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Biomedical subjects

P Barreiro Tella

Publications and source records attributed to P Barreiro Tella.

At least 19 recordsLinked to original sources
PubMed1989

[Neurologic effects of alcoholism].

The alcoholism is no hereditary but genetic factors can be involved and racial differences in alcohol susceptibility depend on break down rate of ethanol. The alcohol adaptation and tolerance and physical dependence appearance with symptoms and signs display after abstinence on people suffers with chronic intoxication, it would be related to changes caused by alcohol over molecules of neuronal membranes, especially proteins and receptors. An account is achieved about the various neurologic manifestations related to alcoholism, nutritional in origin or unknown pathogenesis. The results obtained looking over the admission along 1988 in Neurological Service ("La Paz" Hospital) allowed to take into account three groups of alcoholic patients (miscellaneous, abstinence syndrome-encephalopathy-dementia-neuropathy, and stroke). It is analysed the results and it is afforded some conclusions about.

Adult↗
PubMedDate not supplied

[Cerebral arteriopathy with subcortical infarctions and leukoencephalopathy with dominant autosomal inheritance (CADASIL). Clinical and morphological study].

OBJECTIVE: The cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is characterized by the recurrence of subcortical infarcts leading to dementia. It is known the genetic and neuroimaging findings, but there are few studies about its histopathology. Our objective had been to study the pathological findings in this arteriopathy. SUBJECTS AND METHODS: We studied two families spreading over four generations. We performed a detailed clinical history, laboratory investigations, neuroimaging study and genetic analysis. Two brain biopsies and one autopsy were done in patients from the two families. RESULTS: Eight affected members, with autosomal dominant inheritance. Age at onset was between 40 and 50 years. This was characterized clinically by recurrent ischemic attacks, headache and subcortical dementia without vascular risk factors. Histopathological findings showed an arteriopathy characterized by a slightly basophilic small arterial granular degeneration of the medial sheath associated with the presence of ballooned smooth muscle cells with clear cytoplasm. CONCLUSION: The histopathological findings of CADASIL show a characteristic arteriopathy that allow a better understanding of its pathogenesis and could contribute for its diagnosis.

Adult↗
PubMedDate not supplied

[The organization of health care for stroke. The stroke units make the difference].

INTRODUCTION: The advantages of care in stroke units (UI) are known, as are those of being in neurology wards as compared with the general medical wards, although to date there are no studies which make a comparative evaluation of the stroke team (EI) as compared with the UI with regard to benefits in care obtained by the patients. PATIENTS AND METHODS: We made a sequential analysis from the stroke register comparing three groups of patients attended during the years 1994-1996. During 1994 the patients were attended in the neurology ward by the EI. In 1995 an acute UI was set up. The criteria for inclusion or exclusion, health staff and technical resources were similar. We analysed the average stay, complications, mortality, hospital costs, functional state and destination on discharge. RESULTS: We included 1,491 patients: 435 (1994), 529 (1995) and 527 (1996). Comparing UI with EI we observed a reduced average stay (29.5%; p<0.001), fewer complications (47.8%; p<0.001), better functional state on discharge (Rankin 1 +/- 2 against 2 +/- 2; p<0.0001), increased transference to rehabilitation units (78%; p<0.001) with less long-term hospitalisation (22%; VS) and a reduction in costs ( up to 14.2%). There was no difference in mortality. CONCLUSIONS: The UI is a better system of attendance than EI for the management of strokes, since it reduces the average stay, hospital complications and health costs, as well as permitting a better functional state on discharge. Therefore treatment in the UI makes the difference in prognosis for these patients and the institutional expenses.

Acute Disease↗