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Biomedical subjects

P Bartsch

Publications and source records attributed to P Bartsch.

At least 73 records · Page 4Linked to original sources
PubMed1997

[Preliminary results of a screening programme by mobile units in the province of Liege].

The goal of the mass screening of breast cancer undertaken under the authority of the Province of Liège is to focus the action on rural communities. For this reason, mobile vans equipped with X-Ray dedicated units are used. The main difficulty of this programme is to reach a massive participation of the population. It varies up to now from 45% to 20% in the different visited villages. During the 42 first months of functioning, 16,207 mammographies were carried out in women aged from 40 to 69; 69 cancers were discovered in apparently healthy women plus 10 cases of epithelial hyperplasia with atypias. These first results are quite encouraging. The main task of this continuing programme will be to reach a better participation of the population.

Adult↗
PubMed1996

Event-related gamma band activity during passive and active oddball tasks.

The EEG was recorded during passive listening and active attending to tone pips of an oddball stimulus sequence, and the time course of event-related gamma band activity (30-60 Hz) was compared with event-related potential (ERP) components. In the conventional frequency range (0.1-4.3 Hz) mismatch negativity (MMN) was produced in the passive listening condition. Concurrent with MMN, the power of event-related gamma activity to the deviant stimulus was higher than gamma activity elicited by the preceding standard stimulus. The transition from the N2b to the P3 wave, produced during active attention, was associated with a decrease in gamma band power upon the deviant tone. The results show the differential generation of gamma band power depending on preattentive and attentive stimulus processing.

Acoustic Stimulation↗
PubMed1995

The CRE consensus sequence in the synapsin I gene promoter region confers constitutive activation but no regulation by cAMP in neuroblastoma cells.

Synapsin I is implicated in the modulation of neurotransmitter release and in synaptogenesis and is regulated by phosphorylation. The rat and human synapsin I genes both carry CRE and TRE consensus sequences in their promoter regions. This suggested that protein kinase-mediated signal pathways might also regulate synapsin I activity at the level of gene expression and thus contribute, on a slower time scale, to synaptic plasticity. We have therefore investigated, in neuroblastoma cell lines, the effects of agents that activate protein kinases on synapsin I gene expression. Unexpectedly, treatment with forskolin/IBMX was not found to enhance synapsin I mRNA levels. Rather, it causes a decrease to approximately 50% within 1 day although several CRE-dependent control genes are strongly induced. The calcium ionophore, A23187, lowers synapsin I mRNA to approximately 75%, and the phorbol ester, TPA, is without effect. Transient expression of a CAT fusion gene under the control of the synapsin I promoter region is also inhibited by forskolin/IBMX, as well as by protein kinase A (PKA) overexpression, suggesting that the decrease of synapsin I mRNA in response to forskolin/IBMX is due to the inhibition of transcription. Mutation of the CRE consensus does not affect the response to PKA, but it reduces the constitutive activity of synapsin I promoter constructs down to 30-50%. Nuclease footprinting experiments demonstrate sequence-specific binding proteins from brain, liver and NS20Y cell nuclear extracts to the CRE consensus sequence of the rat synapsin I promoter.

Animals↗
PubMed1990

[Plasma histamine and exercise-induced bronchospasm].

The pathogenesis of bronchospasm of effort is not yet elucidated and it is probable that is determined by multiple factors. In this study we have tested the role of mastocytes in taking as an index of their activation the fluctuation of plasma histamine levels during repeated exercise tests. We will show that asthmatic subjects who develop bronchospasm on effort have a significant rise (times 3) in their level of serum histamine whilst normal subjects don't show much change. Furthermore in a repeated effort test we have observed a strict parallelism between the occurrence of bronchospasm of effort and a rise in plasma histamine levels. These different observations enable us to consider that the activation of mastocytes and the liberation of mediators which follow play an important role in the pathogenesis of bronchospasm of effort.

Adolescent↗
PubMed1989

Some remarks on the axial skeleton in Protopterus (Pisces, Dipnoi).

Based on a comparative morphological study of the axial skeleton in a broader range of "primitive bony fishes" a reevaluation of some characteristic traits of the vertebral column in the African lungfish has been done. The axial skeleton of living dipnoans has to be regarded as reduced from a more complex phylogenetic state and may be neotenic in some respect. The formation of perichordal bony autocentra could be confirmed, at least in one specimen. The well-known invasion of mesenchymal cells into the fibrous sheet of the notochord is interpreted as a rudimentary chordacentric "vertebralization". Also included is an analysis of the peculiar urostyle of lungfishes, its regeneration capacity and its bearing upon the principles of vertebra-formation.

Animals↗
PubMed1988

[Visual evoked potentials and water deprivation of rats during intrahypothalamic application of substance P].

Visually evoked potentials (VEP) were recorded in the visual cortex, the dorsal geniculate nucleus and the lateral hypothalamus of satiated and water-deprived rats with and without additional drinking sounds to strengthen motivation and were compared with those during substance-P-injections. Differences in VEP and corresponding spatial and temporal interrelationships of these areas were found by using the method of coincidence of single VEP. Variations of drinking behaviour, weight loss and motor activity were recorded. The findings are discussed with regard to SP and its function as a "regulid peptide".

Animals↗
PubMed1988

[Motivational dependence of changes in visual evoked potentials in rats during water deprivation].

Visually evoked potentials (VEPs) of the visual cortex, the dorsal geniculate nucleus and the lateral hypothalamus of satiated and water-deprived rats with and without additional drinking sounds to strengthen motivation were recorded. Differences in the motivational state led to changes in VEPs and altered interrelations in space and time between these brain areas, as estimated the method of coincidence analysis of single VEP.

Animals↗
PubMed1987

Quality of life of inoperable non-small cell lung carcinoma. A randomized phase II clinical study comparing radiotherapy alone and combined radio-chemotherapy.

Eighty one patients with inoperable non-small cell lung carcinoma (NSCLC) were entered in a randomized phase II trial comparing split-dose irradiation alone to combined treatment radiotherapy and polychemotherapy (C.A.P. + V.D.S.). The quality of life and the survival of the patients were studied. We have defined three classes of quality of life responses based on the time elapsed before the performance status index drops. A higher quality of life failure rate was observed in the combined treatment group (p non-significant) but the time elapsed before the Karnofsky index drops is longer in the combined treatment group for the quality of life "no change" subgroup (p = 0.15). Survival and quality adjusted survival are similar in both treatment groups. The same conclusion holds for retrospective stratified treatment groups. The results of the study are presented according to the decision tree theory. We conclude that as far as the quality of life is concerned, polychemotherapy combined with the particular split-dose irradiation schedule used is an effective treatment of inoperable NSCLC. Its efficiency is comparable to, but not better than, the same radiotherapy schedule alone taken as a reference baseline.

Aged↗