Search PubMed⌕ Search

Biomedical subjects

P Bagros

Publications and source records attributed to P Bagros.

At least 19 recordsLinked to original sources
PubMed1999

Effects of severe protein restriction with ketoanalogues in advanced renal failure.

OBJECTIVE: To compare a severe protein restriction diet supplemented with ketoanalogues to a moderate protein restriction diet in order to limit glomerular filtration rate (GFR) decrease in an advanced renal insufficiency stage. DESIGN: Prospective randomised study conducted to compare a severe protein restriction diet (0.30 g/kg/day) supplemented with a preparation of ketoanalogues, hydroxyanalogues of aminoacids and aminoacids (Group A) to a moderate protein restriction diet (0.65 g/kg/day) (Group B). PATIENTS: 50 uremic patients included (25 in each group) with GFR is <20 mL/min/1.73m2. RESULTS: There were no statistically significant differences between the two dietary regimens for the renal survival. But uremia decreased significantly in Group A (22.7+/-5.2 to 18.5+/-6.7 mmol/L) and increased in Group B (26.8+/-9.0 to 34.9+/-9.9 mmol/L). Calcemia increased in Group A from 2.28+/-0.18 to 2.42+/-0.17 mmol/L, p<0.01 with a stable phosphoremia while calcemia decreased in Group B (2.33+/-0.18 to 2.25+/-0.17 mmol/L, p<0.05). At the end of the study, Group A was different from Group B for calcemia (2.42+/-0.17 vs. 2.25+/-0.17 mmol/L, p<0.01), phosphoremia (1.39+/-0.30 vs. 1.80+/-0.65 mmol/L, p<0.02), alkaline phosphatase (61.42+/-22.93 vs. 78.8+/-27.0, p<0.05) and parathormone plasma levels (2.71+/-1.55 vs. 5.91+/-1.41 ng/mL, p<0.001). COMMENTS: Compared to a moderate protein restriction (0.65 g/kg/day), a severe protein restriction (0.3 g/kg/day) supplemented by ketoanologues does not limit GFR decrease when GFR is below 20 mL/min/1.73m2, but improves phosphocalcic plasma parameters.

Adult↗
PubMed1994

Glucose oxidation after a peritoneal and an oral glucose load in dialyzed patients.

Glucose oxidation and thermogenesis were studied after a peritoneal (P) and an oral (O) glucose load in nine chronically uremic patients undergoing continuous ambulatory peritoneal dialysis (CAPD) for 24.4 +/- 5.8 months. The O load (50 g) given was equivalent to the amount of glucose absorbed over six hours through the peritoneum of the subjects (51.7 +/- 3.3 g). Glucose oxidation and energy expenditure were obtained using indirect calorimetry in basal state and over the six hours following the glucose load. Glucose oxidation rate was higher from 60 to 180 minutes after O than after P (P < 0.05), with peak values of 3.85 +/- 0.28 mg.kg-1.min-1 and 2.80 +/- 0.17 mg.kg-1.min-1 respectively (P < 0.05). Cumulated glucose oxidation over six hours was 53.6 +/- 0.6 versus 47.0 +/- 3.4 g after O and P respectively (NS). Glucose-induced thermogenesis was 8.7 +/- 2.9% versus 5 +/- 1.9% after O and P, respectively (NS). The route of administration of glucose induces different kinetics of the glucose oxidation rate, but a similar amount of glucose absorbed either by the peritoneum or by the gut contributes in a similar extent to glucose and energy balance.

Absorption↗
PubMed1993

Changes in parathyroid hormone during haemodialysis sessions with two different dialysis membranes: specific adsorption of intact parathyroid hormone.

In patients dialysed with two different membranes (cuprophan and high-flux polysulphone) and using three radioimmunoassays recognizing either intact molecule (iPTH), C terminal (cPTH) or median fragments (mPTH), we compared parathyroid hormone levels at the beginning of and during dialysis. At the beginning of dialysis, cPTH and mPTH levels were always increased but iPTH levels were sometimes within the normal range; during dialysis only iPTH distinctly decreased whichever membrane was used. The behaviour of iPTH cannot be explained by crossing through the membrane because its molecular weight is too high; it cannot be explained by the variation of calcium and phosphate parameters during the session because no correlation exists between the variations in plasma levels of iPTH and the variations in phosphorous and calcium levels. In vitro experimentation with radiolabelled intact iPTH was performed to confirm the specific behaviour of iPTH: these experimental data agree with our in vivo results and suggest an adhesion to the dialysis membrane. Our study shows a specific singular property of iPTH during dialysis and demonstrates the necessity of considering the time of sampling during dialysis and the moiety of parathyroid hormone being measured in patients undergoing dialysis in order to assess osteodystrophy.

Adsorption↗
PubMed1992

[Kidneys and lipids].

Nephrotic syndrome causes hypercholesterolemia. Chronic renal failure results in hypertriglyceridemia, low HDL cholesterol and, more often, apolipoprotein abnormalities. This dyslipidemia is not corrected by hemodialysis. Transplantation corrects it but leads to other kinds of lipid abnormalities. Whether the treatment of these potentially atherogenetic abnormalities is beneficial of not remains unproved. There is some evidence of lipid contribution to the constitution of glomerulosclerosis in animals but it remains hypothetical in man.

Animals↗
PubMed1990

[Evaluation of nutritional status in chronic renal insufficiency].

No nutritional criteria have been validated in uremic patients. Chronic renal failure directly alters biological nutritional criteria. Anthropometric criteria are inadequate to routine follow up, but advisable to compare groups of patients. Quantitative evaluation of nitrogen ingestion and excretion allows to control dietetic compliance. They can not be used to check long term nitrogen balance. Nutritional criteria fail to diagnose mild undernutrition in uremic patients but they help to detect patients at risk to develop undernutrition when ascribed to low protein diets. Food inquiries, conducted by well trained dietitians are quite advisable, and helpful to the patients.

Amino Acids↗
PubMed1990

[The contribution of color-coded Doppler in early vascular complications of kidney transplantation].

Ultrasound techniques and radionuclide studies are very often used to assess vascularization of renal transplants. Although, in acute tubular necrosis or acute rejection, it is difficult to choose between these two techniques, in 3 recent cases of renal artery thrombosis, we conclude that color coded Doppler is preferable to nuclear medicine or duplex system to diagnose this form of thrombosis.

Adult↗
PubMed1989

[Renal leiomyoma. Apropos of a case].

Leiomyoma of the kidney is a rare tumor, for which little investigational imaging data is available, and which is poorly characterized by histological methods. We are here concerned with one case that benefitted from an extensive radiological workup, and we provide a comparison with other cases mentioned in the literature.

Diagnostic Imaging↗
PubMed1982

[Vaccination against hepatitis B in a hemodialysis unit. A 4-year follow up (author's transl)].

From February 1976 to January 1980, 123 staff members and 84 hemodialysis patients were immunized against hepatitis B in an adult hemodialysis unit. The vaccine was prepared by purification of HBs Ag from human sera and was formalin inactivated. Vaccines were tested for seric markers of HB virus (HBs Ag, anti-HBs, anti-HBc) and serum transaminases (ALT, AST) before immunization and every month during the follow up. Tests for markers of auto-immunity were performed. The vaccinees were followed from 4 to 48 months. No evidence of long-lasting reactions to the HB vaccine or auto-immunity was observed. 91% of the staff members sero-converted for anti-HBs; none of them showed clinical, biologic or serologic signs of active HB infection; 62% of the hemodialysis patients sero-converted for anti-HBs; none of them became HBs Ag chronic carrier. These results were obtained despite the fact that the prevalence of HBs Ag chronic carriers was 32.7% when the study began. Active immunization proved to be a safer and efficient method to prevent HB infection in a hemodialysis unit.

Autoantibodies↗
PubMed1980

[Bartter's syndrome: seven cases in siblings. Hypothesis of mild forms (author's transl)].

Three children with a Bartter's syndrome have been investigated: all of them had growth retardation, hypokalemia (less than 3 mmol/l), raised plasma renin activity and urinary prostaglandins (PGE2 and PGF2 alpha) and a decreased sensibility for angiotensin. In the siblings two children had also growth retardation with mild biological signs of Bartter's syndrome, and two children had normal growth slight hypokalemia raised RPA and urinary PH, and normal sensibility for angiotensin. These data suggest mild forms of this syndrome which could be the Bartter's syndrome diagnosed in adults after laxatives or diuretics absorption. Besides these data stated a negative correlation (p less than 0,01) between plasma K+ and RPA, negative correlation (p less than 0,01) between plasma K+ and urinary PGE2 and a positive correlation (p less than 0,01) between RPA and urinary PGE2. From these observations physiopathology of Bartter's syndrome is discussed.

Adolescent↗