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P Bauer

Publications and source records attributed to P Bauer.

At least 127 records · Page 7Linked to original sources
PubMed1993

Force-time characteristics of the rowing stroke and corresponding physiological muscle adaptations.

The force-time characteristics of the rowing stroke was examined in a coxless pair. Sixteen highly trained rowers were evaluated in their usual training positions (stroke or bow). Stroke rowers had higher stroke speed and stroke force in the first part of the stroke than bow rowers. This finding was more prominent during competition speed rowing than during endurance training. Higher blood lactate levels and lower base excess were found at both speeds in stroke rowers. During and incremental ergometer rowing test, lactate performance curves were shifted to the left in the stroke rowers. Analysis of morphometric data in the left deltoid muscle demonstrated higher FT fiber content and lower oxidative fiber capacity and fiber areas in the stroke rowers. The results demonstrate adaptation to years of training in a specific boat position.

Adaptation, Physiological↗
PubMed1993

[Factors prognostic of acute kidney insufficiencies following vascular surgery].

Acute renal failure (ARF) following vascular surgery is still associated with high mortality and morbidity rates. A retrospective study of 33 patients, admitted in ICU for ARF following the surgical treatment of aortic occlusive or aneurysmal diseases, was undertaken to determine the risk factors, clinical settings and prognosis of postoperative renal failure. There were 29 men and 4 women, with a mean age of 63 years and SAPS of 18. The surgical procedure was scheduled in more than 50% of the cases. The mortality rate was extremely high (79%); only 4 out of 33 patients were discharged without sequelae. History and clinical settings had addictive effects for the development of postoperative renal failure. Most patients who had sustained oliguria or who developed septic shock or multiple organ failure were associated with poor prognosis. The conclusion is that the prognosis of acute renal failure after vascular surgery depends more on the occurrence of multiple organ failure than the acute renal failure by itself.

Acute Kidney Injury↗
PubMed1992

Determination of zopiclone in plasma using column liquid chromatography with ultraviolet detection.

A reversed-phase liquid chromatographic method with ultraviolet detection for the determination of zopiclone in plasma is described. It is rapid, sensitive, reproducible and linear over a wide range. The method was used to study plasma zopiclone concentrations in a case of acute intoxication after oral ingestion of 300 mg of the drug. The plasma level was 1600 ng/ml 4.5 h after the dose and the elimination half-life was 3.5 h.

Adult↗
PubMed1992

Transient non-cardiogenic pulmonary edema following massive ingestion of ethylene glycol butyl ether.

A case of acute poisoning with ethylene glycol butyl ether (EGBE) is reported in a chronic alcohol abuser. On admission the 53-year-old patient was comatose with metabolic acidosis, shock, and noncardiogenic pulmonary edema confirmed by haemodynamic study. Following supportive treatment and haemodialysis the outcome was favorable. The relationship between respiratory failure and EGBE is examined.

Alcoholism↗
PubMed1992

Gastrointestinal malignant lymphomas of the mucosa-associated lymphoid tissue: factors relevant to prognosis.

Three hundred seven cases (244 gastric, 63 intestinal) of primary gastrointestinal non-Hodgkin's lymphoma (NHL) in stages EI and EII, according to a modified Ann Arbor system, were examined retrospectively. The histological classification for mucosa-associated lymphoid tissue-derived lymphomas was applied. Gastric NHLs (male-female ratio, 0.97; mean age, 64.5 years) were stage EI in 51% and stage EII in 49% of cases. Histological grade of malignancy was low in 41% and high in 59% of cases; all NHLs were B-cell type. Tumors were radically resected in 87%, and overall 2-, 5-, and 10-year survival rates were 61%, 55%, and 46%, respectively. Early lymphomas (substage EI1) had best prognosis (5- and 10-year survival rates, 90% and 70%, respectively). Intestinal NHLs (male-female ratio, 1.1; mean age, 54.4 years) were stage EI in 30% and stage EII in 70% of cases. Histology was low grade in 21% and high grade in 79%, and all but 11 cases were B-cell type. In 58% of cases, radical tumor resection resulted in overall 2- and 5-year survival rates of 44% and 24%, respectively. Major prognosticators for survival in gastric location were low-grade histology, low depth of infiltration, and low stage and radical resectability of lymphoma; all factors were strictly intercorrelated. In intestinal site, radical tumor resectability was highly significant for survival. Cumulative proportion of relapses after 5 years was higher in intestinal than in gastric sites (44% vs. 22%). In conclusion, primary gastrointestinal tract NHLs may represent an entity with respect to characteristic histological features, focal tumor growth, and potential cure by radical resection. Because of late relapses, clinical follow-up is needed.

Adolescent↗
PubMed1992

Hearing loss from industrial noise, head injury and ear disease. A multivariate analysis on audiometric examinations of 110,647 workers.

From compulsory screening examinations of 260,917 noise-exposed workers standardized audiograms as well as medical and occupational histories of 110,647 workers were selected because of full-time exposure to well-defined noise greater than 85 dB (A) and analyzed by loglinear and multiple linear regression. The most important factors for prediction of pure-tone hearing loss at 4 kHz were found to be age, sex and noise immission level. For predicting speech impairment and handicap the history of ear disease, head injury and tinnitus were more important than noise immission level. Dose-response relationships are given to improve prevention and compensation of hearing loss from combined factors.

Adolescent↗
PubMed1992

[Current treatment of poisoning by ingestion of caustic substances].

Lesions by ingestion of corrosive substances had so far been treated at the time of sequelae. In the seventies several events modified deeply the epidemiology and the early care of these poisonings. At that time household products like highly concentrated basic and acid substances and oxidizing agents were distributed and led to an increase of the number and the severity of these intoxications. In the same time, fiberoptic endoscopy of the digestive tract played a leading part to evaluate the diagnosis and the prognosis of these poisonings at an early stage, and thus, with accurate intensive care and digestive surgery contributed to generate appropriate guidelines, according to the severity. The first step of the treatment is fasting, fluid replacement and analgesic if required. A full examination must be performed, especially in the throat even if there is no strong correlation between early clinical signs and the severity of the lesions; blood samples must be obtained to look for metabolic acidosis, hyperleukocytosis hemolysis and consumption coagulopathy which could be better indicators of the severity. Fiberoptic endoscopy of the upper digestive tract should be performed as soon as the physical and psychological patient's condition is stable; if possible before the twelfth hour and no more late than the twenty-fourth hour. It should determine the lesions: type, range and grade according to Quincy's classification modified by Mongon and Di Constanzo. Survival and healing of "extremely severe" grade intoxication can only be obtained through a surgical intervention within the first hours; a laparotomy will indicate the depth of the lesions, which is not determined by endoscopy, and will consist of Celerier's stripping method and if necessary a gastrectomy, more seldom a cephalic duodeno-pancreatectomy. Only the surgical excision of necrotic tissues can prevent the occurrence of lethal complications like oesophageal or gastric perforations and septic shocks. The analysis of the literature from 1975 up to now gives us information on the methods and the results of these different therapeutic approaches.

Adult↗
PubMed1992

[Current status of poisoning by ingestion of caustics: apropos of a series of 49 cases].

The authors report the history of 49 patients, admitted to an intensive care unit after a caustic or corrosive ingestion. This series follows a similar one, related in 1979. An update is made for early evaluation and management, based on patients classification in three groups: severe cases, moderate cases, mild cases. Clinical and biological data, treatment and outcome for the three groups are related. The frequency and gravity of these poisonings appear to be the same as in the first series, with poor prognosis for extreme emergencies and high risk of oesophageal or gastric stricture for important forms. In this population, 20% of extreme emergencies have favorable outcome with early major surgical procedure.

Adolescent↗
PubMed1992

[Impact noise and hearing. A study from audiometry screening in noisy occupational environments].

The hearing loss of 46,776 subjects exposed to hazardous impact or continuous noise was measured: 11% were exposed to impact noise (10.3% in men, 12.7% in women). Impact noise causes less hearing loss than continuous noise up to a noise emission level (NIL) of 115 dB(A). This result is still compatible with the concept of equivalent continuous A-weighted sound pressure level (LA,eq) and seems to be caused by the protective effect of the stapedius muscle. However, at emission levels higher than 115 dB(A), not covered by ISO 1999 prognosis, impact noise becomes more detrimental. This could be the effect of mechanical damage to the organ of Corti, as observed in animal experiments at sound pressure levels exceeding 114 dB(A). A diminishing protective function of the stapedius muscle could explain the more serious hearing impairment after long exposure to impact noise compared with shorter exposures to an equal dose. Since the hearing loss caused by impact or continuous noise is clearly different in the highest NIL ranges, safety criteria for impact noise should be revised. The NIL defined by Burns and Robinson underestimates the effect of the exposure time for impact noise.

Adolescent↗
PubMed1991

Proximal compared with distal adenocarcinoma of the stomach: differences and consequences. German Gastric Cancer TNM Study Group.

Interest in leading prognostic determinants of proximal gastric adenocarcinoma (PGA) in comparison with distally located adenocarcinoma (DLA) of the stomach led to an analysis of data from 506 patients with PGA and 484 patients with DLA operated on between 1 April 1982 and 31 October 1984 and participating in a multicentre observational study to validate tumour node metastasis (TNM) stage groupings. The proportion of men with PGA was slightly higher than that of men with DLA (69 versus 63 per cent). Men more often had cardia carcinomas than women (14 versus 9 per cent); 74 per cent of these men but only 43 per cent of the women were less than 65 years old. Evaluation of data by a log-linear model indicated a strong partial association (P less than 0.001) between age and site; patients younger than 65 years more often had PGA than older patients. Advanced tumour stage and the intestinal type of carcinoma were more frequently seen in the elderly. More than twice as many patients with PGA in comparison with those with DLA (35 versus 15 per cent) had palliative surgery (moderate association, P less than 0.05). This may have resulted from different stages at different sites; advanced carcinomas (TNM stages IIIb and IV) were more often diagnosed in patients with PGA than in those with DLA (60 versus 38 per cent). Residual tumour left after surgery was associated with deeper infiltration (P less than 0.001). No difference between PGA and DLA groups with respect to histological type of carcinoma was established, but residual tumour was more frequently associated with a diffuse type carcinoma (P less than 0.01). An overall tendency to poorer long-term prognosis in PGA was seen for all TNM stages, with and without residual tumour, except for TNM stage II with residual tumour, even though patients with PGA were younger than those with DLA. These differences in long-term prognosis, however, are based primarily on poorer short-term survival for PGA, particularly for TNM stages Ib and II without residual tumour. A significant risk of surgical management, particularly for early-stage tumours situated in the upper part of the stomach, has therefore been recognized. Surgeons should appreciate the higher surgical mortality rate for patients with PGA when curative treatment requires more risky surgical techniques.

Adenocarcinoma↗
PubMed1991

Multiple testing in clinical trials.

The basic ideas of multiple testing are outlined and the problem of how to control the probability of erroneous decisions is discussed. The main emphasis is on the concept of the multiple level of significance (controlling the experiment, or family error in the strong sense) which can be achieved by applying the principle of closed tests. Various practical situations encountered in multiple testing in clinical trials are considered: more than one end point; more than two treatments, such as comparisons with a single control, comparisons using ordered alternatives, all pairwise comparisons and contrast methods; and more than one trial. Tests based on global statistics, the union intersection principle and other criteria are discussed. The application of the multiple test concept in sequential sampling is investigated. Finally some comments are made on multiple power, multiple confidence intervals and directed decisions.

Analysis of Variance↗
PubMed1991

[Early stomach cancer in comparison with advanced stomach cancer. Results of a prospective study of diagnosis and 5-year survival of 131 patients with early stomach cancer and 795 patients with advanced stomach cancer].

A multicentre prospective observational study with 22 surgical and 14 pathological units in West-Germany gathered data from 1420 patients with gastric cancer between April 1982 and October 1989, 131 patients with early gastric cancer (EGC) and 795 patients with a resectable advanced gastric cancer (AGC) were selected for comparison. Patients with EGC were younger than those with AGC (49% vs 37% younger than 60 years) and symptoms of an ulcer were found twice in comparison to AGC (40.7% vs 23.7%). EGC in comparison to AGC were frequently multifocal (9.2% vs 3.0%) and located in the middle and lower part of the stomach (83.9% vs 56.8%). Five-year-survival rates of mucosa carcinoma was 84% and of submucosal carcinoma 69% (p = 0.0741). WHO-typing of EGC and AGC were identical. But according to Laurén's classification there were more intestinal types with EGC than with AGC (60.3% vs 51.5%) and less diffuse or mixed types with EGC than with AGC (33.6% vs 44.0%). Five-year-survival rates of diffuse and intestinal types of EGC showed no significant difference (p = 0.19). Extended lymph node dissection was done in only one third of EGC and AGC. Five-year-survival rates of 36 EGC patients with and 95 EGC patients without extended lymph node dissection were 85% versus 72% (p = 0.0916). These results are a hint that systematic lymphadenectomy may have a beneficial effect on survival.

Adult↗