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Biomedical subjects

P Berlit

Publications and source records attributed to P Berlit.

At least 109 records · Page 6Linked to original sources
PubMed1989

General dysplasia of the cerebral arteries with persistent primitive acoustic artery and giant aneurysm.

A case of cerebrovascular systemic dysplasia is presented. The anomalies were: persistent primitive acoustic artery, giant aneurysm of the left internal carotid artery, aneurysm of the basilar artery, and an arteriovenous fistula. A review of the literature shows that the association of multiple malformations of cerebral vessels with a persistent primitive acoustic artery has not previously been described. Impairment of embryonic development is suggested as the origin of the malformations.

Adult↗
PubMed1989

[Isolated abducens paralysis--a retrospective study of 165 patients].

In this retrospective study the case reports of 165 patients suffering from an abducens nerve palsy as the main presenting symptom were evaluated. The sixth nerve palsy was more frequent on the left (52%) than on the right hand side (38%), in 10% there was bilateral involvement. In 49 cases a vascular origin was suspected (29.7%), with diabetes mellitus as the most important risk factor (n = 35). Abducens palsies in inflammatory diseases (n = 32, 19.4%) were seen most often in multiple sclerosis (n = 11), viral meningoencephalitis (n = 5) and accompanying systemic viral infections (n = 5). Postvaccinal paresis was seldom (n = 1). Tumours (n = 18, 10.9%) causing sixth nerve paresis were metastases to the brain (n = 7), meningiomas (n = 3) and glioblastomas (n = 2). Nasopharyngeal carcinomas lead in 4 cases to an involvement of the abducens. Aneurysms causing sixth nerve palsy (n = 7, 4.2%) most frequent being located at the intracavernous region of the internal carotid artery (n = 4). In traumatic abducens paresis (n = 5, 3.1%) pathological findings of neuroradiological examinations are rare. In 48 patients (29.1%) diagnosis remained unclear, especially in young adults between the 20th and 40th year of age. Prognosis of abducens paresis is good in lesions of vascular and unknown origin; in these cases non-steroidal antiphlogistics are of benefit.

Abducens Nerve↗
PubMed1989

Trigeminal neuropathy in pontine hemorrhage.

The case of a 23-year-old patient with trigeminal neuropathy due to a spontaneous lateral tegmental pontine hemorrhage is reported. The differential diagnosis of trigeminal neuropathy is shortly described.

Adult↗
PubMed1988

[Rare causes of the Brown-Séquard syndrome. NMR tomographic findings].

In two patients with the classical form of Brown-Séquard's syndrome magnetic resonance imaging (MRI) revealed circumscribed intramedullary foci in the spinal cord at the level of T 10 and C 5, respectively. In the one patient, viral myelitis had been diagnosed by tests on serum and cerebrospinal fluid; in the other, spinal contusion from the history and the course of the illness. MRI demonstrated complete regression of the foci in both patients.

Adult↗
PubMed1988

[Differential diagnosis of superior orbital fissure syndrome].

Paresis of cranial nerves III, IV, VI and the ophthalmic nerve is termed fissura-orbitalis-superior syndrome. It is caused by affections of the surrounding bones, vascular lesions in the region of the cavernous sinus, tumours of sella and sphenoid bones and diseases of the orbital cavity. Cranial computed tomography (with and without contrast enhancement) is a reliable diagnostic method which may be supported by angiography of NMR in individual cases.

Abducens Nerve↗
PubMed1988

[Polyneuropathy following treatment of chronic hepatitis B with vidarabine].

Two patients with chronic hepatitis B received adenine arabinoside, at a dosage of 1000 mg/d for 8 weeks and 700 mg/d for 12 weeks, respectively. At the end of the treatment period both patients had developed severe sensory irritability in the distal parts of the legs: perception of all sensory modalities was impaired. The disorder persisted over the following three years, although in a milder form. Shortly after the onset of the symptoms sensory nerve conduction velocity in both lower legs was not definitely impaired. But six months later it was clearly reduced to below 40 m/sec in the sural nerve, a finding which has persisted a year later. Three years after the first examination both patients are slightly improved, but conduction velocity is not yet normal. The objectively demonstrated long course and the considerable subjective complaints associated with the polyneuropathy argue for a very therapeutic use of adenine arabinoside.

Adult↗
PubMed1988

The prognosis and long-term course of viral encephalitis.

Of 33 patients with viral encephalitis, four (three women, one man) succumbed to the disease. Of the surviving patients, 23 were followed for a median interval of 4 years after discharge. A considerable residual syndrome could be detected in two cases only. The outcome was determined by identification of causative organism (especially herpes simplex virus), initial consciousness disturbances and pleocytosis in the cerebrospinal fluid. On the other hand, the age of the patients, electroencephalographic findings and a symptomatic epilepsy played no major role. Without confirmed virus findings, immunoglobulins were as effective as the virostatic therapy regimens; with identification of causative organism, combined treatment with acyclovir and immunoglobulins was most effective.

Acyclovir↗
PubMed1988

CT findings in subarachnoidal haemorrhage (SAH). A retrospective study of 138 patients.

In a retrospective study the CT scans of 138 patients with the clinical diagnosis of SAH were reviewed. CT was highly sensitive in detecting blood in the CSF spaces during the 3 days following SAH, with decreasing accuracy correlated to the time interval between SAH and CT examination. Clinical state on admission and CT findings were closely related, as were the localisation of detectable blood and the site of source of bleeding. Whereas blood clots in the basal cisterns, above the convexities, and intracerebrally, as well as the finding of a brain oedema, were significantly correlated to the time of survival, hydrocephalus and ventricular haemorrhage had no bearing on the survival time.

Adolescent↗
PubMed1988

[Syndrome of painful muscle fasciculations. Case report and differential diagnostic review].

The case of a patient with spontaneous painful muscular activity is described. We diagnosed the muscular pain fasciculation syndrome. Biopsy of the sural nerve and electrophysiological examination provided evidence of the neurogenic nature of the disturbance showing a remarkable axonal degeneration. In addition, when immunohistochemical studies were performed, the detection of immunoglobulins and complement components suggested an immunological process in the etiology of the disease. The patient made a good response to carbamazepine therapy. This effect is found in various syndromes of abnormal continuous muscle activity. Clinical, neurophysiological and morphological features of this case are discussed in relation of pathogenesis, possible drug effects and related diseases.

Adult↗
PubMed1988

Effect of long-term treatment with antiepileptic drugs on the vitamin status.

The status of vitamins A, B1, B2, B6, B12, C, D, and E as well as that of beta-carotene, biotin, and folate in the blood of over 500 epileptics was compared with that of a normal population. Male and female epileptics showed a poorer supply of vitamins B2, biotin, folate, and 25-hydroxycholecalciferol; the males, of only vitamin B6, B12, and E, and the women, of only vitamin A. Concentrations of beta-carotene and vitamin E in female epileptics were higher. The evaluation of relations between vitamin concentrations and mean daily dose, total dose of anticonvulsants, and duration of therapy suggested a possible influence of anticonvulsant medication on vitamins B1, B2, B6, C, D, E, beta-carotene, biotin, and folate. Concentrations of B vitamins as well as of folate were distinctly lower in patients under monotherapy with enzyme-inducing drugs than in those under valproate sodium. There was no relationship between bone mineral content and 25-hydroxycholecalciferol levels and between the neurographic parameters and the neurotropic vitamins of the B group, which also had no influence on concentration performance. Patients with poorer results in tests of the function of the central and the peripheral nervous system displayed a tendency towards lower vitamin-C levels. There were indications of potential links between immunological status and vitamin B6 and biotin. Males and females with a poorer supply of vitamin C, as well as males with lower riboflavin levels, showed a tendency towards macrocytic anaemia. Cerebellar disturbances were associated with lower concentrations of folate, of vitamin C or D, and possibly of biotin. The incidence of gingival hyperplasia could be linked to riboflavin, to biotin, and possibly also to vitamin C, D, or folate status.

Adult↗
PubMed1987

Hereditary angioedema and aortitis.

A 28-year-old male with hereditary angioedema died of an extensive stroke. Autopsy revealed cicatricial aortitis with narrowing of the coronary ostia, myocardial infarctions, and a left ventricular mural thrombus. There was neither acute inflammation of the aorta nor systemic vasculitis. A possible association of the aortitis with the hereditary angioedema is discussed.

Adult↗