austria↗
PubMed1975

[Present status of research on delusions].

Regarding the definition of the concept of delusion it is stated that up to now delusions can be diagnosed only with the aid of phenomenological intuition. The decisive criterion is the high subjective certainty in the sense of an elimination of the possibility of chance coincidences without any narrowing of affect. The current hypotheses are presented, concerning the choice of theme, the acute elimination of chance without narrowing of affect, the persistence of certainty and incorrigibility. The relationship between age at the onset of the illness and the choice of the illness and the choice of theme are discussed in the light of my own findings. Reasons emerge to believe that, depending on the respective cultural setting, certain age specific themes can play a role in the formation of the content of delusions. The acute subjective certainty, as well as the incorrigibility are linked with organic or endogenous syndromes.

Age Factors↗