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Biomedical subjects

P Barbier

Publications and source records attributed to P Barbier.

At least 109 records · Page 6Linked to original sources
PubMed1977

[Digestive origin of Campylobacter septicemias].

Whilst the animal origin fo human Campylobacteriosis is generally accepted, its epidemiology remains ill understood. Animal contact prior to a Campylobacter septicaemia is only rarely found. The frequent occurrence of episodes of diarrhoea immediately prior to the onset has led to a suspicion of a digestive portal of entry. Our aim is to provide incontrovertible proof of this hypothesis, reporting the results of systematic stool examinations for Campylobacter in the stools as well as 5 new cases of septicaemia.

Campylobacter Infections↗
PubMed1976

Importance of protease inhibition in studies on purified factor VIII (antihaemophilic factor).

According to some authors factor VIII procoagulant activity may be dissociable from carrier protein (MW approximately 2 X 10(6) by agarose gel filtration, e.g. at high ionic strength. We were able to reproduce this phenomenon. However, addition of protease inhibitor (Trasylol) prevented the appearance of low molecular weight peak of factor VIII procoagulant activity both at high ionic strength and elevated temperature (37 degrees C). We conclude from our results that procoagulant activity and carrier protein (von Willebrand factor, factor VIII antigen) are closely associated functional sites of native factor VIII macromolecule. Consequently, proteolytic degradation should be avoided in functional and structural studies on factor VIII and especially in preparing factor VIII concentrate for therapeutic use.

Antigens↗