Search PubMed⌕ Search

Biomedical subjects

P Baum

Publications and source records attributed to P Baum.

At least 37 records · Page 2Linked to original sources
PubMed1984

Cardiovascular effects of intracerebroventricular injection of vasopressin in unanaesthetized normotensive and DOCA-salt hypertensive rats.

The mean arterial pressure (MAP) and heart rate (HR) responses to intracerebroventricular (i.c.v.) administration of arginine vasopressin (AVP) in unanaesthetized normotensive control and DOCA-salt hypertensive rats were studied. Intracerebroventricular administration of AVP (0.25-1000 ng) to control rats produced dose-dependent long-lasting increases in MAP (5-45 mmHg) and HR (35-110 beats/min). Peripheral treatment of rats with an antipressor AVP antagonist had no effect on i.c.v. AVP-induced increases in MAP and HR, whereas the responses were blocked by i.c.v. administration of the antagonist. Peripheral administration of phentolamine and propranolol also completely blocked the changes in MAP and HR. DOCA-salt hypertensive rats showed significantly greater increases in MAP and HR in response to i.c.v. AVP and a tenfold lower threshold for stimulation. The results demonstrate that AVP acting on central neural structures can produce increases in MAP and HR by stimulating sympathetic outflow. Increased sensitivity and responsiveness to i.c.v. AVP in hypertensive rats suggest a potential mechanism of action of AVP in hypertension.

Animals↗
PubMed1978

Identification of tubulin from the yeast Saccharomyces cerevisiae.

A tubulin-like protein was identified in the lower eukaryote Saccharomyces cerevisiae. The following criteria were used: (i) copolymerization of the 35S-labeled yeast protein with porcine brain tubulin; (ii) immunoprecipitation of the 35S-labeled yeast protein with antiflagellar tubulin antibody; (iii) the presence of the yeast protein as a constituent of isolated yeast nuclei; and (iv) splitting of the yeast protein in a gel electrophoretic system containing sodium dodecyl sulfate that resolved the alpha- and beta-tubulin chains from other sources. This protein did not appear to have significant affinity for the plant alkaloid, Colcemid.

Cell Nucleus↗
PubMed1972

Test of a life support system with Hirudo medicinalis in a sounding rocket.

Two Nike-Tomahawk rockets each carrying two Biosondes were launched from Wallops Island, Virginia, the first on 10 December 1970 and the second on 16 December 1970. The primary objective of both flights was to test the Biosonde life support system under a near weightless environment and secondarily to subject the Hirudo medicinalis to the combined stresses of a rocket flight. The duration of the weightless environment was approximately 6.5 minutes. Data obtained during the flight by telemetry was used to ascertain the operation of the system and the movements of the leeches during flight. Based on the information obtained, it has been concluded that the operation of the Biosondes during the flight was similar to that observed in the laboratory. The experiment and equipment are described briefly and the flight results presented.

Air Conditioning↗