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Biomedical subjects

P Bec

Publications and source records attributed to P Bec.

At least 55 records · Page 3Linked to original sources
PubMed1983

[Meningoencephalic and chorioretinal manifestations of toxoplasmosis in an immunodeficient patient].

With reference to a case of malignant toxoplasmosis in a patient with angioimmunoblastic lymphadenopathy, the following features are recalled: in compromised hosts, clinical manifestations of malignant toxoplasmosis are highly variable, with neurologic signs and fever being predominant; the occurrence of lesions of the fundus, such as chorioretinitis, is an essential clue to the diagnosis; serologic tests for toxoplasmosis should be performed routinely at each stage of the disease in order to ascertain seroconversion through comparison with baseline results.

Adult↗
PubMed1983

[Effect on pressure after instillation of a drop of depot-pilocarpine. Clinical results of its medium-term action].

A clinical comparison of an emulsion containing a new pilocarpine polymer (Polym) compound to that of a traditional pilocarpine salt solution (Plc) on the intraocular pressure (IOP) has been performed in 40 open-angle patients treated with the long acting pilocarpine-complex for 120 days. The treatment protocol was divided into 3 stages: Stage 1 is a single dose treatment where 12 patients were divided randomly into 2 groups of 6 each. The patients of each group were given 1 drop into each eye: 1 drop every 12 hours for Polym, 1 drop every 6 hours for Plc. The patients were observed for a period of 24 hours. After 24 hours without medication, the treatments were crossed over and nycthemeral graph curves were registered for both groups. Stage 2 is a medium term study were the 12 patients used in Stage 1 were added to another 28 patients. All 40 were then assigned to 1 of 2 treatment groups (2 groups of 20 patients each) according to a table of random numbers. Treatments were administered during one month, then cross-overed again during 4 weeks. Stage 3: finally, every patient could choose his treatment (either Polym or Plc) for the rest of the period (2 months). The clinical study shows that the polymer complex (Polym) produced a prolonged therapeutic effect, this being consistant with a slow release pattern and maintained a more effective around-the-clock control than pilocarpine solution. These results were accomplished by two applications per day as compared to the four necessary applications of Plc, on a half daily pilocarpine dose with Polym. The medium term results confirmed the efficacity noted in the short term survey. Most patients preferred Polym to Plc when they were asked. Throughout the 4 months study period, no adverse side effects were reported. Visual disturbances characteristic of pilocarpine eye-drops were reduced from 3 times a day on pilocarpine salt solution to once a day on pilocarpine polymer complex.

Adult↗
PubMed1983

[Ultrastructural study of the photoreceptors of the human retina during aging].

The ultra-structural study of the photoreceptors in the human retina during the aging process was carried out by comparing two groups of patient: 6 young subjects under 25 years of age, and 6 older subjects over 70. Retinal samples were taken from the posterior pole and treated with the classical techniques of electron microscopy. Our works show that during the aging process, nuclear and cytoplasmic morphological modifications are observed. The observation about nuclear modifications is in full agreement with aging process theories according to which the genome plays an essential part. On the other hand, no modification of the external article could be so far observed. Further works will perhaps allow to discover a decrease of the renewal process of the photoreceptor discs.

Adolescent↗
PubMed1983

[Superior bullous retinal detachment: value of the intravitreous injection of sulfur hexafluoride].

15 cases of superior bullous hemi-retinal detachment were repaired during a 16-month period, with a post-operative follow-up of 3-19 months. Intravitreal injection of 0,75-1,5 cc of pure sulfur hexafluoride (SF 6) was performed in 9 cases. The indications for injection at the end of the procedure were: 1) absence of chorioretinal contact in spite of an indentation in the correct position; 2) fishmouth configuration of the retinal break; 3) presence of radial folds over an indentation parallel to the limbus. Only two out of patients required a second operation, due to the development of proliferative vitreoretinopathy. One case was unsuccessful because of a redetachment secondary to massive periretinal proliferation. No complication was observed with the injection of SF 6. In particular, ocular hypertension was avoided by controlling the amount of gas used, always inferior to 2 cc, and postoperative treatment with acetazolamide and topical timolol. The intraocular injection of SF 6 appears to be useful contribution to the surgical treatment of superior bullous hemi-retinal detachment, allowing effective and durable internal tamponade, while avoiding prolonged bedrest.

Absorption↗
PubMed1982

[Sodium cromoglycate eyewash in allergic conjunctivitis. Multicentric controlled double-blind study. Review of the literature].

A randomized double-blind trial was conducted in 143 out-patients with allergic conjunctivitis (281 eyes). Active sodium cromoglycate collyre was compared with placebo in parallel groups over a four-week period. Highly significant advantage for active drug was demonstrated for subjective and objective symptoms as well as for overall assessment by patients and physicians. Results were compared with international data concerning this well-known anti-allergic compound.

Adult↗
PubMed1982

[Optic neuropathy in acute poisoning with methanol].

The authors report four cases of methanol poisoning, two of which suffering acute bilateral optic neuropathy which secondarily leads to optic atrophy. The report the main clinical features of such a poisoning and the actual basis of its physiopathology and treatment. According to the four cases reported, they underline the importance of early diagnosis and specific treatment.

Adult↗