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Biomedical subjects

P Bardos

Publications and source records attributed to P Bardos.

At least 145 records · Page 8Linked to original sources
PubMed1976

[Alpha-1-antitrypsin, orosomucoid, transferrin and alpha fetoprotein in the amniotic fluid, Changes in concentration in normal and pathologic pregnancies].

In this article, which is a preliminary report, the authors determined amniotic fluid levels of alpha-I-antitrypsin, orosomucoid, transferrin and alpha-fetoprotein during complicated pregnancies with gestational ages of 31 to 42 weeks. These levels were compared with those observed during normal pregnancies. The clinical value of the variations of the glycoprotein levels is discussed.

Amniotic Fluid↗
PubMed1975

[Mitral valve surgery: 10 years follow-up of 501 patients (author's transl)].

The results of mitral surgery between 1961 and 1971 are presented. Pure or predominant mitral stenosis outnumbered combined mitral valve disease and mitral incompetence by two to one. Surgical treatment comprised 291 closed mitral commissurotomies, 145 open reconstructions and 81 replacements of the mitral valve. One month mortality was 2,4% for commissurotomy, 4,8% for reconstruction, and 25% for replacement. Early mortality of the latter operation decreased to 7% since 1971. For patients with no more than slight preoperative symptoms life expectany remained unaffected for 10 years after closed commissurotomy. For patients with significant preoperative limitation or symptoms at rest 5 and 10 years life expectancy after successful surgery was 93 and 79% resp. for commissurotomy, 94 and 73% for reconstruction and 79 and 53% resp. for mitral valve replacement. In spite of a higher rate of reoperations and late deterioration of valve function the reparative operations deserve preference to the replacement of the mitral valve whenever feasible.

Adult↗
PubMed1975

[Automation of extraction in the determination of blood triglyceride].

A complete automation of the determination of triglycerides is described which replaces the manual extraction and the final determination with an autoanalyzer chain, based on the method of Royer et al. For the automation of triglyceride extraction, we have modified the sampler, by incorporating a magnetic stirrer under the sample table. The sample table has two rows of holes. The sera, which are taken from the inner row and diluted with sulphuric acid, are reacted quantitatively with the extraction reagent in the beakers of the outer row, which contain a magnetic follower. After stirring, the upper phase is quantitatively removed and the determination is started. The problem of phasing the individual steps of the analysis is thus solved.

Autoanalysis↗
PubMed1975

[Immunochemical study of glomerular basement membrane in human and experimental pathology].

After a review of the histology and the biochemical structure of the glomerular basement membrane, the authors discuss the role of its diverse antigenic components in the origin and course of several types of glomerulonephritis. In addition, they deal with the problem of biochemical modifications of glomerular basement membrane during some experimentally induced or naturally occuring pathological states.

Amino Acids↗
PubMedDate not supplied

Human Sertoli cells in vitro. Lactate, estradiol-17 beta and transferrin production.

Human Sertoli cell parameters, namely lactate, estradiol-17 beta, and transferrin production, were determined after a 24-hour incubation with either human follicle stimulating hormone (FSH) or dbcAMP in the presence or absence of testosterone plus a phosphodiesterase inhibitor (1-methyl-3-isobutylxanthine; MIX). Testicular tissues were obtained from 10 young patients (mean age, 29 years); using a 3-step enzymatic treatment, Sertoli cell enriched preparations (> 92%) were studied after 4 days as primary cultures. No significant changes in lactate, estradiol-17 beta, and transferrin outputs have been observed according to age in patients ranging in age from 16 years to 47 years. Sertoli cell production of the compounds is controlled by testosterone plus MIX; FSH (or dbcAMP) treatment only slightly improves their synthesis. It is suggested that human Sertoli cell function, as far as the parameters measured in this study are concerned, is likely regulated by cAMP-dependent and independent pathways.

Adolescent↗
PubMedDate not supplied

[Glycoproteins in maternal and fetal blood and amniotic fluid. Variations in normal and pathologic pregnancies].

In this brief note, which is a preliminary report, the authors investigated systematically the variations, during normal and complicated pregnancies, of the concentrations of alpha-1-antitrypsin, orosomucoid, transferrin and alpha feto-protein, simultaneously in maternal serum, fetal serum and amniotic fluid. There exists during normal pregnancies a difference between the concentrations of alpha-1-antitrypsin and of orosomucoid found for primigravidae and for multigravidae. The role of these glycoproteins in preventing the mother from rejecting the fetus is discussed. In addition for Rhesus isoimmunization the clinical value of the variations in the levels of transferrin is discussed.

Adult↗