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Biomedical subjects

P Berlit

Publications and source records attributed to P Berlit.

156 records · Page 9Linked to original sources
PubMed1982

Impaired biotin status in anticonvulsant therapy.

In 264 epileptics undergoing long-term therapy with anticonvulsants, significantly reduced plasma biotin levels were found compared with a normal control group: 74% of the epileptics had biotin levels of 250 ng/L or less. In patients undergoing single-drug therapy, the mean plasma biotin levels for those treated with sodium valproate were higher than for those treated with phenytoin, primidone, or carbamazepine. The observed reduction in biotin levels might be a factor influencing the efficacy of these three anticonvulsants.

Anticonvulsants↗
PubMed1982

[Reduction of biotin level as a possible factor in the mode of action of anticonvulsants (author's transl)].

Of 117 patients treated with anticonvulsants reduced plasma biotin levels were found in over 80% of cases. Significant negative correlations with the average daily dose and the total amount of anticonvulsants as well as with the plasma phenytoin level were also evident. It is proposed that the lowering of biotin--which is a co-factor of the carboxylating enzyme system--is an important mechanism in mode of action of anticonvulsants. Reduced biotin levels possibly lead to an accumulation of carbon dioxide or a diminution of aspartate in brain tissue. Low biotin levels may also be the cause of some well known side effects of anticonvulsants such as cerebellar disturbances and dermatitis. In comparison to the other epileptics the patients with cerebellar symptoms showed significantly lowered plasma biotin levels.

Adult↗
PubMed1982

Vitamin status in patients on chronic anticonvulsant therapy.

Vitamin levels in blood were estimated in 146 epileptics, aged 20-40 years. Compared to healthy subjects, no higher risk rates of a vitamin deficiency were found in epileptics for vitamins B1, B12, A, C, E and beta-carotene. alpha EGR was elevated only in epileptic females, alpha EGOT in epileptic males, indicating a higher risk of a vitamin B2 and B6 deficiency in these groups. Markedly reduced levels of folate, 25-hydroxy-cholecalciferol, and biotin were found in the epileptics; folate and biotin levels showed a significant negative correlation with the total amount and the average daily dose of anticonvulsants administered.

Adult↗
PubMed1981

[Electroneurographic findings in cyclist's palsy (author's transl)].

The electromyographic and electroneurographic findings of a patient with cyclist's palsy of both hands are reported. The electrophysiological results show a compression syndrome of the deep palmar motor branch of the ulnar nerve without involvement of the hypothenar branches (Fig. 2a, b). Two more types of cyclist's palsy should be differentiated reviewing the literature: 1. a compression of the ulnar nerve at the wrist a lesion of the superficial branch, and 2. a compression of the deep motor branch including the hypothenar branches. As in the literature described probably exists a further type with an isolated lesion of the superficial branch of the ulnar nerve; but there are no electroneurographic findings reported.

Adult↗
PubMed1981

[Multiple transient brain-infiltrates in allergic meningo-encephalitis. Contribution to the differential diagnosis of CSF-eosinophilia (author's transl)].

The case of a patient with transient multiple brain infiltrates in allergic meningoencephalitis--demonstrated by cranial compute tomography--is reported. The differential diagnosis of CSF-eosinophilia in inflammatory diseases of the brain is discussed, with special reference to the involvement of the central nervous system in parasitic infections and allergic reactions. The possibility of transient eosinophilic brain infiltrates as a cause of neurological symptoms in allergic meningoencephalitis is emphasized.

Adult↗
PubMedDate not supplied

Variable innervation of the intrinsic foot muscles. An electrophysiological study.

We performed motor nerve conduction studies of the peroneal and tibial nerve with simultaneous 2-channel recordings (surface and needle recordings) in order to evaluate the innervation of the extensor digitorum brevis (EDB) and the abductor hallucis (AH) muscle. In 11 of 30 subjects (36.7%) compound muscle action potentials (CMAP's) of the EDB and AH were only elicited by peroneal and tibial nerve stimulation (PNS and TNS), respectively. In 19 subjects (63.3%) CMAP's could be evoked by stimulation of the "wrong" nerve. Co-innervation was only stated if needle recordings could also elicit a CMAP which was the case in 15/30 individuals (50%). A co-innervated EDB was found in 15 subjects (50%) with an even greater CMAP after TNS than PNS in 3 subjects. Co-innervation of the AH occurred in 23.3% (7/30) of the subjects with always low CMAP's (< 1 mV). Co-innervation of the small foot muscles by the "wrong" nerve is common and reaches a relevant degree regarding additional tibial nerve supply of the EDB. A low CMAP after peroneal nerve stimulation may confuse the electromyographer by erroneously suggesting axonal damage of the nerve.

Action Potentials↗